
Lipolytic injection is a cosmetological procedure that can aim for slimming by destroying fat cells and reducing the number of fat cells in the body .
Previous lipolytic injections were prone to swelling after treatment and most drugs had long downtime, but with the development of new drugs from various manufacturers, swelling after treatment is less likely to occur and downtime is also reduced. Due to the shortening, the number of drugs that can be injected not only into the body but also into the face has increased recently.
The components and actions of lipolytic injection differ depending on the type of drug, and if the treatment is performed with an inappropriate injection amount, there is a risk that the cheeks may appear smoldering due to an excessive decrease in fat cells . In order to aim for a smaller face with more peace of mind by lipolytic injection into the face, it is important to know in advance the characteristics of each drug, the appropriate injection amount for each facial part, and the risks .
Lipolytic injection that can be expected to reduce subcutaneous fat
Subcutaneous fat, which is present on the face line, cheeks, upper arms, abdomen, and thighs, is one of the adipose tissues made up of multiple fat cells . Fat cells have the function of storing the ingested energy as fat, and the more energy is stored, the larger the cells become, making them obese and making their faces look swollen .
A general diet such as exercise and dietary restriction aims at face thinning and slimming by reducing the enlarged fat cells, but since the number of fat cells itself does not decrease, excessive energy intake was performed. There is a risk that it will become bloated again and rebound.
On the other hand, lipolytic injection is a procedure that reduces the number of adipocytes by injecting into adipose tissue a drug that can be expected to destroy the adipocytes themselves or promote their excretion from the body. Since the fat cells that are destroyed and excreted from the body do not return to their original state, it is said to be a treatment that is less likely to rebound than the slimming method that reduces the size of the fat cells.
Various types of lipolytic injection drugs have been developed by various manufacturers, and each has a different action to reduce fat cells and the period of downtime after treatment, and some drugs are mainly injected into the face. ..
Major lipolytic injection drugs that can be injected into the face

List of major lipolytic injection drug names
Drug name | Maker | Main ingredients |
---|
Alfocholine | Daewon Pharmaceutical (Korea) | Plant-derived ingredients |
Cavelin | NewFace Laboratories (Korea) | Deoxycholic acid |
Michelangelo | Renaissance srl Beauty Through Art (Italy) | Phosphatidylcholine / deoxycholic acid |
Contour injection | SMIL DIET (Spain) | Plant-derived ingredients |
BNLSneo | GRAND M & C (Korea) | Plant-derived ingredient, deoxycholic acid |
MITI | HANS PHARMA (Korea) | Phosphatidylcholine / deoxycholic acid |
The main components of lipolytic injections are divided into three parts:
It is the main component of lipolytic injection called "Kaibella", which is not used in Japan, and has the effect of destroying the cell membrane of adipocytes and reducing adipocytes, which is approved by the US FDA (US Food and Drug Administration) . When destroying the cell membrane, it has the disadvantage of causing inflammation at the injection site .
- Phosphatidylcholine (PPC)
Unlike deoxycholic acid, it is not an ingredient whose efficacy has been approved by the FDA or other public institutions, but it has been shown to reduce subcutaneous fat in numerous clinical data. Although the specific mechanism that leads to the decrease of fat cells has not been elucidated, it is a component that has the disadvantage of causing inflammation at the injection site like deoxycholic acid.
- Ingredients derived from plants (walnuts, seaweed, etc.)
It is a component of a drug that appeared after deoxycholic acid and phosphatidylcholine, and it is said that extracts extracted from plants such as walnuts and seaweed can be expected to be effective in reducing subcutaneous fat . Although there is no official approval for plant-derived ingredients, clinical data have confirmed a reduction in subcutaneous fat, and compared to drugs containing deoxycholic acid or phosphatidylcholine as the main components, after injection. It tends to be less prone to inflammation .
Alfocholine
It is a drug whose main component is extracted from soybeans and whose safety is approved by KFDA (Ministry of Food and Drug Safety) . The active ingredient that is expected to act on fat cells is glycerophosphocholine (GPC), which is also contained in human breast milk . Glycerophosphocholine used in alfocholine is produced from lecithin, one of the lipids in soybeans.
Since it is not a drug based on deoxycholic acid or phosphatidylcholine, it is said that swelling and pain are less likely to occur after injection.
Cavelin
Deoxycholic acid, which acts directly on adipocytes, is the active ingredient, but the addition of artichoke extract, which has the effect of improving lymphatic flow and blood flow, causes swelling compared to conventional lipolytic injections containing deoxycholic acid. It is a drug developed to reduce the amount .
In addition, since artichoke extract also has a function of promoting metabolism, it can be expected to have an effect of facilitating the excretion of fat cells destroyed by deoxycholic acid. In addition to deoxycholic acid and artichoke extract, it also contains L-carnitine, which is a type of amino acid mainly contained in meat, and L-carnitine has a function of promoting energy conversion of fat when exercising. It is an ingredient that is made.
Michelangelo
Deoxycholic acid and phosphatidylcholine are active ingredients . In addition, it contains L-carnitine, which is a type of amino acid, caffeine, which has vasodilatory and diuretic effects, and α-lipoic acid, which has antioxidant effects.
L-carnitine promotes the energy consumption of triglycerides released from destroyed fat cells, and caffeine, which has a diuretic effect, helps the destroyed fat cells to be excreted as urine by metabolism. It is an ingredient. Since α-lipoic acid has an effect of increasing metabolism in addition to an antioxidant effect, it can be expected to promote the excretion of destroyed fat.
Contour injection
Saponin, α-linolenic acid, Hibamata component, and tyrosine, which are plant-derived (medical herb) extracts, are active ingredients. Not only does it aim to reduce fat at the injection site, but it also contains ingredients that can be expected to be firming .
Drugs containing medical herbs as the main component, such as contour injection, are said to have a milder effect on reducing fat than drugs containing deoxycholic acid or phosphatidylcholine as the main components. On the other hand, it is less likely to cause pain and swelling after injection, so it tends to be used for lipolytic injection into the face .
BNLS neo
BNLS neo, the third generation of the series developed after the first BNLS and BNLS Version 2, is a combination of deoxycholic acid and BNLS, which is mainly composed of conventional medical herbs . It is a drug that is said to have a stronger fat-reducing effect due to the addition of deoxycholic acid, which has been recognized by the FDA as having a fat-reducing effect.
Among the fat dissolving injections currently performed in Japan, it is considered to be a drug that does not cause pain and swelling after injection, and many medical institutions use it as a fat dissolving injection to the face .
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MITI
Phosphatidylcholine is the active ingredient drug. In addition to phosphatidylcholine, which is a component that acts on fat cells, it contains IGF-1 (insulin-like growth factor) that activates metabolism and muscles, and it is expected that the number of fat cells present at the injection site will decrease. At the same time, it is a drug that can be expected to firm the skin .
Compared to drugs whose main component is a plant-derived extract, the action of phosphatidylcholine is characterized by swelling and pain after injection.
Types of face thinning and injection amount that can be expected from lipolysis injection

