Expected effects of BNLS injection of eyelids and what you need to know to avoid failure

BNLS is a fat-dissolving injection drug that has the effect of destroying fat cells at the injection site and leads to a decrease in subcutaneous fat, aiming for facial thinning and partial thinning that are difficult with exercise and dietary restrictions. Since inflammation and swelling are less likely to occur, there are cases where a drug that can be injected into the face, including the eyelids, can be expected to improve symptoms that make the eyelids look puffy or heavy.

However, depending on the cause of the eyelids appearing puffy or heavy, BNLS may not be effective in improving it .

Therefore, by knowing in what cases BNLS is effective, other treatments should be considered, or the specific effects, injection volume, risk, etc. of injecting BNLS into the eyelids. You can receive the treatment with confidence after knowing the characteristics of and solving your doubts .

Causes the eyelids feel swollen and heavy

There are three main causes for the eyelids to look puffy or heavy: cases with excess fat on the eyelids, cases with sagging eyelid skin, and ptosis with weak muscles that lift the eyelids ( This is due to a disease called swelling.

Symptom characteristics and treatment methods are different for each cause, and BNLS with lipolytic injection can be expected to improve when the excess fat under the skin makes the eyelids look puffy or heavy .

It is difficult to accurately identify and determine whether the cause of the eyelids appearing puffy or heavy is excess fat, sagging skin, or ptosis, so you need to be diagnosed by a doctor at a medical institution. ..

Before explaining the mechanism by which BNLS leads to the loss of fat in the eyelids, we will discuss the characteristics of each cause of the eyelids appearing puffy or heavy.

Cases caused by excess fat on the eyelids

There are two types of fat that cause swelling of the eyelids, "ROOF" and "orbital fat", and their locations are different.

• ROOF

Fat that exists under the skin from the eyelids to the area around the eyebrows, and is sandwiched between the orbicularis oculi muscle, which is the muscle used to open and close the eyelids, and the orbital septum that surrounds the orbital fat (cancer).

• Orbital fat

Fat that exists deeper than ROOF and covers the circumference of the eyeball, and acts like a cushion that protects the eyeball from external impact.

A large amount of ROOF, orbital fat, or both can cause the eyelids to appear swollen due to the thickness of the fat. The way ROOF and orbital fat are attached varies from person to person depending on the amount of fat on the face and the original constitution, but the Japanese and other Orientals tend to have more eyelid fat than Westerners, so they are swollen. It is said that it is easy to see.

Cases caused by sagging eyelid skin

Human skin has a three-layer structure of epidermis, dermis, and subcutaneous tissue (fat) from the outside. In the dermis layer, collagen and elastin, which is a fibrous protein that binds collagen to each other, are present, and hyaluronic acid, which is a jelly-like substance, fills the dermis with water.

When the dermis layer is damaged by aging or ultraviolet rays, hyaluronic acid, which stores water, collagen and elastin, which maintain the firmness and elasticity of the skin, deteriorate and decrease, causing sagging and wrinkles. Cutis laxa (cutis laxa) is a condition in which the skin of the eyelids sags due to aging, and the eyelids feel heavy or the visual field is obstructed .

If the cause of the heavy eyelid feel is cutis laxa, BNLS is not effective. The main treatments include "sub-eyebrow skin resection" or "upper eyelid excess skin resection" to remove the loose skin on the upper eyelid .

Both sub-eyebrow skin resection and upper eyelid excess skin resection can improve cutis laxa by stitching the incised skin after removing the excess skin. The former is different in that the skin is incised from the hairline under the eyebrows along the lower eyebrows, and the latter is incised along the double line, and the scars due to the operation are less noticeable in the upper eyelid excess skin resection. There is a tendency.

Cases caused by drooping eyelids

Ptosis is a condition in which the muscles that lift the eyelids and open the eyes are weak, causing the eyelids to drop and feel heavy or narrow the field of vision . Both eyelids may develop at the same time or only one, and may be congenital due to dysgenesis of the muscles that raise the eyelids, or acquired, mainly due to aging.

• Congenital ptosis

There is no causative disease, and it is mostly caused by hypoplasia of the levator palpebra muscle (cancer kenkyokin), which is the muscle that lifts the eyelids, and developmental abnormalities of the nerves that move the muscles.

