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Effect on face and body by BNLS neo of lipolytic injection and risk downtime




Seong Eun Yoon
Dr. Seong Eun Yoon


Dermatologist International Academic Director, Korea Cosmetic Surgery Association Director, Korean Society of Obesity and Beauty Treatment Director, Korean Society of Nanomedicine Director, Korean Society of Beauty and Welfare Director, Korean Hyaluronic Acid Society

BNLS neo is a type of drug used in lipolytic injections . It has the effect of causing necrosis of fat cells by destroying the cell membrane of fat cells and releasing the neutral fat stored inside, making it impossible to maintain the functions and activities of cells.

Necrotic fat cells by BNLS neo are naturally excreted outside the body, so subcutaneous fat, which is a collection of multiple fat cells, can be expected to decrease . By reducing subcutaneous fat, the face line is adjusted, and cellulite on the hip line and thighs is improved.

However, BNLS neo has an upper limit to the amount that can be injected in one treatment. Therefore , in cases where there is a large amount of fat to be reduced or there are multiple areas where treatment is desired, it is important to know in advance the number of treatments required and the approximate cost by knowing the approximate amount of injection that differs for each area. is.

In addition, there are treatments that can be expected to have a synergistic effect on facial thinning and partial slimming by receiving them together, so if you want to increase the effect, compare and consider each treatment.

Dr. Yoon Seong-eun, the leader of BNLSneo for lipolytic injections

Effects of BNLS neo on facial and body fat

Fat dissolving injection is a slimming treatment that directly injects a drug that decomposes subcutaneous fat cells in the face and body and leads to reduction, and "BNLS neo" is being developed by a medical institution called Brand New Clinic in Korea It is a lipolytic injection drug that I am involved in.

Illustration of the action of BNLS neo on adipocytes

BNLS neo has the effect of dissolving the cell membrane covering the fat cells, making holes and destroying them. Adipocytes are cells that play a role in storing neutral fat generated in the body, and when the cell membrane is destroyed by BNLS neo, the stored neutral fat is released and shrinks.

Some adipocytes regenerate their cell membranes quickly and survive, but most adipocytes are unable to maintain cell function and activity because their cell membranes do not close immediately and die. Necrotic fat cells are preyed on and digested by macrophages, which are amoeba-like white blood cells, and are excreted from the body along with waste products in urine and feces through blood vessels and lymphatic vessels.

In addition, since BNLS neo has a vasodilating effect, it is said to increase blood flow and promote metabolism of waste products and decomposed fat accumulated in blood vessels. Since BNLS neo can be expected to reduce fat mass by decomposing fat cells at the site of intradermal injection and promoting metabolism, medical institutions that are labeled as ``small face injection'' or ``partial slimming injection''. There is also

BNLS neo treatment is suitable for those who have the following problems caused by increased subcutaneous fat.

  • Those who are concerned about fat on the forehead, upper eyelids, nose, and cheeks
  • Those who want to improve the sagging face line and double chin
  • Those who are concerned about fat in the arms, armpits, back, thighs, and calves
  • Those who want to slim down their waistline and hipline
  • Those who want to improve cellulite
  • Those who are resistant to surgical procedures such as liposuction with long downtime

Active ingredients and mechanism of action of BNLS neo

It is a drug whose main ingredients are plant-derived extracts extracted from seaweed and walnuts, and purines and amino acids that are originally produced in the human body. It contains the following nine active ingredients, each of which acts on subcutaneous fat and promotes the metabolism of decomposed fat.

adenosine triphosphate

Adenosine, which is a substance that originally exists in the human body and is formed by binding adenine, one of the purines, and ribose, a type of sugar, to adenosine, which is formed by binding three phosphate molecules, is called adenosine triphosphate. .

Adenosine triphosphate relaxes the smooth muscle of the muscle that regulates the thickness of blood vessels, widens the blood vessels and increases blood flow, and promotes the formation of new blood vessels.

Adenosine triphosphate disodium

Disodium adenosine triphosphate is the compound formed by binding two sodium molecules to adenosine triphosphate.

It is a component that serves as an energy source for cell activity, and has the effect of enhancing cell function and muscle activity. It is also used as an ingredient in medicines that improve heart failure and eye strain.

horse chestnut seed extract

This extract is made from the seeds of the horse chestnut (Western horse chestnut), which is one of the deciduous trees.

