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Massage peel PRX-T33, which promotes collagen production, has the effect of improving the lack of...




Seiko Soyama
Dr. Seiko Soyama

Seiko Medical Beauty Clinic Kagoshima-in

Japan Dermatological Association member Japanese Society for Medical Hair Removal Member of Japan Society of Aesthetic Dermatology Japan Medical Epilation Association


Medical institution with Dr. Seiko Soyama

Seiko Medical Beauty Clinic Seiko Medical Beauty Clinic Kagoshima
Seiko Medical Beauty Clinic Fukuoka
Contact information for Kagoshima Temple: 0120-172-117
Contact information for Fukuoka-in: 0120-126-265

PRX-T33 is also called “massage peel” or “collagen peel” because it penetrates the ingredients and promotes collagen production by applying it to the skin and massaging it .

PRX-T33 is one of the treatments that is easy to receive even for those who are new to cosmetic medicine because it is easy to understand the effect of tightening the skin immediately after treatment and the treatment of penetrating the ingredients with a massage. In addition, for those who have already received aesthetic medicine, the effect may be enhanced by using PRX-T33 in combination with the current treatment.

By knowing the effects of PRX-T33, the frequency and number of treatments, and the treatments that are more effective when used together, you can aim to improve skin quality efficiently.

Massage peel PRX-T33, which promotes collagen production, has the effect of improving the lack of firmness PRX-T33 (massage peel) that promotes collagen production and brings firmness

PRX-T33 was developed by Dr.Rossana Castellana in Italy as a peeling agent for medical institutions after more than 10 years of clinical research.

Chemical peeling is a treatment that removes old keratin and waste products by applying a drug to the skin and exfoliating the skin with a frosting effect. Although PRX-T33 is a type of peeling, it does not cause frosting and promotes collagen production. By applying PRX-T33 to the skin and massaging it to penetrate it, old collagen is replaced with new collagen, and the skin becomes firmer, so fine wrinkles, open pores, acne, and acne scars are improved when applied to the face. , If it is a body treatment, you can expect to improve stretch marks .

Difference from chemical peeling that acts on the epidermis

Originally, the word peeling means "peeling", so the action of chemical peeling is to remove old keratin on the surface of the skin . It is a treatment that aims to improve dullness, rough skin, pore problems, etc. by promoting the peeling of the skin .

Chemical peeling is mainly aimed at treating acne, pigmentation disorders, and diseases associated with photoaging, rejuvenating the skin, and cosmetically improving the skin such as spots, dullness, and texture. The basis of this treatment is the regeneration of the skin through the mechanism of wound healing, and the treatment must be based on dermatology.

Source: Japanese Dermatological Association Chemical Peeling Guidelines (Revised 3rd Edition) Japanese Dermatological Association Journal/Vol.118 (2008) No.3

General chemical peeling is a peeling agent that uses acids such as glycolic acid and lactic acid and herbs (herbal peeling such as green peel) to remove old keratin and dirt accumulated on the skin surface. It is often used to treat acne by promoting turnover, which is the metabolism of epidermal cells in the skin.

On the other hand, PRX-T33 does not cause the frosting effect, which is peeling of the skin, and the ingredients penetrate into the dermis, which is the layer below the epidermis, and the effect is obtained. By acting on the dermis, fibroblasts, which are the source of collagen production, are stimulated to produce new collagen and bring firmness to the skin .

Improves skin dryness, pore problems, and dullness

The skin is layered from the outside to the epidermis and dermis, but collagen, which affects the firmness and elasticity of the skin, is present in the dermis of the skin. When PRX-T33 penetrates into the dermis and stimulates the production of collagen, the proliferation of epidermal cells on the dermis is promoted, and the turnover cycle in which skin cells are reborn is established . You can expect to improve dryness, pore trouble, and dullness. In addition, you can expect the whitening effect of kojic acid.

PRX-T33 with extremely low risk to the human body

Medical devices in Japan are classified into four classes according to the risk to the human body in the "Medical Device Classification", but PRX-T33 belongs to "Class I", which has extremely low risk to the human body unapproved drug). In addition, safety is recognized because it has acquired the CE mark that proves that it meets the safety standards of the EU (European Union) member countries .

