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Difference between the effect of Hague therapy that leads lost hair to regeneration and hair grow...



Difference between the effect of Hague therapy that leads lost hair to regeneration and hair growth and other thinning hair treatments

There are various treatments and treatments for thinning hair, such as increasing the amount of hair by attaching artificial hair to the remaining hair, taking finasteride, which is an internal medicine to prevent hair loss, and applying minoxidil to promote hair growth. There is a way.

As for hair growth, the artificial hair that is woven will float together as the hair grows, so it is necessary to perform maintenance once or twice a month, and each remaining hair will be burdened and it will be easier to pull out. Risk must also be considered.

Finasteride, an internal medicine that prevents hair loss, which is used in the treatment of androgenetic alopecia (AGA), and minoxidil external medicine, which promotes blood circulation to prevent hair loss and promotes hair growth, are effective in treating thinning hair. It is effective only with hair and can be said to be a protective treatment.

Hague therapy is a hair regrowth treatment developed based on regenerative medicine. It has a fundamental difference in action and effect from other hair growth treatments and hair loss prevention treatments, and is a treatment method that leads to regrowth of lost hair .

With regard to women's thinning hair, treatment options for women's thinning hair were limited because treatment with finasteride is contraindicated for those who are pregnant, may become pregnant, or breastfeeding. However, Hague therapy can also be expected to be effective as a treatment for thinning hair in women .

Understanding the mechanism of hair growth in Hague therapy and the differences from other hair thinning treatments, and knowing the number of effective treatments and the treatment methods that are more effective when used in combination is a satisfactory improvement in hair thinning. It leads to the effect .

Features of Hague therapy that leads to hair regeneration

HARG therapy is an acronym for "Hair Re-generative theraphy" and is a hair growth and hair growth therapy that is approved only by medical institutions . It is a regenerative medicine that is injected into the scalp and works on the inactive hair papilla cells, hair matrix cells, and surrounding hair follicle stem cells to promote hair growth .

The drugs used in Hague therapy have already been proven in Europe, the United States, South Korea, Japan, etc., and their hair growth and hair growth effects and safety have been established, and not only for men's thinning hair, but also for women's thinning hair. It is also an effective treatment method.

Normal hair cycle and thin hair cycle

There are various causes of thinning hair, such as the effects of male hormones, genetic factors, poor blood circulation due to stress, and disorder of lifestyle, but in any case, the function of cells that produce hair is reduced and the hair cycle (hair cycle) is shortened. Disturbance causes symptoms of thinning hair .

Each body hair has a growth period and lifespan, and in the case of hair, it is generally considered that the normal lifespan is about 2 to 6 years, and the hair cycle of growth period, catagen period, and telogen period is repeated. ..

Hair is formed by the proliferation, differentiation, and keratinization of hair matrix cells. It occupies 85 to 90% of the hair on the head and lasts for 2 to 6 years (catagen), 2 to 4 months. Hair cycle consisting of telogen, which lasts for a long time, repeats growth and regression throughout life

Source: Research trends in androgenetic alopecia treatment

1. Growth period

  • The period during which the hair continues to grow by supplying nutrients from the dermal papilla, which works to maintain the normal hair cycle in the hair root, to the hair matrix cells, which work to create hair.
  • Usually 2 to 6 years for men and 4 to 7 years for women
  • During the growth period, even if the hair comes off, new hair is immediately generated from the root and grows.

2. Regression period

  • The cell division of hair matrix cells gradually weakens, and the hair that grows becomes thinner and weaker.
  • Normal regression period is about 2-4 weeks

3. Rest period

  • Hair matrix cells are excreted from the pores to the outside of the body, and at the same time, the hair also falls off.
  • After that, it takes 2 to 3 months for new hair matrix cells to start activity, but it may be in a semi-permanent dormant state without activity.

Hair usually repeats a cycle of transitioning to the growth phase again after going through the growth phase, catagen phase, and telogen phase, but the symptom of thinning hair is that the hair cycle cycle is disturbed and the growth phase is shortened or the telogen phase is It manifests itself in prolonged or semi-permanent hibernation .

Hague therapy leads to hair regrowth by returning the disorder of the hair cycle that causes thinning hair to the normal cycle.

Even in areas where the hair has become thin, the cells themselves may actually be alive, just because the cells are in a long telogen phase due to the disorder of the hair cycle. If the Hague Cocktail can be injected into the scalp to activate cells that are in a semi-permanent telogen phase and restore the original hair cycle, hair regrowth can be expected .