Escin, a bitter component that is said to reduce redness of the skin by suppressing skin inflammation, is said to have the effect of relieving swelling and providing elasticity to capillaries.


Tyrosine, one of the amino acids, synthesizes the neurotransmitter catecholamines by reacting with intracellular enzymes. Catecholamine has the effect of stimulating and activating the protein necessary for intracellular information transmission called "β3 adrenergic receptor" present in the brain and fat cells.

Activated β3-adrenergic receptors bind to noradrenaline, a hormone secreted by the adrenal glands, to break down neutral fat accumulated in adipocytes into free fatty acids that are used for energy consumption in the body during exercise and basal metabolism. and promotes its release into the blood.

deoxycholic acid

Deoxycholic acid, one of the bile acids produced in the human body, is an ingredient recognized by the FDA (US Food and Drug Administration) for its fat-dissolving effect on double chins .

Reference Kybella (deoxycholic acid) injection: FDA

By dissolving and destroying the cell membrane covering the fat cells, it works to release the neutral fat stored in the cells. Adipocytes whose cell membranes have not been regenerated cannot maintain their functions and activities as cells and die.

fucus extract

An extract of brown algae called fucus, which is a kind of seaweed, and contains minerals such as zinc and iodine, as well as collagen and amino acids. Zinc is a component that is necessary when protein synthesis is performed in the body and new cells are created.

Iodine is a mineral necessary for the production of the hormones "thyroxine" and "triiodothyronine" secreted into the blood by the thyroid gland, and these two hormones are called thyroid hormones. Thyroid hormone acts on every cell in the body and is said to have the function of promoting metabolism such as sugar and lipid metabolism and protein synthesis.

persian walnuts

A type of walnut native to eastern Europe, it contains α-linolenic acid, an essential fatty acid that humans cannot synthesize in the body. Alpha-linolenic acid is said to have the effect of synthesizing DHA and EPA, essential fatty acids that reduce LDL (bad) cholesterol in the blood, which causes arteriosclerosis.

Persian walnuts also contain vitamin E and arginine.
Vitamin E has an antioxidant effect, and it is said that it has the effect of suppressing the formation of lipid peroxide that causes arteriosclerosis and aging of blood vessels. Since arginine, one of the amino acids, has a vasodilating effect, it can be expected to have the effect of promoting blood circulation and increasing blood flow.

Methylsilanol mannuronate

Methylsilanol mannuronic acid is a component consisting of alginic acid (mannuronic acid) contained in brown algae such as kelp and wakame and methylsilanol, a compound containing silicon, which is a type of mineral.

It mainly breaks down neutral fats and emulsifies cholesterol (lipids) in the blood, making it easier to be metabolized outside the body. can be expected.

methyl propanediol

Methylpropanediol, a type of fermented alcohol made from starch, is said to have a moisturizing effect that prevents the moisture content of the stratum corneum, the top layer of the skin, from decreasing, and an effect that increases the permeability of active ingredients.

It also has an antibacterial effect that prevents the growth of bacteria and an antiseptic effect that suppresses spoilage due to the growth of microorganisms, so it tends to be used as a stabilizer in skin care products such as facial cleansers and cosmetics.

Decomposed fat cells cannot regenerate

BNLS neo has the effect of destroying the cell membrane of adipocytes and releasing the internal neutral fat, making it impossible to maintain cell functions and activities, thereby causing necrosis of adipocytes.

It also has the effect of promoting the excretion of necrotic fat cells, so it can be expected to have the effect of reducing the number of fat cells present at the site of intradermal injection. Fat cells that are decomposed and discharged outside the body do not regenerate, so they do not store neutral fat and become enlarged.

Adipocytes exist widely under the skin of the whole body, and although there are individual differences, the total number of adipocytes is said to be 35 to 40 billion in adults. The number of fat cells is most likely to increase between the ages of 10 and 18, and it is difficult for the number to increase or decrease significantly after reaching adulthood. The size of adipocytes that store neutral fat is generally considered to be about 0.08 mm in diameter, but those that continue to accumulate neutral fat and become enlarged may expand to about 0.14 mm in diameter.