PRX-T33 is not the only treatment that stimulates the dermis to promote collagen production, but the method of stimulating the dermis is different. For example, fractional lasers, which are often used to treat acne scars by promoting the wound-healing power of the skin, encourage the production of collagen by making minute invisible holes in the form of dots with a laser. On the other hand, PRX-T33 penetrates the drug into the dermis and promotes collagen production.

In addition to fractional lasers, treatments that bring firmness to the skin include IPL treatment, high-frequency treatment, and injection treatments. However, it can be said that it is a treatment that is easy to receive.

Those who are suitable for PRX-T33 (massage peel/collagen peel)

  • Those who are concerned about sagging skin
  • Those who are concerned about fine wrinkles and dry skin
  • Those concerned about dullness
  • Those who are concerned about the loss of firmness and luster of the skin
  • I want to treat acne and acne scars
  • Those who want to improve open pores on the nose (strawberry nose)
  • Those who want to prevent or improve open pores and sagging pores
  • Those who want to increase firmness and elasticity and improve wrinkles on the neck
  • Those who are concerned about stretch marks and stretch marks
  • Those who are not suitable for conventional chemical peels
  • Those who are resistant to injections and irradiation treatments
  • Those who are new to aesthetic medicine
  • Those who cannot take downtime
  • Those who have difficulty in taking treatment time (short treatment time)

Areas that can be treated with PRX-T33 (massage peel/collagen peel)

It is possible to treat areas that are difficult to irradiate with machine skin treatment, such as the neck.

  • face
  • neck
  • decollete
  • aside
  • back of hand
  • bust
  • back
  • delicate zone
  • hip

Different effects of the three ingredients contained in PRX-T33 (massage peel)

PRX-T33 contains three ingredients, "high concentration TCA (trichloroacetic acid)", "low concentration hydrogen peroxide (H2O2)" and "kojic acid", each with different effects.

TCA promotes turnover and collagen production

Action on epidermis Activates epidermal cell growth factors, also known as keratinocytes, and promotes turnover , the metabolism of epidermal cells.
Action on dermis Bio-revitalizing action (promoting collagen production by increasing fibroblasts, which are the source of collagen production, and growth factors that promote the function of cells)

Trichloroacetic acid is abbreviated as TCA from the English notation "trichloroacetic acid" and accounts for 33% of PRX-T33. T33 in PRX-T33 means 33% TCA content.

When TCA penetrates the skin, it stimulates the dermis to produce collagen. However, when high concentrations of TCA are used to target collagen production, it tends to damage epidermal cells and cause pain and redness, making it a difficult formulation to handle.

Strict ingredient formulation of PRX-T33 (massage peel) is patented

High-concentration TCA has been used by limiting it to a single site due to side effects, but PRX-T33 uses a very strict pH value (degree of acidity and alkalinity) that has been patented in multiple countries such as Australia and Japan. ), by mixing low-concentration hydrogen peroxide, we have achieved the promotion of collagen production without causing a frosting effect . PRX-T33 is said to be an epoch-making prescription that can take advantage of the collagen-generating action of TCA .

TCA binds strongly to proteins, and loses its action by binding to proteins at the site of application. Therefore, although there are no systemic side effects from the standard application of chemical peels, they are localized and may cause scar formation. Injury to keratinocytes is concentration- and time-dependent. Low concentrations of TCA cause cytotoxicity slowly, while high concentrations of TCA cause early cytotoxicity.

Source: Japanese Dermatological Association Chemical Peeling Guidelines (Revised 3rd Edition) Japanese Dermatological Association Journal/Vol.118 (2008) No.3

Hydrogen peroxide protects skin

Action on epidermis Protects the skin by suppressing the strong peeling action of TCA
Action on dermis Supports the bio-revitalizing action of TCA

Hydrogen peroxide has the property of spreading in one direction, and when applied to the skin, it quickly penetrates the epidermal cells. PRX-T33 can promote collagen production while protecting the epidermis and dermis from stimulation by high-concentration trichloroacetic acid with low-concentration hydrogen peroxide.

