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Risk of lipolytic injection, injection amount, type of drug that can aim for face thinning such a...




Lipolytic injection is a cosmetological procedure that can aim for slimming by destroying fat cells and reducing the number of fat cells in the body .

Previous lipolytic injections were prone to swelling after treatment and most drugs had long downtime, but with the development of new drugs from various manufacturers, swelling after treatment is less likely to occur and downtime is also reduced. Due to the shortening, the number of drugs that can be injected not only into the body but also into the face has increased recently.

The components and actions of lipolytic injection differ depending on the type of drug, and if the treatment is performed with an inappropriate injection amount, there is a risk that the cheeks may appear smoldering due to an excessive decrease in fat cells . In order to aim for a smaller face with more peace of mind by lipolytic injection into the face, it is important to know in advance the characteristics of each drug, the appropriate injection amount for each facial part, and the risks .

Lipolytic injection that can be expected to reduce subcutaneous fat

Subcutaneous fat, which is present on the face line, cheeks, upper arms, abdomen, and thighs, is one of the adipose tissues made up of multiple fat cells . Fat cells have the function of storing the ingested energy as fat, and the more energy is stored, the larger the cells become, making them obese and making their faces look swollen .

A general diet such as exercise and dietary restriction aims at face thinning and slimming by reducing the enlarged fat cells, but since the number of fat cells itself does not decrease, excessive energy intake was performed. There is a risk that it will become bloated again and rebound.

On the other hand, lipolytic injection is a procedure that reduces the number of adipocytes by injecting into adipose tissue a drug that can be expected to destroy the adipocytes themselves or promote their excretion from the body. Since the fat cells that are destroyed and excreted from the body do not return to their original state, it is said to be a treatment that is less likely to rebound than the slimming method that reduces the size of the fat cells.

Various types of lipolytic injection drugs have been developed by various manufacturers, and each has a different action to reduce fat cells and the period of downtime after treatment, and some drugs are mainly injected into the face. ..

Major lipolytic injection drugs that can be injected into the face

Several drugs

List of major lipolytic injection drug names

Drug name Maker Main ingredients
Alfocholine Daewon Pharmaceutical (Korea) Plant-derived ingredients
Cavelin NewFace Laboratories (Korea) Deoxycholic acid
Michelangelo Renaissance srl Beauty Through Art (Italy) Phosphatidylcholine / deoxycholic acid
Contour injection SMIL DIET (Spain) Plant-derived ingredients
BNLSneo GRAND M & C (Korea) Plant-derived ingredient, deoxycholic acid
MITI HANS PHARMA (Korea) Phosphatidylcholine / deoxycholic acid

The main components of lipolytic injections are divided into three parts:

  • Deoxycholic acid (DOC)

It is the main component of lipolytic injection called "Kaibella", which is not used in Japan, and has the effect of destroying the cell membrane of adipocytes and reducing adipocytes, which is approved by the US FDA (US Food and Drug Administration) . When destroying the cell membrane, it has the disadvantage of causing inflammation at the injection site .

      • Phosphatidylcholine (PPC)

Unlike deoxycholic acid, it is not an ingredient whose efficacy has been approved by the FDA or other public institutions, but it has been shown to reduce subcutaneous fat in numerous clinical data. Although the specific mechanism that leads to the decrease of fat cells has not been elucidated, it is a component that has the disadvantage of causing inflammation at the injection site like deoxycholic acid.

      • Ingredients derived from plants (walnuts, seaweed, etc.)

It is a component of a drug that appeared after deoxycholic acid and phosphatidylcholine, and it is said that extracts extracted from plants such as walnuts and seaweed can be expected to be effective in reducing subcutaneous fat . Although there is no official approval for plant-derived ingredients, clinical data have confirmed a reduction in subcutaneous fat, and compared to drugs containing deoxycholic acid or phosphatidylcholine as the main components, after injection. It tends to be less prone to inflammation .


It is a drug whose main component is extracted from soybeans and whose safety is approved by KFDA (Ministry of Food and Drug Safety) . The active ingredient that is expected to act on fat cells is glycerophosphocholine (GPC), which is also contained in human breast milk . Glycerophosphocholine used in alfocholine is produced from lecithin, one of the lipids in soybeans.

Since it is not a drug based on deoxycholic acid or phosphatidylcholine, it is said that swelling and pain are less likely to occur after injection.


Deoxycholic acid, which acts directly on adipocytes, is the active ingredient, but the addition of artichoke extract, which has the effect of improving lymphatic flow and blood flow, causes swelling compared to conventional lipolytic injections containing deoxycholic acid. It is a drug developed to reduce the amount .

In addition, since artichoke extract also has a function of promoting metabolism, it can be expected to have an effect of facilitating the excretion of fat cells destroyed by deoxycholic acid. In addition to deoxycholic acid and artichoke extract, it also contains L-carnitine, which is a type of amino acid mainly contained in meat, and L-carnitine has a function of promoting energy conversion of fat when exercising. It is an ingredient that is made.


Deoxycholic acid and phosphatidylcholine are active ingredients . In addition, it contains L-carnitine, which is a type of amino acid, caffeine, which has vasodilatory and diuretic effects, and α-lipoic acid, which has antioxidant effects.

L-carnitine promotes the energy consumption of triglycerides released from destroyed fat cells, and caffeine, which has a diuretic effect, helps the destroyed fat cells to be excreted as urine by metabolism. It is an ingredient. Since α-lipoic acid has an effect of increasing metabolism in addition to an antioxidant effect, it can be expected to promote the excretion of destroyed fat.

Contour injection

Saponin, α-linolenic acid, Hibamata component, and tyrosine, which are plant-derived (medical herb) extracts, are active ingredients. Not only does it aim to reduce fat at the injection site, but it also contains ingredients that can be expected to be firming .

Drugs containing medical herbs as the main component, such as contour injection, are said to have a milder effect on reducing fat than drugs containing deoxycholic acid or phosphatidylcholine as the main components. On the other hand, it is less likely to cause pain and swelling after injection, so it tends to be used for lipolytic injection into the face .

BNLS neo

BNLS neo, the third generation of the series developed after the first BNLS and BNLS Version 2, is a combination of deoxycholic acid and BNLS, which is mainly composed of conventional medical herbs . It is a drug that is said to have a stronger fat-reducing effect due to the addition of deoxycholic acid, which has been recognized by the FDA as having a fat-reducing effect.

Among the fat dissolving injections currently performed in Japan, it is considered to be a drug that does not cause pain and swelling after injection, and many medical institutions use it as a fat dissolving injection to the face .