PRX-T33 is also called "massage peel" or "collagen peel" because it is applied to the skin and massaged to permeate the ingredients and promote collagen production .
PRX-T33 is one of the treatments that even those who are new to cosmetology can easily receive because you can feel the effect of tightening the skin immediately after the treatment and the treatment of permeating the ingredients with a massage is easy to understand. In addition, if you are already receiving cosmetology, the effect may be enhanced by using PRX-T33 together with the current treatment.
By knowing the effects of PRX-T33, the frequency and frequency of treatments, and the treatments that are more effective when used in combination, you can aim for efficient improvement of skin quality.
Table of contents
PRX-T33 is a product of WiQo med of Italy, and was developed by Dr. Rossana Castellana as a peeling agent for medical institutions after more than 10 years of clinical research.
Chemical peeling is a treatment that removes old keratin and waste products by applying a drug to the skin and peeling it off. Although PRX-T33 is a type of peeling, it does not cause frosting action and promotes collagen production. By applying PRX-T33 to the skin and infiltrating it while massaging, old collagen is replaced with new collagen and the skin becomes firm, so fine wrinkles, pore openings, acne and acne scars are improved during facial treatment. , If it is a treatment on the body, improvement of the pregnancy line can be expected.
Since the word peeling originally means "peeling", the action of chemical peels is to remove dead skin cells on the surface of the skin . It is a treatment that aims to improve dullness, rough skin, pore troubles, etc. by promoting peeling of the skin .
Chemical peels are mainly intended for the treatment of acne, pigmentation abnormalities, and sickness associated with photoaging, and for the cosmetic improvement of skin such as skin rejuvenation, age spots, dullness, and texture. The basis is the regeneration of the skin by the wound healing mechanism, and the treatment based on dermatology must be performed.
A common chemical peel is a peeling agent that uses acids such as glycolic acid and lactic acid and herbs (herbal peels such as green peel) to remove old keratin and dirt accumulated on the skin surface. It is often used to treat acne by promoting turnover, which is the metabolism of epidermal cells in the skin.
On the other hand, PRX-T33 does not cause the frosting action, which is the peeling of the skin, and the ingredients penetrate into the dermis, which is the lower layer of the epidermis, and the effect is obtained. By acting on the dermis, the fibroblasts that produce collagen are stimulated, new collagen is produced, and the skin becomes firm .
The skin is layered from the outside to the epidermis and dermis, but collagen, which affects the firmness and elasticity of the skin, is present in the dermis of the skin. When PRX-T33 penetrates into the dermis and its stimulation promotes collagen production, the proliferation of epidermal cells above the dermis is promoted, and the turnover cycle in which skin cells are reborn is arranged , and the skin's skin It can be expected to improve dryness, pore trouble and dullness.
Medical devices in Japan are classified into four classes according to the risk to the human body in the "Medical device classification", but PRX-T33 belongs to "Class I", which has extremely low risk to the human body. In addition, safety is recognized because it has obtained the CE mark certifying that it meets the safety standards of EU (European Union) member states .
PRX-T33 is not the only treatment that stimulates the dermis to stimulate collagen production, but the method of stimulating the dermis is different. For example, fractional lasers, which are often used to treat acne scars by boosting the healing power of the skin, stimulate collagen production by making punctate, invisible, microscopic holes in the laser. PRX-T33, on the other hand, allows the drug to penetrate the dermis and promote collagen production.
In addition to fractional laser, there are IPL treatment, high frequency treatment and injection treatment as treatments that bring firmness to the skin, but from the viewpoint of safety , those who are new to cosmetology or who are resistant to injection treatment and irradiation treatment However, it can be said that the treatment is easy to receive.
It is possible to treat areas such as the neck that are difficult to irradiate with a machine for skin beautification.