When PRX-T33 is applied to the skin while massaging it, TCA and hydrogen peroxide penetrate the skin at different speeds.

Hydrogen peroxide has a high affinity with epidermal cells, so it quickly penetrates the shallow layers of the skin, while TCA slowly penetrates deep from the epidermis to the dermis. In this way, there is a time difference in the penetration speed, and TCA has the effect of promoting the production of collagen .

By using hydrogen peroxide at a low concentration of 0.15%, it supports the bio-revitalizing effect of TCA (promoting collagen production), but at a high concentration of 3%, the wound healing process may be prolonged. The concentration to be blended is important because

Prevention of post-inflammatory hyperpigmentation and whitening effect by kojic acid

PRX-T33 contains 5% Aspergillus oryzae, which can be expected to prevent post-inflammatory hyperpigmentation (PIH) caused by spots, dullness, and scars.

Whitening effect by chelating action

Melanin, which is the source of dark spots, changes to a black pigment when a substance called "tyrosine", which is a kind of amino acid, undergoes a chemical change. This change is activated when an enzyme called tyrosinase has copper ions, but kojic acid has a "chelating effect" that prevents activation by depriving tyrosinase of copper ions. Therefore, PRX-T33 can be expected to have a whitening effect by containing kojic acid.

Milan repeat with high concentration of TCA

In addition to PRX-T33, there is also "Milan Repeat" as a formulation containing a high concentration of TCA. The treatment effect is the same as PRX-T33, promoting collagen production.

Milano Repeat has different formulations for the face and body, with a TCA concentration of 35% for the face and 50% for the body, which is a higher concentration of TCA than PRX-T33. Also, other ingredients are different from PRX-T33, so PRX-T33 must be stored at 2°C to 8°C, but it can be stored at room temperature.

Treatment frequency and price of PRX-T33 (massage peel)

Recommended treatment frequency

With PRX-T33 , there are many people who can feel the effect of the skin with a single treatment, and immediate effects can be expected, but repeated treatments are recommended to further enhance and sustain the effect. increase.

As for the frequency of treatments recommended by the manufacturer, one course is 3 to 5 times, and it is recommended to receive treatments at intervals of 2 to 3 weeks for the face and 1 to 3 weeks for the body. It has been. As a guideline for maintenance after 1 course, if you feel that the effect has decreased (at least 6 to 8 weeks apart), perform 1 course again, and from the next month, receive treatment at intervals of once a month as maintenance. is recommended.

Price of PRX-T33 (massage peel)

Peeling treatment using PRX-T33 is a free medical treatment and is paid for in full. The price varies depending on the medical institution, but it is about 15,000 to 20,000 yen for the entire face treatment. Some medical institutions set a course with the recommended number of treatments of about 5 times.

full face About 15,000 yen to 20,000 yen
neck 10,000 to 15,000 yen
decollete About 20,000 yen
Back of hand (both hands) About 10,000 yen

Things to know before receiving PRX-T33 (massage peel)

I have a case that doesn't fit my skin

If you have a sensitive reaction to the compounded ingredients TCA and hydrogen peroxide, or if your skin is in poor condition due to rough skin, etc., you may feel pain or prolonged redness during the treatment .

If you feel any discomfort during the procedure, please inform the practitioner immediately. In addition, if redness, itching, or blisters occur after the treatment, anti-inflammatory agents such as steroids will be prescribed, so apply them according to the instructions.

There is a tingling sensation that PRX-T33 penetrates

For treatment, apply PRX-T33 and let it penetrate while massaging. By gradually penetrating, you may feel a tingling or burning sensation that you can endure . However, if you feel strong irritation, please tell the practitioner because it will be cured by wiping off the drug and cooling it.

Risks, side effects and downtime due to PRX-T33 (massage peel) treatment

There is almost no downtime, and makeup can be applied immediately after the treatment, but the skin after the treatment is easily irritated, so please take adequate moisturizing and UV protection. Also, if you have dry or sensitive skin, redness, wheals with red spots on the skin, and dry skin may occur, but in most cases it will subside within 1 to 2 hours after the treatment. In rare cases, it may take about a week for the redness to subside . In that case, please refrain from skin care that stimulates the skin, such as scrubs, until the redness subsides.