BNLS neo has less rebound worries

Suppression image of rebound due to reduction of fat cells

The symptoms of excess subcutaneous fat on the face and body are not caused by an increase in the number of fat cells, but by fat cells accumulating neutral fat and becoming enlarged. Fats and sugars ingested in meals are absorbed in the intestines and used for energy consumed by physiological functions such as heartbeat and breathing through blood vessels, but surplus energy is converted to neutral fat in the liver and adipocytes. is stored in

Neutral fat stored in fat cells is decomposed by enzymes and converted into free fatty acids when the energy required to perform physiological functions is insufficient due to intense exercise or hunger, and is supplied to the whole body through blood vessels to restore physiological functions. used as the energy consumed by Therefore, by dieting such as exercise and dietary restrictions, neutral fat can be decomposed and the size of subcutaneous fat can be temporarily reduced, but the fat cells themselves will only become smaller and the number will not decrease.

Excessive intake of lipids and sugars in the diet causes fat cells to accumulate again and become enlarged, so while a general diet may rebound, BNLS neo destroys fat cells and removes them from the body. It can be said that there is little concern about rebound because it has the effect of reducing the number of fat cells by promoting the excretion of fat cells .

BNLS neo can aim for small face and body parts

The reason why subcutaneous fat on the face such as cheeks, eyes, and nose is difficult to remove is said to be related to the weakening of facial muscles. There are more than 20 types of facial muscles that move parts of the face, but it is said that 20% to 30% of all facial muscles are used on a daily basis.

When facial muscles weaken, the basal metabolic rate of the face and around the face decreases, blood flow stagnate, and fat on the face and waste products in the blood become difficult to metabolize. However, if you train the facial muscles too much, the masseter muscle near the cheekbone may develop and the gills may look stretched.
BNLS neo is a drug that can be injected into the face, so you can aim to slim your face by improving problems such as sagging face lines, double chins, and dumpling noses .

In addition, when aiming to reduce subcutaneous fat on the body through exercise-based dieting, by performing aerobic exercise such as jogging and swimming, neutral fat stored in fat cells is converted into free fatty acids and consumed as energy. However, since aerobic exercise is a full-body exercise, it is difficult to achieve “partial slimming,” which aims to reduce fat in limited areas while maintaining fat that you want to keep, such as the chest and hips.

On the other hand, if you continue to diet due to excessive dietary restrictions, your body's basal metabolic rate will decrease. The basal metabolic rate is the amount of energy consumed by the minimum necessary physiological functions to sustain life, such as heartbeat and respiration.
When the basal metabolic rate drops, the body temperature drops and the blood vessels shrink, which makes it easier for cholesterol in the blood to accumulate on the walls of the blood vessels, increasing the risk of arteriosclerosis.

BNLS neo has the effect of reducing fat cells at the injection site without lowering the basal metabolic rate, so you can aim for partial weight loss without going on a diet that puts a strain on the body .

BNLS neo leads to improvement of cellulite

The unevenness that appears on the skin surface, such as around the waist, thighs, and hip lines, is called cellulite, and cellulite is said to appear more often in women than in men.

Cellulite is a collection of fat cells (subcutaneous fat) that have accumulated neutral fat and become enlarged, creating unevenness by lifting the skin, and the structure is said to be the same as general subcutaneous fat. Therefore, by intradermally injecting BNLS neo into areas where cellulite is a concern, it can be expected to have the effect of decomposing enlarged fat cells and adjusting the unevenness of the skin .

BNLS neo pain, injection amount for each site such as nose and cheek

BNLS neo is injected intradermally using a painless needle

BNLS neo injection method illustration using a cannula

BNLS neo uses an injection needle called an ultra-fine injection needle with a sharp tip, or a cannula (blunt needle) with a round needle tip and a needle hole on the side from which the drug comes out. Inject intradermally into the area of concern . Depending on the medical institution, if desired, anesthetic cream or laughing gas anesthesia may be used before injecting BNLS neo.

Needles with pointed tips that are commonly used for blood sampling and local anesthesia are called sharp needles. The thinner the sharp needle, the less pain there is during injection and the scar is less noticeable, so most medical institutions use ultra-fine needles. is.