However, if the hair is completely lost and the scalp is hardened, the cells often do not regenerate even if the Hague cocktail is injected, so even if the hair is grown, the area where the hair is present is the target of treatment. I will. Symptoms of thinning hair progress over time, so it is important to take radical treatment and effective measures at an early stage.

Those who are suitable for Hague therapy

  • Men who are worried about the thinness of the hair on the forehead and the crown (male pattern baldness: AGA)
  • A woman with a wide range of hair loss and thinning, centered on the parting of the hair (female alopecia)
  • Alopecia areata
  • Alopecia caused by stress and lifestyle
  • Those who did not get sufficient effect from treatment with finasteride or minoxidil
  • Those who wish to have further hair growth and hair growth effects in combination with finasteride and minoxidil

Hague therapy that has two effects, hair growth and hair growth

Hague therapy has two functions: a hair growth effect that promotes hair growth and a hair growth effect that grows thick and strong hair .

Hair growth effect of Hague therapy

Hague therapy involves lysing a frozen powder of proteins (cytokines) containing more than 150 types of growth factors extracted from adipose stem cells, and injecting the drug into the scalp to inject the drug into the hair follicles and hair that have lost their activity. It stimulates the mother cells and surrounding hair follicle stem cells to promote hair growth .

In 2018, the drug was renewed, and it became more specialized for hair by containing more exosomes and proteins, which are signal transmitters that play an important role in hair growth activity, than conventional products.

Stem cells are cells that can form and grow tissues and organs by changing (differentiating) into various cells, and due to their nature, in regenerative medicine aimed at recovering lost organs and functions of the body. It is attracting a great deal of attention as a central player.

In Hague therapy, cytokines and exosome signals, which are abundant in freeze-dried protein powder, are transmitted to cells related to hair, so that telogen cells shift to the growth phase again, and the cells in the growth phase Further activate the activities of.

The drug injected into the scalp not only acts as a growth factor contained in the powder, but also acts on the hair follicle stem cells in the back of the pores, so that the hair follicle stem cells secrete the growth factors themselves and stimulate the hair matrix cells. Continue. The hair growth effect lasts for a long time due to the two-step action of the growth factor contained in the powder and the growth factor produced by stimulating the hair follicle stem cells at the injection site .

Hair thinning treatment using finasteride or topical minoxidil becomes ineffective and returns to the original state if the treatment is stopped, whereas Hague therapy also has a hair-growth effect that grows grown hair into strong and thick hair. Therefore, it can be expected that the improved condition will be maintained even if the treatment is stopped.

Hair growth effect of Hague therapy

The second function of Hague therapy is the hair growth effect that grows the grown hair into strong and thick hair . In Hague therapy for hair growth, a protein containing more than 150 types of growth factors extracted from adipose stem cells is injected into the scalp.

PDGF, which is one of the growth factors contained in protein powder, has a function of maintaining the growth period of hair, and by recovering the shortened growth period, the period of sufficient hair growth is extended. It will be secured.

Effective number and duration of Hague therapy / pain of treatment

Effective number and duration of treatment of Hague therapy

It is said that it is desirable to continue the treatment about 6 times every other month in order to restore the disorder of the hair cycle (hair cycle) to the normal hair growth and hair growth effect of Hague therapy.

Generally, 6 to 9 times is treated as one course, and if thinning hair is a concern, the Hague cocktail is reinjected once every few months to half a year.

Time required for Hague therapy

The treatment time of Hague therapy varies depending on the range of the treatment site, but the injection itself is about 20 to 30 minutes, and 40 minutes to 1 hour in total including disinfection and anesthesia before the treatment and waiting time after the treatment. It is about .

Types of Hague Cocktail treatments and pain during treatment

Papure method using a syringe

The papule method is a method of injecting a Hague cocktail into the scalp in small amounts with a syringe , which is the most popular injection method in Hague therapy. Human skin has a three-layer structure consisting of the epidermis layer, dermis layer, and subcutaneous tissue from the outside. It is a method of injecting Hague cocktail between the epidermis and dermis to facilitate the penetration of the active ingredient.

You may feel some pain because you use an injection needle, but you can minimize the pain by using cooling anesthesia, spray anesthesia, or local anesthesia .