PRX-T33 contains three components, "high concentration TCA (trichloroacetic acid)", "low concentration hydrogen peroxide (H2O2)" and "kojic acid", each of which has a different action.
|Action on the epidermis||Activates epidermal growth factors, also known as keratinocytes, and promotes turnover, which is the metabolism of epidermal cells.|
|Action on the dermis||Bio-vitalizing action (promoting collagen production by proliferating fibroblasts, which are the sources of collagen, and growth factors that promote the function of cells)|
Trichloroacetic acid is abbreviated as TCA from the English notation "trichloroacetic acid" and accounts for 33% of PRX-T33. T33 of PRX-T33 means that it contains 33% TCA.
When TCA penetrates the skin, it stimulates the dermis to produce collagen. However, when high-concentration TCA is used for collagen production, it tends to cause pain and redness due to damage to epidermal cells , so it has been regarded as a difficult preparation.
It is a high-concentration TCA that has been used to limit it to a part because it has side effects, but PRX-T33 has a very strict pH value (degree of acidity and alkalinity) that has been patented in multiple countries such as Australia and Japan. By mixing a low concentration of hydrogen peroxide in), collagen production was promoted without causing frosting action . PRX-T33 is said to be an epoch-making formulation that can utilize the collagen-producing action of TCA .
TCA has a strong bond with the protein and loses its action by binding to the protein at the application site. Therefore, there are no systemic side effects due to the standard application of chemical peels, but they are strong locally and may cause scarring. Injury to keratinocytes is concentration-time dependent, with low-concentration TCA slowly causing cytotoxicity, but high-concentration TCA showing early cytotoxicity.
|Action on the epidermis||Protects the skin by suppressing the strong peeling action of TCA|
|Action on the dermis||Supports bio-revitalizing action by TCA|
Hydrogen peroxide has the property of spreading in one direction, and when applied to the skin, it quickly penetrates into epidermal cells. PRX-T33 can promote collagen production while protecting the epidermis and dermis from irritation by high concentrations of trichloroacetic acid with low concentrations of hydrogen peroxide.
When PRX-T33 is applied to the skin while massaging, TCA and hydrogen peroxide penetrate the skin at different speeds.
Hydrogen peroxide has a high affinity for epidermal cells, so it quickly penetrates the shallow layers of the skin, and TCA slowly and deeply penetrates from the epidermis to the dermis. In this way, the time difference in penetration speed provides the effect of promoting collagen production by TCA .
By using hydrogen peroxide at a low concentration of 0.15%, it supports the biorevitalizing action (promotion of collagen production) by TCA, but at a high concentration of about 3%, it prolongs the process of wound healing. The concentration to be blended is important because it will cause collagen peroxide.
PRX-T33 contains 5% Koji bacteria and can be expected to have the effect of preventing post-inflammatory hyperpigmentation (PIH) due to spots, dullness, scars, etc.
Melanin, which is the source of stains, changes to a black pigment when a substance called "tyrosine", which is a type of amino acid, undergoes a chemical change. This change is activated when an enzyme called tyrosinase has copper ions, but kojic acid has a "chelating effect" that blocks the activation by depriving tyrosinase of copper ions. Therefore, PRX-T33 can be expected to have a whitening effect because it contains kojic acid.
In addition to PRX-T33, there is "Milan Repeat" by C Med Aesthetics Srl of Italy as a preparation containing a high concentration of TCA. Similar to PRX-T33, the treatment effect is to promote collagen production.
Milan Repeat has different formulations for face and body, with TCA concentration of 35% for face and 50% for body, which is higher than PRX-T33. Also, since other ingredients are different from PRX-T33, PRX-T33 must be stored at 2 ° C to 8 ° C, but it can be stored at room temperature.
PRX-T33 can be expected to have immediate effect because the face line is tightened and the lift-up effect can be felt even with one treatment .
It is a treatment that some people repeat because the effect can be seen immediately after the treatment, and it is generally recommended to receive the treatment once a week for 1 to 5 times in a row. Since the treatment promotes the production of collagen, the treatment effect continues for several months after the treatment.