The blunt needle cannula is also a thin needle, so there is little pain during the procedure, and the tip of the needle is rounded, so it does not damage small blood vessels, so it is said that the risk of internal bleeding and redness is low. In addition, since it is flexible and bendable, and the needle hole from which the drug comes out is on the side, it is easy for the practitioner to control the direction of drug injection by rotating the needle under the skin. The type and thickness of injection needles handled by medical institutions differ, so if you are concerned about pain, please check with the medical institution where you are considering undergoing the procedure.

Areas where BNLS neo is suitable and indication of injection amount

BNLS vial BNLS neo differs depending on the medical institution, and may not be operated around the eyes or the nostrils. When considering treatment, please check the website etc. for the parts that are supported by each medical institution.

Also, the maximum amount of BNLS neo that can be injected per treatment is 50cc . For the face, the upper limit per injection is 20cc, and when performing treatments on multiple parts of the face and body, the total upper limit that can be injected per injection is within 50cc.

If you inject a dose that greatly exceeds the maximum per dose, there is a risk of swelling and inflammation . Therefore, if the amount of subcutaneous fat that you want to reduce is large and the maximum amount that can be injected per treatment is exceeded, the treatment is divided into multiple treatments.

Applicable part Estimated amount of injection per injection
Cheeks/upper eyelids 1cc to 2cc each
Nose, nostrils, cheekbones 1cc to 4cc each
Corners of the mouth/Face line 1cc to 5cc each
Front and back armpits, thighs, lower legs, ankles 2cc to 5cc each
Upper Abdomen, Lower Abdomen, Side Abdomen, Back 5cc to 20cc each
Upper buttocks/lower buttocks 10cc to 30cc each

Course after injection of BNLS neo and duration of effect

Effect on face and body by BNLS neo of lipolytic injection and risk downtime

Effects begin to appear 3 to 5 days after injection

BNLS neo is an intradermal injection of a liquid drug, so the drug causes swelling at the treatment site immediately after the treatment, but it is gradually absorbed into the body over half a day to a day.

There is no immediate effect that the effect appears immediately after the treatment, but many people who have undergone the treatment feel a reduction in subcutaneous fat about 5 days after the injection. In early cases, the effect may begin to appear as early as 3 days after the injection, but changes in the progress may vary from person to person depending on the original fat mass and metabolic rate.

1 day to 3 days Redness due to inflammation, swelling, and internal bleeding may occur, but in most cases it subsides within 2 to 3 days.
3 to 5 days A guideline that many people who have undergone the treatment can feel the effect
5 to 7 days A guideline that the decomposed fat is metabolized and the effect of BNLS neo is felt most

Duration of effect and benefits of receiving multiple treatments

Necrotic and expelled fat cells do not regenerate, so the effect of making it difficult for subcutaneous fat to increase in the treated area lasts semi-permanently. However, it does not necrotic all the fat cells present at the injection site .

Even if you feel fat loss in your face and body, if you continue with irregular lifestyle habits such as overeating and lack of exercise, the remaining fat cells that have not died may become enlarged again. In order to maintain the effect, it is important to keep a healthy diet and moderate exercise in mind.

In addition, subcutaneous fat can be expected to be reduced with one treatment, but it is said that you can feel the effect more by receiving it 2 to 5 times . If you have a large amount of subcutaneous fat that you want to reduce, divide the treatment into multiple injections and aim for gradual slimming.

When performing multiple treatments, it is recommended to receive them at intervals of 1 to 2 weeks, and it is said that repeated treatments will not be affected even if there is an interval of 2 weeks or more.

Comparison of BNLS neo with other drugs/treatments

Comparison with "1st generation BNLS" and "BNLS Version2"

BNLS neo is the third generation drug in the series developed after "first BNLS" and "BNLS Version2". Production of the first generation BNLS ended in 2016 and BNLS Version 2 ended in 2017.

active ingredient First generation BNLS BNLS Version2 BNLS neo
adenosine triphosphate
Adenosine triphosphate disodium
horse chestnut seed extract
deoxycholic acid - -
fucus extract
persian walnuts
Methylsilanol mannuronate -
methyl propanediol -

Differences between BNLS neo and other lipolytic injection drugs

There are many drugs for lipolytic injections other than BNLS neo, but they can be roughly divided based on the main ingredients contained in "drugs mainly composed of plant extracts" and "drugs mainly composed of deoxycholic acid and phosphatidylcholine." There are two types of "component drugs", and BNLS neo is classified as the former. The latter drug can be said to have a high effect on fat cells, but downtime may take up to two weeks.