Non-needle Hague osmosis injection method with Medjet that suppresses pain

The Medjet is an injector that sprays the Hague cocktail into the skin through a 0.03 mm hole at the tip under the pressure of carbon dioxide injection. It is said that the pain is greatly reduced compared to the injection method using an injection needle , and anesthesia is not required . This method is suitable for those who are not good at injections and those who are not good at pain.

Effective thinning hair treatment and home care when used in combination with Hague therapy

Hague therapy has the effect of " growing " thinning hair and making the grown hair "thick and long", but it cannot prevent hair loss, so it is also a treatment to prevent the hair that has grown up from coming off. It is recommended to do it at the same time .

Effective combination treatment for androgenetic alopecia (AGA)

Androgenetic alopecia (AGA) is a common hair loss symptom in men that begins after puberty and progresses gradually. There are types that recede from the hairline of the forehead, types that thin the hair on the crown, and types that progress at the same time. Hair loss generally occurs mainly due to the effects of heredity and male hormones .

In androgenetic alopecia (AGA), "testosterone", which is a type of androgen, is changed to the bad androgen "DHT (dihydrotestosterone)" by the reductase "5α-reductase (5α-reductase)" in the body. It is caused by binding to the hormone receptor "androgen receptor".

DHT (dihydrotestosterone) bound to the androgen receptor has the effect of stimulating growth factors for body hair such as beards to grow thicker hair, but for hair such as the frontal region and crown. It has the function of suppressing the division of hair matrix cells and shortening the growth phase in the hair cycle.

A normal hair cycle takes about 1,000 to 2,000 days to complete one cycle, but if the hair cycle is disturbed by the onset of AGA, the growth period of the hair cycle will be extremely shortened to about 100 days.

The treatment of androgenetic alopecia (AGA) is an "aggressive treatment" that works on the hair matrix cells to activate hair growth like Hague therapy, and at the same time, a "defensive treatment" that protects the hair matrix cells from the attack of male hormones. It can be said that the synergistic effect is enhanced by using "" together .

Oral finasteride to prevent hair loss

Finasteride inhibits the action of type II 5α-reductase, which is abundant in hair papilla cells in the frontal region and parietal region, and suppresses the production of DHT (dihydrotestosterone), which is the cause of AGA. It can stop the progression of pattern baldness (AGA) .

In addition, finasteride is an ingredient that is indicated only for men by the Ministry of Health, Labor and Welfare, and caution is advised that it should not be used by women and children.

References: About the warning about PROPECIA (male pattern baldness drug): Ministry of Health, Labor and Welfare

Oral administration of dutasteride to prevent hair loss

Dutasteride finasteride Similarly, a Ministry of Health approved male pattern baldness (AGA) therapeutic agents for finasteride the can appeal only type II 5α reductase, dutasteride type I 5α reductase abundant in sebaceous glands , Inhibits the action of both type II 5α-reductase . In addition, it is said that the ability to inhibit the action of type II 5α-reductase is stronger than that of finasteride.

Minoxidil topical drug that promotes blood circulation and promotes hair growth

Minoxidil was originally a drug with a vasodilatory effect and was used as an ingredient in internal medicine for the treatment of hypertension, but it was later developed as an ingredient in topical hair growth agents due to the presence of hirsutism in patients undergoing treatment. Was promoted, and a hair restorer containing minoxidil was approved as a drug. It can be expected to promote blood circulation, prevent hair loss, and promote thick and long hair growth .

Effective combination treatment for female thinning hair (female alopecia)

Most men's hair loss is androgenetic alopecia (AGA), but women's hair loss has different causes and symptoms than men's hair loss. Female thinning hair is characterized by diffuse (widespread symptom) hair loss, which thins the entire head, and is not partial hair loss such as hairline or crown like male AGA. Therefore, it is said that the diagnosis is difficult.

It is known that most of the thinning hair in women has a decrease in hair density mainly in the center of the head, and histologically, the proportion of resting hair in the thinning hair part increases with the shrinkage of some hair follicles. It is called female pattern hair loss (FPHL) to distinguish it from androgenetic alopecia (AGA), which is widely recognized for thinning hair. In AGA, the hairline gradually recedes from the frontal region to the crown as it progresses, whereas in FPHL, the hairline in the frontal region is maintained and the hair density in the center of the head is diffuse. It is rare that the thinning hair area spreads over the entire head.

Source : Women's thinning hair and adenosine's improving effect

Since there are various causes such as hormonal imbalance and stress, it is collectively called female alopecia.