For several days after the treatment, skin cell turnover is promoted , and peeling and thin scabs may occur several days after the treatment. Pigmentation may occur if you remove it forcibly, so wait until it comes off naturally.

Precautions to be aware of before receiving PRX-T33 (massage peel)

  • Tretinoin must be withdrawn 2 weeks before starting PRX-T33
  • Permanent makeup may fade in color
  • Please remove accessories as there is a risk of discoloration

Those who cannot receive PRX-T33 (massage peel)

  • Those with skin inflammation, rash, or herpes rash
  • Those with sensitive skin
  • Areas of seborrheic dermatitis
  • Those with TCA, kojic acid allergy, or latex allergy
  • Those who are pregnant, may become pregnant, or are breastfeeding
  • Those with aspirin asthma or aspirin allergy
  • those who are sunburned
  • Those who are using hydroquinone, tretinoin, diferingel, duac-containing gel, bepiogel, epiduogel, or retinol (treatment is possible if use is stopped 2 weeks before treatment)
  • Those with diabetes, photosensitivity, heart disease, brain disease, or malignant tumors
  • Those with alcohol hypersensitivity
  • Those with acne or strong inflammation (atopy, etc.)
  • Those with photosensitivity

Reverse peel if you want specialized treatment for melasma

Reverse peel is a treatment that can be expected to improve melasma and pigmentation by adding a peeling treatment process with two drugs that act on melasma after PRX-T33.

PRX-T33 acts on the dermis, the second drug acts on the deep layers of the epidermis, and the third drug acts on the shallow layers of the epidermis, resulting in the excretion of melanin present in each skin layer. prompts

PRX-T33 (massage peel) is a drug not approved by the Ministry of Health, Labor and Welfare

PRX-T33 is an unapproved drug in Japan. Therefore, when considering treatment, understand the following points, and decide whether to perform treatment after receiving a full explanation about risks and side effects from a medical institution.

PRX-T33 is an unapproved drug in Japan.
Acquisition route of pharmaceuticals: The acquisition route is personal import from the manufacturer by the doctor of each medical institution.
About medicines to be careful about when importing for personal use (Ministry of Health, Labor and Welfare page)
Approval in Japan : There are no other drugs that have the same ingredients and effects as PRX-T33 and are approved in Japan.
Information on safety in other countries : According to the Italian developer WiQo med, it is registered as a medical device by the Italian Ministry of Health and has received the CE mark [*1].

The main risks and side effects that may occur include transient redness, wheals, dry skin, peeling, scabs, and pigmentation that occur at the treatment site.

[*1] Indicazioni PRX-T33 della linea WiQomed commercializzato da GPQ: WiQo med

Flow of PRX-T33 (massage peel) treatment

(1) Counseling

Counseling/examination to check skin condition. The doctor will explain the procedure to you. After cleansing and washing your face to remove makeup and dirt, wipe off the water thoroughly (because the treatment effect may be halved).

(2) Treatment with drug application and massage

Treatment is performed separately for the forehead, face line, and other parts. Massage the forehead and face line three times. Lightly apply the formulation to other parts. After massaging, gently wipe off the formulation and wash off with water. The massage time and strength are adjusted while checking the degree of stimulation by the drug, so if you feel pain or abnormality, please tell the practitioner.

(3) Sedation

Cool down redness and hot flashes and finish with a moisturizing cream. The treatment time is about 10 to 15 minutes, and makeup can be applied immediately after the treatment.

Why PRX-T33 (massage peel) should be taken at a medical institution instead of self

Massage peel PRX-T33, which promotes collagen production, has the effect of improving the lack of firmness

Some people buy PRX-T33 and try it at home, but if you do it yourself, it is difficult to get the same effect as if you received it at a medical institution .

There are treatments that can be used in combination with PRX-T33 (massage peel)

Since there are multiple treatments that can be used in combination at medical institutions, higher treatment effects can be expected due to synergistic effects.