Drug name of main lipolytic injection Drug characteristics
Caibera A drug containing a high concentration of deoxycholic acid has a high effect of decomposing fat, but strong inflammation and swelling may occur at the injection site.
Fat X It is a drug that is said to have a high effect of breaking down fat and promoting metabolism, and contains high concentrations of deoxycholic acid, so inflammation and swelling are likely to occur.
MITI A drug that contains deoxycholic acid as the main ingredient and also contains ingredients that have the effect of suppressing skin inflammation, and is said to have short downtime such as inflammation and swelling.
LINE Fit Deoxycholic acid is the main component of the drug, and in addition to decomposing fat and promoting excretion, it is said to have the effect of reducing cholesterol in the blood.
lipobean It is a drug approved by KFDA (Korea Food and Drug Administration) while it is said that the downtime of inflammation and swelling is long due to the main ingredients of deoxycholic acid and phosphatidylcholine.
contour injection It contains plant extracts as the main ingredient, and while its action is mild compared to general drugs, it is said that there are almost no downtime symptoms such as inflammation and swelling.

Those who are suitable for injection treatment other than lipolytic injection

  • Those who want to improve gill tension due to masseter muscle development: botulinum injection

Botulinum injection is a treatment that injects ingredients that remove toxins that affect the human body from Clostridium botulinum.

It is said that it has the effect of relaxing the muscles and suppressing the movement of the muscles, and if the gills look stretched due to excessive development of the masseter muscles, botulinum injection suppresses the contraction of the masseter muscles and straightens the gill lines. You can expect the effect of

  • Those who want to improve age-related smile lines and horizontal wrinkles on the forehead: Elance

Collagen, which plays a role in maintaining the firmness and elasticity of the skin, when it decreases, the firmness and elasticity of the skin are lost, making it easier for wrinkles and sagging to occur, which appear as nasolabial folds and horizontal wrinkles on the forehead.

By injecting elanse, a drug that promotes the production of collagen, it is expected that collagen will be increased, the firmness and elasticity of the skin will be restored, and the effect of improving smile lines and horizontal wrinkles on the forehead can be expected.

  • Those who want to improve wrinkles and contour: Hyaluronic acid injection

It is a procedure that injects hyaluronic acid, a substance that originally exists in the human body and has excellent viscoelasticity.

By supplementing the volume of the skin in the injected area, it can be expected to have the effect of making deep wrinkles such as small wrinkles around the eyes and smile lines inconspicuous. It is also used as a contouring treatment that aims for the ideal face line by injecting it into the nose and chin.

  • Those who want to undergo treatment with a dermal filler other than hyaluronic acid: Argenes®

Argenes® is an injection agent whose main component is a fibrous substance (polysaccharide) in which multiple sugars are linked together called agarose, and it is a dermal filler with different properties from hyaluronic acid. It has the effect of supplementing the volume of the injected skin, and can be expected to have effects such as contouring and improving nose prominence and wrinkles.

Difference between BNLS neo and liposuction

Liposuction is an operation in which an incision of a few millimeters is made on the surface of the skin and the fat cells are removed by sucking them with a thin tube into the layer where there is subcutaneous fat . If the treatment is extensive and a large amount of subcutaneous fat is removed at once, downtime will continue for a long time, which will put a heavy burden on the body.

On the other hand, BNLS neo has a short downtime and also has the effect of reducing the number of fat cells. However, if there is a large amount of subcutaneous fat that you want to remove, you will need to visit the hospital several times and divide the treatment into multiple treatments, so the total cost may be high.

Difference between BNLS neo and buccal fat removal

The fat on the inside of the cheek is called buccal fat, and buccal fat removal is a surgical procedure that surgically removes this fat by incising the mucous membrane of the mouth by a few millimeters . Buccal fat hangs down with age, causing sagging cheeks and deep nasolabial folds, resulting in a “bulldog face.” No scars will appear on the surface of the skin, but downtime for inflammation and swelling will take about a week.

BNLS neo can also be expected to improve the bulldog face by reducing subcutaneous fat on the cheeks, but unlike buccal fat removal, skin incision is not performed.