Oral finasteride, which is effective in treating androgenetic alopecia (AGA), is said to cause genital abnormalities in cases where the foetation is boys when taken by pregnant women. In principle, it is not administered.

Oral supplements that can be expected to improve scalp environment and improve thinning hair by distributing nutrition to the scalp, and topical minoxidil drugs that promote blood circulation to prevent hair loss and promote the growth of hair grown by Hague therapy. Combined use is recommended.

What you need to know when receiving treatment for Hague therapy

Precautions before treatment of Hague therapy

  • Avoid perms and coloring from 1 week before the start of treatment
  • Hague therapy repeats the procedure every other month, so consult a medical institution for perms and coloring during the treatment period.
  • Remove hair styling products before treatment

Precautions after treatment with Hague therapy

  • Refrain from washing your hair on the day of treatment (you can wash your hair as usual from the second day onwards)
  • Do not strongly stimulate the treated area with nails or brushes for about 3 days
  • Refrain from strenuous exercise for 1-2 days after receiving treatment
  • Refrain from perming and coloring for one week before and after the procedure
  • Cut more than 3 days after the procedure
  • Hair styling products can be used from the day after receiving treatment

Downtime risk of Hague therapy

In Hague therapy, intradermal injection is generally performed using an injection needle, so some blood may bleed, redness, or swelling may occur at the injection site of the drug, but within hours to days. It will settle down .

Internal bleeding may occur in rare cases when the procedure is performed using an injection needle, but it will subside in about 1 week to 10 days.

Hague therapy is a treatment method using unapproved products that have not been approved by the Ministry of Health, Labor and Welfare.
Acquisition route: The acquisition route is personal import by the doctor of each medical institution.
Drugs that should be noted in personal imports (Ministry of Health, Labor and Welfare page)
Approval in Japan: There is no product that has the same ingredients and actions for the purpose of thinning hair treatment and has been approved in Japan.
Information on safety in other countries: No serious side effects or complications of Hague therapy have been reported in other countries.

Those who cannot receive Hague therapy

Those who have trouble with the scalp

If you have itching, eczema, or swelling on your scalp, if you have hypersensitivity, or if you have just received another treatment / treatment, you may not be able to receive Hague therapy . Whether or not you can receive Hague therapy will be decided after the doctor examines the condition of your scalp.

When the pores of the scalp are closed due to thinning hair for many years and the hair roots are not clear

Hague therapy is a treatment that activates cells related to hair and promotes hair growth, so it is not effective for the scalp without cells . If the doctor examines the condition of the scalp and diagnoses that it is not effective, treatment may not be possible.

Hague therapy treatment flow and price quotes

Hague therapy treatment flow

(1) Counseling / examination

The doctor will first see you to see if your scalp is in good condition for Hague therapy.

(2) Disinfection / anesthesia

After recording the condition of the scalp and disinfecting the injection site, anesthesia is used to relieve pain during the procedure.

3) Treatment

The Hague cocktail is injected into the scalp by the papule method using a needle or the needle-free Medjet.

4) Explanation and prescription of precautions

After receiving an explanation about the precautions after treatment, if there is a medicine to be used in combination, have the medicine prescribed and the treatment is completed.

Hague therapy pricing

Number of times Fee
Once From 80,000 yen

The drug injected into the scalp in Hague therapy is an unapproved drug that has not been approved by the Ministry of Health, Labor and Welfare, and you will be responsible for all treatment costs for free medical treatment that is not covered by insurance.

In order to enhance the effect of Hague therapy on improving thinning hair, as aftercare after treatment, finasteride or topical minoxidil for men, and supplements and topical minoxidil that can be expected to improve the scalp environment for women. Many doctors recommend the combined use of medicines. Please contact each medical institution as there may be additional charges for prescribing drugs to be used in combination with Hague therapy.

To get a satisfying effect on thinning hair treatment

Hague therapy is said to be effective for those who have not seen much improvement in thinning hair due to treatments such as oral finasteride and topical minoxidil. However, the cause of thinning hair differs between men and women, and the degree of progression varies from person to person, so it is important to consult with a medical institution that has a track record of thinning hair treatment and receive thorough counseling .

A synergistic effect can be expected by using finasteride for men and oral supplements that regulate the scalp environment for women and hair thinning treatment such as topical minoxidil together with Hague therapy. If you are a doctor who has a track record of thinning hair treatment and has a large number of treatments, each person will propose a treatment that suits the cause and degree of progression of thinning hair .

(Updated January 2021)