A small face that can be aimed at by lipolytic injection on the face line and cheeks
If the face looks large due to subcutaneous fat on the face line and cheeks, lipolytic injections on the face line, cheeks, or both can be expected to have a small face effect by reducing fat cells .
The standard injection amount for each treatment is 2cc to 4cc for the face lines on both sides and 2cc to 8cc for both cheeks . When performing lipolytic injections on the face line and cheeks, if the amount of the drug injected is too large, there is a risk that the cheeks will become sick and look older than the actual age due to the excessive decrease of fat cells. Therefore, it is important to decide the injection amount in consultation with your doctor.
Improvement of dumpling nose that can be aimed at by lipolytic injection into the nose
If the tip of the nose is rounded or the nose is widened laterally due to subcutaneous fat, reducing fat by lipolytic injection can be expected to have the effect of passing the nasal muscles and shrinking the nose. ..
The guideline for the amount of injection is 1cc to 2cc for the tip of the nose and 0.5cc to 1.5cc for the nose part per treatment. Other treatments that can be expected to improve the dumpling nose include inserting a silicone artificial cartilage under the skin of the nose and inserting a prosthesis through the nasal muscles, or incising the skin of the nose and then sewing the cartilage with a thread to bring it to the center. There is nose tip formation aiming at the ideal shape of the nose tip.
Improvement of double chin that can be aimed at by lipolytic injection under the jaw
By injecting lipolysis under the chin, the subcutaneous fat under the chin can be reduced and the double chin can be improved . The standard injection amount for each treatment is 3cc to 5cc, but if the cause of the double chin is not subcutaneous fat but sagging skin, a special thread is inserted into the skin to physically Other treatments such as thread lift to raise slack are indicated.
Precautions when injecting lipolysis into the face