Difference between BNLS neo and HIFU treatment

HIFU, which is energy focused by ultrasonic waves, has the effect of generating heat of 60 ° C or more only in the "SMAS layer" of the fascia under the subcutaneous fat and contracting it . The SMAS layer is a fascia that supports the skin of the face, but when it relaxes with age, it causes sagging of the skin, so treatment that contracts the SMAS layer is effective in improving sagging.

You can expect a lift-up effect by shrinking the SMAS layer with heat, and the main machines include Ulthera, Doublo Gold, Ultraformer III, and Sonoqueen.

Sagging facial skin may be improved by reducing subcutaneous fat due to the action of BNLS neo, but sagging skin caused by loosening of the SMAS layer cannot be improved.

Difference between BNLS neo and RF (radio wave) treatment

RF, also known as radio waves, is a high-frequency wave that, when irradiated on the skin, becomes minute vibrations that are transmitted through the body, causing the molecules of water in the body to rub against each other to generate heat . When the heat generated warms the deep part of the body, enzymes that work to break down triglycerides and convert them to free fatty acids are activated.

RF treatment can be expected to have a slimming effect by activating enzymes, but it does not have an immediate effect. BNLS neo is said to be effective in 3 to 5 days after intradermal injection, but in order to feel the effect of RF treatment, it is ideal to receive a total of 5 treatments at intervals of 1 to 2 weeks. will be

BNLS neo risks, side effects and downtime

Two risks of injecting BNLS neo

Failure to finish due to excessive reduction of subcutaneous fat

It is said that it is better to leave some subcutaneous fat on the upper eyelids and cheeks to maintain the balance of the entire face. Excessive reduction of subcutaneous fat in the upper eyelids and cheeks can create a left-right difference around the eyes and make the cheeks hollow and give an aged impression .

In order to prevent failure due to excessive reduction of subcutaneous fat, refrain from receiving treatment based only on your ideal design, and decide the injection site and amount while receiving advice from the doctor.

Redness appears on the surface of the skin due to internal bleeding due to intradermal injection

When injecting BNLS neo, if the subcutaneous fine blood vessels are damaged by the injection needle, internal bleeding may occur and redness may appear on the skin surface .

Even if small subcutaneous blood vessels are damaged and bleeds, blood clots are formed by countless platelets flowing through the blood, and the bleeding is immediately stopped.

BNLS neo side effects and downtime

Inflammation occurs in cells, and side effects such as swelling, redness, pain, heat, and tightness may appear during downtime. In rare cases, side effects such as numbness, itching, and hives may occur at the treatment site.

However, since BNLS neo is mainly composed of plant extracts, the downtime is shorter than that of general fat-dissolving injection drugs, and the following side effects are said to subside in 2 to 3 days. increase.

      • Symptoms that may appear as side effects: swelling, redness, pain, heat sensation, tightness
      • Rare side effects: numbness, itching, hives

Precautions when receiving BNLS neo treatment

BNLS neo is an unapproved drug in Japan

BNLS neo is an unapproved drug by the Ministry of Health, Labor and Welfare.
Acquisition route of pharmaceuticals: The acquisition route is personal import from the manufacturer by the doctor of each medical institution.
About medicines to be careful about when importing for personal use (Ministry of Health, Labor and Welfare page)
Approval in Japan: There are no drugs that have the same ingredients and actions as BNLS neo and have been approved in Japan.
Information on safety in other countries: Deoxycholic acid, the active ingredient of BNLS neo, has obtained the following approval from the US FDA.
Date of approval Approved Indications
2015.04.29 Moderate to severe submandibular fat loss in adults
Side effects in this approval: Swelling, bruising, pain, redness at the injection site, facial muscle weakness, jaw nerve damage as rare serious side effects

Those who cannot receive BNLS neo

You can take BNLS neo during menstruation or while taking contraceptives (the pill), but those who fall under the following items cannot take BNLS neo.

      • Those with thyroid disease, walnut or seaweed allergy
      • Those who are pregnant or breastfeeding
      • Those who are undergoing anticancer drug treatment
      • Those who have unhealed trauma or inflammation on or around the treatment site
      • Those with immunodeficiency diseases, those with autoimmune diseases
      • Those with microangiopathy or vascular insufficiency
      • Those who have consumed alcohol on the day of the procedure
      • Others who have been judged unsuitable by the medical institution receiving the treatment

Also, people under the age of 18 may not be able to receive the treatment. Since the number of fat cells generally tends to increase during the growth process of the body between the ages of 10 and 18, even if there is a temporary fat reduction effect, the number of new fat cells will continue to increase in the future and will rebound. Due to the possibility, some medical institutions do not perform treatments for people under the age of 18 .