• Acquired ptosis

Stimulations such as repeated rubbing of the eyelids accumulate with age, and the levator aponeurosis at the tip of the levator palpebra is cut or relaxed, causing the force to pull up the eyelids to be lost. Is almost

None of the ptosis is improved by BNLS. Surgical surgery and treatment that does not require a scalpel incision are performed according to the degree and cause of each individual's symptoms, such as the loss or weakness of the levator palpebra muscle, which is the muscle that opens the eyelids. .. The specific treatment method to be indicated is determined by a doctor's examination at a medical institution .

BNLS of lipolytic injection leading to adipocyte depletion

BNLS is one of the fat dissolving injection drugs that leads to the reduction of adipocytes by injection, and there are four types in the order of development: "first generation BNLS", "BNLS Version 2", "BNLS neo" and "BNLS Ultimate". is. BNLS is a drug whose main component is a plant-derived extract extracted from seaweed and walnuts, and currently only BNLS neo and BNLS Ultimate are produced .

Therefore, when BNLS is mentioned in the fat dissolving injection treatment menu at medical institutions, it basically means BNLS neo or BNLS Ultimate.

In addition to plant-derived extracts, BNLS neo and BNLS Ultimate each contain purines, amino acids, bile acids, etc. that are originally produced in the human body as active ingredients. Since each active ingredient has the function of destroying fat cells and promoting the metabolism of decomposed fat, it can lead to the reduction of subcutaneous fat present in various parts of the body such as the eyelids .

The ingredients contained in each of the BNLS series and the characteristics of each ingredient are as follows.

The active ingredient is added to BNLS with each version upgrade, and the lipolytic action is improved.

Ingredients included in all BNLS series

Adenosine triphosphate

• A component in which three phosphate molecules are bound to adenosine, which is formed by binding purine adenine, which is also present in the human body, and ribose, which is a type of sugar.
• By relaxing the smooth muscles of the muscles that regulate the thickness of blood vessels, it has the effect of expanding blood vessels to increase blood flow and promoting the formation of new blood vessels.

Adenosine triphosphate disodium

• A component in which two sodium molecules are bound to adenosine triphosphate
• It is a component that becomes an energy source when cells are active, and has the function of enhancing cell function and muscle activity.

Horse chestnut

• Extract from the seeds of deciduous horse chestnut (Aesculus hippocastanum)
• A component that has the effect of suppressing skin inflammation, calms redness of the skin, eliminates swelling, and gives elasticity to capillaries.

Tyrosine

• One of the amino acids that synthesizes the neurotransmitter catecholamine by reacting with intracellular enzymes
• Catecholamines stimulate and activate the "β3 adrenergic receptor," a protein required for intracellular signal transduction, which is present in the brain and fat cells.
• Activated β3 adrenergic receptors bind to the hormone noradrenaline secreted by the adrenal glands to break down triglycerides accumulated in adipocytes into free fatty acids used in the body's energy consumption such as exercise and basal metabolism. And promote the release into the blood

Rockweed extract

• An extract extracted from a brown alga called Hibamata, which is a type of seaweed, and contains minerals such as zinc and iodine, as well as collagen and amino acids.
• Iodine is a mineral required to produce the thyroid hormones "thyroxine" and "triiodothyronine" secreted from the thyroid gland into the blood.
• Thyroid hormone acts on all cells throughout the body to promote metabolism such as lipid and sugar metabolism and protein synthesis.

Persian gurumi

• A type of walnut native to eastern Europe, it contains α-linolenic acid, an essential fatty acid that humans cannot synthesize in the body, and vitamin E and arginine.
• Alpha-linolenic acid has the effect of synthesizing DHA and EPA, which are essential fatty acids that reduce LDL (bad) cholesterol in the blood, which causes arteriosclerosis.
• Since arginine, one of the amino acids, has a vasodilatory effect, it promotes blood circulation, increases blood flow, and promotes metabolism of waste products and decomposed fat accumulated in blood vessels.

Ingredients added from BNLS Version 2

Methylsilanol mannuronate

• A component consisting of arginic acid (mannuronic acid) contained in brown algae and methylsilanol, a compound containing silicon, which is a kind of mineral.
• It has the effect of promoting metabolism to the outside of the body by mainly decomposing neutral fat and emulsifying cholesterol (lipid) in blood, and can be expected to prevent fat adhesion on the blood vessel wall and prevent arteriosclerosis.