Peeling treatment using PRX-T33 is a free medical treatment and you are responsible for all costs. The fee varies depending on the medical institution, but it is about 12,500 to 18,000 yen for the entire face treatment. Some medical institutions set the course with 5 times, which is the recommended number of treatments.
If you are sensitive to the ingredients TCA or hydrogen peroxide solution, or if your skin is in poor condition due to rough skin, you may feel pain or prolong redness during the procedure .
If you feel any abnormalities during the procedure, please inform the practitioner immediately. If you experience redness, itchiness, or blisters after the procedure, anti-inflammatory agents such as steroids will be prescribed, so apply according to the instructions.
For the treatment, apply PRX-T33 and let it penetrate while massaging. As it gradually penetrates , you may feel a tingling sensation or a feeling of heat that you can endure . However, since the medicine is wiped off and cooled, please inform the practitioner if you feel a strong stimulus.
There is almost no downtime and you can make up immediately after the procedure, but the skin after the procedure is susceptible to irritation, so please take sufficient moisturizing and UV protection. If you have dry or sensitive skin, you may experience redness, urticaria with red spots on the skin, and dry skin, but most of the time it will subside within 1 to 2 hours after the procedure. In rare cases, it may take up to a week for the redness to subside . In that case, please refrain from skin care that irritates the skin such as scrubbing until the redness subsides.
During the first few days after the procedure, the skin cells may be reborn and the turnover may be promoted , resulting in peeling and thin scabs several days after the procedure . If you forcibly peel it off, pigmentation may occur, so wait until it peels off naturally.
Riverspill is a treatment that can be expected to improve chloasma and pigmentation by adding a peeling treatment process with two drugs that act on chloasma after PRX-T33.
PRX-T33 acts on the dermis, the second drug acts on the deep layers of the epidermis, and the third drug acts on the shallow layers of the epidermis, thereby excreting melanin present in each skin layer. Prompt.
PRX-T33 is an unapproved drug in Japan. Therefore, please understand that there are the following points to be noted when considering the treatment, and decide whether to perform the treatment after receiving sufficient explanation about the risks and side effects at the medical institution.
|PRX-T33 is a domestic unapproved medical device.|
| Drug acquisition route: The acquisition route is individual import from the manufacturer by the doctor of each medical institution.|
Drugs that should be noted in personal imports (Ministry of Health, Labor and Welfare page)
|Approval in Japan : There are no other drugs that have the same ingredients and actions as PRX-T33 and have been approved in Japan.|
| Information on safety in other countries : According to the developer, WiQo med of Italy, it is registered as a medical device by the Italian Ministry of Insurance and has obtained the CE mark [* 1].|
The main risks and side effects that can occur include transient redness, wheals, dry skin, peeling, scabs, and pigmentation that occur at the treatment site.
Cleanse the makeup, check the condition of the patient's skin, and receive an explanation from the doctor and the doctor about the procedure. After that, cleanse the makeup and wipe off the water as the treatment effect may be halved.
(2) Treatment by applying medicine and massaging
The time and intensity of the massage will be adjusted while checking the degree of stimulation by the drug, so if you feel any pain or abnormality, please inform the practitioner.
Cools down redness and hot spots, moisturizes and conditions the skin. The treatment time is about 10 to 15 minutes.
Some people buy the PRX-T33 and try it at home, but if you do it yourself, it is difficult to get the same effect as if you received it at a medical institution .
Since there are multiple treatments that can be used together at medical institutions, a higher treatment effect can be expected due to the synergistic effect.
There are some treatments that can be expected to have a synergistic effect when used in combination with PRX-T33, but if the redness of the skin becomes strong after the treatment with PRX-T33, receive it on a different day instead of the same day as PRX-T33. In some cases, it is better to use it.
Therefore, please check with your medical institution for the treatment schedule.