BNLS neo treatment flow and price

Flow of BNLS neo treatment

(1) Examination/Counseling

After completing the questionnaire, you will receive a doctor's examination and counseling. Tell the doctor the area you want to be treated and the image of the finish you want to aim for, and decide the injection site and amount.

You will also receive explanations about the type of needles to be used, the risks of the treatment, side effects, downtime, etc. If you have any questions or concerns, please ask the doctor at this time.

(2) Face washing/anesthesia

If the part you want to be treated is the face and you were wearing make-up on the day of the treatment, cleanse and wash your face to remove the make-up. After disinfecting the treatment site and marking it, cooling is performed to relieve pain, and if anesthesia is used, anesthetic cream is applied or local anesthesia is used.

(3) Treatment

BNLS neo is injected intradermally using a very fine needle or cannula. Even without anesthesia, needle insertion is less painful. The time required for the treatment varies depending on the site and injection amount, but it is a guideline of 10 to 30 minutes.

(4) Cooling and termination

Cool the treated area for 5 to 10 minutes to reduce swelling. When injecting into the face, makeup can be applied from the next day and should be avoided on the day, so if you are concerned, please bring a mask or something that can hide your face on the day of the treatment.

Precautions after receiving BNLS neo treatment

      • On the day of treatment, do not touch the treatment area as much as possible

If bacteria invade through the needle marks caused by the procedure, pus or swelling may occur. In order to prevent the invasion of bacteria, please spend as little time as possible touching the treatment site on the day of treatment.

      • Refrain from drinking alcohol and bathing on the day of treatment

Alcohol has the effect of dilating blood vessels and increasing blood flow, which may spread internal bleeding and worsen swelling, so please refrain from drinking alcohol on the day of surgery. Also, in order to prevent the spread of internal bleeding due to a rise in body temperature, please avoid bathing on the day of the treatment and only take a shower. The sauna can be used from the 4th day after the treatment.

      • Refrain from massaging the treatment area during periods of swelling and pain

During periods of swelling and pain, massage should be avoided as it may prolong swelling and increase pain.
However, after the swelling and pain subside, massaging the site where BNLS neo was injected makes it easier for the drug to spread intradermally and act on fat cells.

Price of BNLS neo

Since BNLS neo treatment is a free medical treatment not covered by insurance, all costs will be borne by the patient. The price varies depending on the medical institution, but the market price is about 6,000 yen to 17,000 yen per cc.

Also, if a certain amount (10cc as a guideline) or more of BNLS neo is injected per treatment, some medical institutions will charge less per 1cc. If you receive treatment at a medical institution that uses anesthesia as an option, anesthesia fee will be charged separately if you request anesthesia.

How to increase the BNLS neo effect and how to choose a medical institution

Perform aerobic exercise for 3 days from the day of treatment

When you perform aerobic exercise such as jogging or swimming, neutral fat stored in fat cells is consumed as energy. In addition, since aerobic exercise improves the basal metabolic rate, the action of BNLS neo makes it easier to excrete neutral fat released from adipocytes to the outside of the body.

Therefore, it is recommended to do aerobic exercise for at least 1 hour per day for 3 days from the day of treatment.

Receive treatments that can be expected to have a synergistic effect by using them together

botulinum injection

By receiving a botulinum injection that relaxes the muscles and improves the condition in which the gills appear stretched due to the development of the masseter muscle, the gills line can be adjusted and the face line can be improved.


The heat action of HIFU shrinks the SMAS layer underneath the subcutaneous fat, which can be expected to have a lift-up effect.

thread lift

Thread lift is a procedure in which a thread is inserted under the skin where sagging is a concern, and the skin tissue is pulled up and fixed with the thread. You can expect to improve the slackness of the face line by receiving it together.

fat impact

Fat impact is one of the slimming treatments that irradiate shock waves to shrink fat cells, and it is a treatment that applies the technology that was originally used to treat urinary calculi in areas other than the face.
By taking it together, it will act on the subcutaneous fat on the body and aim for more effective partial slimming.

cool tech

Cooltech is a slimming treatment that sucks subcutaneous fat from the surface of the skin, cools it, and freezes the fat cells to necrosis. Water freezes at 0°C, whereas fat cells freeze at 4°C. Utilizing this property, only the fat cells freeze, so the surrounding tissues are not damaged.