There are some treatments that can be expected to have a synergistic effect when used in combination with PRX-T33. In some cases, it may be better to

Therefore, please check the treatment schedule with your medical institution.

Combined treatment with Dermapen 4, which is called velvet skin

The treatment that combines PRX-T33 and Dermapen 4 is also called velvet skin. Dermapen 4 is a treatment that promotes the wound healing power of the skin by intentionally creating a wound by moving a needle as thin as a hair up and down at high speed. If you perform a massage peel after the Dermapen 4 treatment, PRX-T33 will penetrate deep into the skin, and you can expect a higher treatment effect than with PRX-T33 alone.

Iontophoresis of active ingredients according to skin concerns

Iontophoresis is a treatment that introduces active ingredients into the skin using a device that sends a weak electric current.

Normally, human skin has a barrier function that prevents the intrusion of foreign substances from the outside, and the ingredients of skin care products such as lotions are limited to moisturizing the skin surface and do not penetrate deep into the skin.

In iontophoresis, if the drug to be introduced is negative, the negative electrode is applied to the skin, and if the drug is positive, the positive electrode is applied to the electrode. is.

Since the barrier function of the skin is temporarily weakened after treatment with a massage peel, you can expect the effect of iontophoresis of the active ingredient according to your skin concerns.

Skin problems you want to improve Ingredients introduced by iontophoresis
Improvement and whitening of acne Vitamin C
improvement of chloasma Tranexamic acid
open pores Glycylglycine
bring firmness Placenta, growth factor, hyaluronic acid

Irradiation treatment that can be expected to have a synergistic effect on collagen production

It is said that if PRX-T33 is performed during the treatment period in which energy such as IPL, laser, high frequency or HIFU is irradiated, the function of fibroblasts will be more activated and collagen production will be promoted.

Aftercare for PRX-T33 (massage peel)

After the treatment of PRX-T33, turnover, which is the metabolism of epidermal cells, is promoted, so peeling may occur several days after the treatment. It is recommended to sufficiently moisturize by using the PRX-T33 cream and serum at home, and the special cream and serum can be purchased at medical institutions.

WiQo moisturizing nourishing cream

A cream dedicated to PRX-T33 treatment with high moisturizing power that prevents moisture from evaporating. Normally, human skin has a barrier function that blocks invasion of bacteria from outside the body. Applying WiQo Moisturizing Nourishing Cream to the skin after PRX-T33 treatment, where the barrier function has weakened, will deliver nutrients while supporting the barrier function.

It is recommended to apply 2 to 3 times a day for several days after the treatment, and then 1 to 2 times a day thereafter.

WiQo face fluid (beauty essence)

It is recommended to use once a day from the night after the treatment. It can be expected to have the effect of making the skin acidic and enhancing and sustaining the treatment effect of PRX-T33.

It is an unapproved drug containing 5.6% glycolic acid. Since it cannot be used if redness, etc. remains on the skin, use it after the skin returns to normal. Apply after cleansing, leave for 30 minutes or more, then apply moisturizing nourishing cream.

*If the irritation is strong, do not overdo it and start leaving it for a short period of time every 2 to 3 days, and if it does not suit your skin, stop using it.

PRX-T33 (massage peel) that enhances the effect with appropriate massage

PRX-T33 is not a treatment that ends with just applying a drug.

Apply PRX-T33 to each area such as the forehead and cheeks and massage it into the treatment area. Redness and how pain is felt due to penetration of PRX-T33 varies from part to part, so it is confirmed each time, and the treatment is performed while changing the amount of PRX-T33 and the number of massages for thin and thick skin areas. increase.

The manufacturer recommends 1-2 times for areas with thin skin, and up to 5 times for areas with thick skin. The appropriate number of times is determined while checking.

Since the method of massage affects the effect of the treatment, there are many medical institutions where the doctor who developed the PRX-T33 directly teaches how to do it . Yes.

The difference between peeling received at an esthetic salon and a medical institution

According to a document released by the Ministry of Health, Labor and Welfare in 2000, it is clearly stated that chemical peeling, which uses drugs to artificially peel off the surface of the skin, falls under the medical practice. It has been shown that there are cases where chemical peels are provided by businesses that do not have.