Risk of lipolytic injections on the face
Lipolytic injection has a shorter downtime than surgical treatment and is a relatively easy-to-use cosmetological treatment, but it is important to know the risks in advance in order to receive the treatment with greater peace of mind. There are two risks associated with lipolytic injections in the face :
Internal bleeding may occur
Since lipolytic injection is a procedure in which a drug is injected subcutaneously, internal bleeding may occur if the capillaries are damaged during the injection . It is said that even if internal bleeding occurs, it will usually be settled in about 1 to 2 weeks, but just in case, adjust the schedule so that you do not have an important schedule for about 1 to 2 weeks after receiving the treatment. It is safe to keep it.
The skin at the injection site tends to sag
The skin that was stretched by the enlarged fat cells becomes easier to sag by reducing the fat cells by lipolytic injection and eliminating the tension . Some drugs contain ingredients that prevent sagging, but they are said to be easier to sag than people who have never had a lipolytic injection.
If the skin sags due to a decrease in fat cells, a thread lift that inserts a thread into the face and physically pulls up the skin can be expected to improve the sagging. In addition, treatments such as Thermacool and Ursera, which tighten proteins such as collagen fibers in the skin by irradiating the dermis layer, which is the base of the skin, and the subcutaneous tissue, which is the fat layer, with high-frequency and ultrasonic waves, are also sagging. You can expect improvement.
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Pain and downtime during lipolytic injections on the face
Lipolytic injection pain
Since it is an injection procedure, pain will occur when inserting the injection needle subcutaneously, but anesthesia is also possible , so if you are worried about the pain, please consult a doctor. It is also possible to reduce pain by using a needle with a rounded tip called a cannula .
Some medical institutions have an option menu for anesthesia and cannula use, so please contact each medical institution for prices.
Lipolytic injection downtime
Lipolytic injections have different downtimes for the swelling and internal bleeding at the injection site to subside, depending on the type of drug. Some drugs have almost no downtime, while others have a week or two of downtime .
Lipolytic injection is an unapproved drug in Japan
Currently, none of the lipolytic injection drugs used in Japan have been approved by the Ministry of Health, Labor and Welfare . When performing lipolytic injection, it is important to receive a thorough explanation of the risks, precautions, and expected effects at the medical institution, and to be convinced before receiving the treatment.
Those who cannot receive lipolytic injection
- Those with thyroid disease
- Those who are allergic to the ingredients contained in the drug
- Pregnant and lactating
- Those who are undergoing anti-cancer drug treatment
- Those with unhealed trauma or inflammation in or around the treatment area
- Those with immunodeficiency diseases, those with autoimmune diseases
- Those with microangiopathy or vascular insufficiency
- Those who have been drinking on the day of the treatment
- Those who are judged to be maladaptated by other medical institutions undergoing treatment
Treatments other than lipolysis injection that can be expected to cause face thinning due to fat loss

Liposuction
Liposuction is a surgical procedure that physically removes fat from the body by inserting a tube into the part where you want to reduce fat and sucking fat.
It is said that the pain after surgery is only felt when moving the face such as opening the mouth or washing the face, and not as much as taking painkillers. In addition, although the surgery involves internal bleeding, it often subsides within 1 to 2 weeks, and swelling tends to continue after surgery for about 1 month .
Buccal fat removal technique
Buccal fat is the adipose tissue under the masseter muscle of the cheek, which is different from subcutaneous fat. If you have a lot of buccal fat, your cheeks may appear bulging or your entire face may appear bulging.
In buccal fat removal surgery, the inside of the cheek is incised about 5 mm to 1 cm, and the buccal fat is removed by picking it out from the incision, so the wound after surgery is not visible . You can expect thinning of the face by removing the buccal fat that makes the cheeks and the entire face look bulging.
Ultra accent
Ultra Accent is an ultrasonic machine that can be expected to destroy fat cells. By irradiating ultrasonic waves that react only with fat cells, you can expect the effect of destroying only fat cells without damaging blood vessels and lymph vessels . The destroyed fat cells are carried by the bloodstream and lymph vessels and excreted as urine and stool, making it possible to aim for face thinning.
Methods and treatments to enhance the effect of lipolytic injection

Subcutaneous fat can be expected to decrease even with lipolytic injection, but there are methods and cosmetological treatments that can be expected to further reduce subcutaneous fat after the procedure.
How to improve the effect of lipolytic injection after treatment
Massage
It is said that a gentle massage after the treatment spreads the injected drug over a wide area and makes it more effective . However, if you have pain or immediately after the procedure, it may cause inflammation, so please refrain from massaging until symptoms such as pain and swelling subside.
aerobic exercise
By doing aerobic exercise, you can improve your body's metabolism. Since the fat cells destroyed by lipolysis injection are excreted from the body by the metabolism of the body, the function of excreting the fat cells from the body is promoted by increasing the metabolism, and it becomes easier to realize the effect .
Treatment that can be expected to have a synergistic effect when used in combination with lipolytic injection
Lymph drainage that smoothes the flow of lymph vessels
Lipolytic injections destroy fat cells, but the destroyed fat cells are carried by the flow of blood and lymph and excreted as urine and stool. By improving the flow of lymph by a massage called lymph drainage, you can expect the effect of smoothing the discharge of destroyed fat cells .
Botulinum injection that weakens the masseter muscle that causes gills
If the cause of the gills appearing to be stretched is not the subcutaneous fat but the excessive development of the facial muscles called the masseter muscles, lipolytic injection cannot be expected to improve. Gill caused by the development of the masseter muscle can be expected to improve by relaxing the masseter muscle by injecting botulinum, which has the effect of relieving the tension of the muscle at the injection site .
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How to choose a medical institution to avoid failure with lipolytic injections into the face

When performing lipolytic injections on the face, the location and amount of the drug to be injected are important depending on how the fat is attached to the face . If the location and amount of the drug is inadequate, there is a risk that the effect will not be felt and that there will be a difference in the amount of fat loss between the left and right.
Doctors who are familiar with how to get fat on the face tend to also perform liposuction surgery, so by receiving liposuction injection at a medical institution where a doctor with a large number of liposuction procedures is enrolled , It is possible to aim for face thinning while reducing the risk of failure .
When performing lipolytic injections into the face, use undiluted undiluted drug . In the unlikely event that a drug diluted with the undiluted solution is used despite the fat dissolving injection into the face, there is a possibility that the effect will be hardly felt. Please check at.