The treatment that combines PRX-T33 and Dermapen 4 is also called velvet skin. Dermapen 4 is a treatment that promotes the healing power of skin wounds by intentionally creating wounds by moving a needle as thin as a hair up and down at high speed. If you perform a massage peel after the Dermapen 4 treatment, the PRX-T33 will penetrate deep into the skin, and you can expect a higher treatment effect than if you perform the PRX-T33 alone.
Iontophoresis is a procedure that introduces the active ingredient into the skin using a device that conducts weak electricity.
Normally, human skin has a barrier function that prevents foreign substances from entering from the outside, and the ingredients of skin care products such as lotion only have a moisturizing effect on the surface of the skin and do not penetrate deep into the skin.
In the treatment by iontophoresis, if the drug to be introduced is negative, a negative electrode is applied to the skin, and if it is positive, a positive electrode is applied so that the active ingredient repelled by the electrode reaches deep into the skin beyond the barrier function of the skin. is.
Since the barrier function of the skin after treatment with massage peel is temporarily weakened, the effect of iontophoresis of the active ingredient can be expected according to the skin's problems.
|Skin problems that I want to improve||Ingredients introduced by iontophoresis|
|Acne improvement and whitening||Vitamin C|
|Improvement of chloasma||Tranexamic acid|
|Opening of pores||Glycylglycine|
|Bring tension||Placenta, growth factor, hyaluronic acid|
It is said that PRX-T33 is performed during the treatment period of irradiation with energy such as IPL, laser, high frequency and HIFU to further activate the function of fibroblasts and promote collagen production.
After PRX-T33 treatment, turnover, which is the metabolism of epidermal cells, is promoted, so peeling may occur several days after the treatment. It is recommended that you use the PRX-T33 cream and serum at home to keep your skin moisturized, and you can purchase the cream and serum at a medical institution.
A cream for PRX-T33 treatment with high moisturizing power, which has the effect of preventing the evaporation of water. Normally, human skin has a barrier function that blocks the invasion of bacteria from outside the body. When WiQo Moisturizing Nourishing Cream is applied to the skin after PRX-T33 treatment, which has a weakened barrier function, nutrients are delivered while supporting the barrier function.
It is recommended to apply 2-3 times a day for several days after the procedure, and then 1-2 times a day thereafter.
It is recommended to use once a day from the day after the procedure. It can be expected to moisturize the skin and enhance and sustain the treatment effect of PRX-T33.
PRX-T33 is not just a treatment that is completed by applying a drug.
Apply PRX-T33 to each part of the treatment area, such as the forehead and cheeks, and let it penetrate with a massage. Since the feeling of pain caused by redness and PRX-T33 penetration differs from site to site, check each time and perform the treatment while changing the amount of PRX-T33 and the number of massages in the thin and thick areas of the skin. I will.
Although the manufacturer has indicated the standard number of times, such as once or twice for thin skin areas and up to 5 times for thick skin areas, the feel of the massage and the firmness of the skin can be seen. The appropriate number of times will be judged while checking.
Since the method of massage affects the treatment effect, many medical institutions directly learn how to do it from the doctor of the PRX-T33 developer, and PRX-T33 is a medical institution, and it is said that the treatment effect can be obtained by receiving an appropriate massage. I can say.
According to the material released by the Ministry of Health, Labor and Welfare in 2000, it is clearly stated that chemical peeling that artificially peels off the surface layer of the skin using chemicals is a medical practice, but on the other hand, a doctor's license such as an esthetic salon It is shown that there are cases where chemical peels are provided by businesses that do not have.
References: Questions under the Medical Practitioners Act
It is forbidden for non-doctors such as beauty salons to perform "chemical peeling", and it is possible to perform treatment if glycolic acid has a pH of 3.0 or higher and a drug concentration of 10% or lower. In the unlikely event that a skin problem occurs, it is safe to receive treatment under the diagnosis of a doctor at a medical institution that can respond quickly.
(Updated January 2021)