References: Questions about the Medical Practitioners Act

Unlicensed businesses such as esthetic salons are prohibited from performing "chemical peeling", and for glycolic acid, if the pH is 3.0 or higher and the drug concentration is 10% or less, the treatment is possible. Even in the unlikely event that a skin problem occurs, it is safe to receive treatment under the doctor's diagnosis at a medical institution that can respond quickly.

Seiko Medical Beauty Clinic Massage Peel

We asked Ms. Seiko Soyama, who supervised the article, about massage peels.

What kind of skin symptoms and concerns are massage peels effective for?
Dr. Seiko Soyama
Effective for acne, mild acne scars, oily skin and dullness. It is also recommended for those who seek firmness and luster.
Are there any precautions to take when receiving a massage peel?
Dr. Seiko Soyama
It is not recommended when the skin barrier function is significantly degraded. Also, if you are using tretinoin or high-concentration retinol, you need to take a week to two weeks off.
How much downtime is there?
Dr. Seiko Soyama
Redness is usually mild and disappears on the same day. Mild peeling occurs after 2 to 3 days, but subsides in a few days.
Please tell me why it is better to do a massage peel at a beauty clinic than to do it yourself.
Dr. Seiko Soyama
Peeling is a medical procedure. First of all, it is necessary to examine whether the massage peel is really suitable, and it may cause unexpected side effects, so be sure to do it at a medical institution. A skilled medical worker must check the skin condition during the procedure.
How often and how many times should I do a massage peel to make my pores less noticeable?
Dr. Seiko Soyama
It depends on the cause of conspicuous pores, and there are large individual differences due to various factors such as age, gender, and skin condition. Depending on the results, we will consider whether to continue treatment at the same pace until satisfactory results are obtained, or to terminate once.
Thank you very much, Mr. Soyama!

[For medical professionals] Massage peel Q&A with Dr. Seiko Soyama

We asked Ms. Seiko Soyama, who supervised the article, about massage peels.

After how many days can tretinoin be restarted after massage peel treatment?
Dr. Seiko Soyama
If the skin condition is calm, it is possible after one week.
Should I avoid massage peels for people with atopy or sensitive skin?
Dr. Seiko Soyama
We recommend that you treat atopy and sensitive skin first, and then treat after the barrier function has been restored.
How long should I leave the space between the massage peel and the laser?
Dr. Seiko Soyama
If the skin condition is calm, it is possible from 2 weeks later.
Are massage peels effective for acne and acne scars? How often and how many times should it be done?
Dr. Seiko Soyama
Effective for acne and minor acne scars. It is recommended to have "5 times every 2 to 3 weeks for 1 course". As with pore improvement, evaluate once in one course and consider whether to continue or end.
Dermapen 4 can be given as a treatment that is more effective when used in combination with a massage peel, but are there any other treatments that are more effective when used together?
Dr. Seiko Soyama
At our hospital, we may perform Nd:Yag laser (Genesis) at the same time. The following synergistic effects can be expected.

(1) Improve fine wrinkles, open pores, and acne scars by further promoting collagen growth in the dermis with Genesis
(2) Improvement of acne and dullness by removing accumulated keratin by the action of laser peeling and improving turnover disturbance.

In addition, Genesis also works to constrict dilated blood vessels, so it can be expected to be effective in improving redness.
Thank you very much, Mr. Soyama!

Introduction of supervising doctor

Dr. Seiko Soyama, Chairman of Seiko Medical Beauty Clinic. As a beauty specialist, she has appeared in the media many times, and has contributed many articles to "Latest Aesthetic Dermatology Treatment Navigation" and "Non-Surgical Aesthetic Medicine Super Practical Lectures." In addition, the clinic has a policy of meticulous examination, such as fully equipped treatment rooms with completely private rooms, as well as a kids' room and a men-only room.

Medical institution with Dr. Seiko Soyama

Seiko Medical Beauty Clinic Seiko Medical Beauty Clinic Kagoshima
Seiko Medical Beauty Clinic Fukuoka
Contact information for Kagoshima Temple: 0120-172-117
Contact information for Fukuoka-in: 0120-126-265