By receiving it together, the effect of reducing fat cells is further improved, and you can aim for a clean body line.

How to choose a medical institution to receive BNLS neo

By injecting BNLS neo into areas where you are concerned about subcutaneous fat on the face or body, you can expect a small face effect and partial slimming effect. However, when a doctor with little knowledge and experience of slimming treatment performs the treatment , the cheeks look sunken due to the excessive reduction of subcutaneous fat, and the fat on the thighs, upper arms, and waist area is different from left to right. may lead to

In order to prevent failure, it is necessary to have a doctor who can judge the subcutaneous fat that should be left to some extent and the subcutaneous fat that can be removed without any problems.

Therefore, doctors who have a wealth of experience in slimming treatments such as fat dissolving injections and liposuction, and doctors who are familiar with the anatomy of the skin and can accurately determine the depth of subcutaneous fat that varies depending on the part of the face and body. If you are a medical institution that is enrolled , you can entrust BNLS neo treatment with peace of mind.

In addition, there are cosmetic dermatologists and beauty clinics that advertise campaigns such as recruiting free monitors for lipolytic injection treatments such as BNLS neo, but the National Consumer Affairs Center of Japan warns against advertisements for such campaigns. I am doing it.

According to the materials published by the National Consumer Affairs Center of Japan, a patient who came to the hospital for counseling after finding an advertisement for recruiting free monitors for lipolytic injections was told by a counselor that ``free is only for the abdomen and other parts are charged.'' , Furthermore, there have been reports of consultation cases in which the contract for the treatment was rushed by being told in quick succession, ``You should get the treatment sooner.

Since there are cases of troubles like the above, the National Consumer Affairs Center of Japan does not rely only on advertising information such as campaigns, but collects information such as treatment details, treatment fees and risks, and compares and considers multiple beauty clinics. This is just an example of advice.

References Aesthetic medical services rushing contracts for expensive treatments: National Consumer Affairs Center of Japan


Dr. Yoon Song Eun, who supervised the article, taught me about BNLS neo.

What are the features of BNLS neo?
Dr. Yoon
It is a formulation consisting of several ingredients that can be expected to dissolve fat, including FDA-approved deoxycholic acid. Since the plant-extracted ingredients are the main ingredients and swelling and pain are less likely to occur after injection, it is a good option, especially if you are aiming to slim your face.
How painful is the procedure?
Dr. Yoon
Since it is an injection procedure, you will feel a sharp pain, but if you use anesthesia, you will hardly feel any pain.
Are there any precautions after receiving the treatment?
Dr. Yoon
The scar from the injection needle is almost invisible, but to prevent bacteria from entering, please do not touch the treatment site much on the day of the treatment. Also, please refrain from excessive drinking and bathing on the day as it may cause swelling and internal bleeding.
Please tell me the treatment fee at BRAND NEW CLINIC.
Dr. Yoon
The treatment fee varies depending on the amount of injection and the area, but as a guideline, it is about 165,000 yen including tax (16,500 yen per cc) for one facial treatment.
Please give a message to those who are wondering whether to take BNLS neo.
Dr. Yoon
BNLS Neo is a fat-dissolving agent that has greatly improved pain and swelling, which were the drawbacks of conventional fat-dissolving agents. It is a treatment that many patients can receive with peace of mind, so I would like patients who have been hesitant about fat dissolving treatment to try it.
Thank you Yoon Song Eun!

Introduction of supervising doctor

Dr. Yoon Song Eun, who is the representative director of BRAND NEW CLINIC in Korea and has worked on the development of BNLS neo, a lipolytic injection. In addition to giving lectures at numerous symposiums, including the Korean Society of Aesthetics, he held study sessions and seminars on BNLS neo treatment techniques at medical institutions around the world. In 2020, he will also be involved in the development of the latest model of the BNLS series, “BNLS Ultimate”.