Methyl propanediol

• A type of fermented alcohol made from starch
• It has a moisturizing effect that prevents the decrease in water content of the stratum corneum, which is the uppermost layer of the skin, an antibacterial effect that enhances the permeability of active ingredients, an antibacterial effect that prevents the growth of bacteria, and an antiseptic effect that suppresses putrefaction due to the growth of microorganisms.

Ingredients added from BNLS neo

Deoxycholic acid

• One of the bile acids produced in the human body, a component whose double chin fat-dissolving effect has been recognized by the US FDA (US Food and Drug Administration), which is the Ministry of Health, Labor and Welfare in Japan.
• By lysing and destroying the cell membrane that covers the fat cells, it has the function of releasing the neutral fat stored in the cells and causing the fat cells to die.

Ingredients added from BNLS Ultimate

L-carnitine

• Amino acids that are originally present in the human body and are important for fat metabolism
• It has the role of carrying fat into the mitochondria of cells and burning it to produce energy.

artichoke

• An ingredient extracted from the perennial plant of the Asteraceae family, which is also edible, and has the function of promoting the secretion of bile that breaks down fat.
• The purifying action of blood leads to the reduction of bad cholesterol and triglyceride in the blood, and the diuretic action enhances the movement to expel necrotic fat cells from the body.

Catechin

• A type of polyphenol that enhances lipid metabolism and promotes fat burning, and is a bitter and astringent ingredient contained in tea and the like.
• It can also be expected to suppress the generation of active oxygen and prevent cell aging due to its strong antioxidant effect.

Coenzyme Q10

• One of the many coenzymes in mitochondria that is in the cells of the whole body and has the role of generating energy necessary for life activities.
• In addition to helping enzymes that work in digestion and metabolism, it is an ingredient that helps cell regeneration, activation, and prevention of aging through antioxidant effects.

Effect of BNLS injection on eyelid fat

There are various types of fat dissolving injection drugs other than BNLS. Drugs are roughly divided into two types, "drugs whose main component is plant extract" and "drugs whose main component is deoxycholic acid or phosphatidylcholine", and BNLS is classified into the former. ..

Deoxycholic acid is a component that has been recognized by the FDA as having a double-chin fat-dissolving effect, and phosphatidylcholine is a type of amino acid extracted from soybeans that enhances lipid metabolism and cholesterol in the blood. It is an ingredient that is said to have a function of promoting emulsification.

Drugs containing high concentrations of deoxycholic acid and phosphatidylcholine as the main components are good at decomposing fat, but as a side effect, large swelling due to inflammation may occur, so eyelids and other drugs Some items cannot be injected into the facial area.

BNLS neo and BNLS Ultimate each contain deoxycholic acid, but in addition to the fact that they contain deoxycholic acid in a concentration that does not easily cause side effects, the main component is a plant-extracted ingredient, so inflammation and swelling at the injection site are less likely to occur, and the eyelids. It is a drug that can be injected into the face including .

However, if the cause of the eyelids appearing puffy is other than fat, and there are also effects such as excess skin sagging, BNLS injection cannot be expected to make a significant change. Surgical treatment, which involves excision of the excess eyelid skin, may be required to be more effective.

BNLS can lead to a decrease in ROOF

If the thick ROOF of the fat that lies from the eyelids to the area around the eyebrows makes the eyelids look puffy, injections of BNLS neo or BNLS Ultimate are an option. The action of BNLS, which promotes the decomposition and metabolism of fat, leads to a decrease in ROOF, and it is possible to aim for a clean eyelid without swelling .

Although it can be removed surgically, ROOF is surgically because it is sandwiched between the orbicularis oculi muscle and the orbital septum, which are the muscles used to open and close the eyelids, and is sparsely distributed and widely distributed. It is said that it is difficult to remove it evenly by general surgery. If the removal is uneven, an "unplanned heavy eyelid line" may occur, in which a new eyelid line that has never existed before appears.

When surgically removing, the practitioner is required to perform a detailed procedure to remove the ROOF that is widely distributed while avoiding the small blood vessels under the skin, so the practitioner should cover the skin of the eyelids extensively to ensure a wide field of view. It is basically performed by a total incision procedure. Therefore, surgical removal of ROOF is a treatment with long downtime after surgery.

On the other hand, BNLS injections do not require long downtime because they do not require a scalpel incision in the skin . In addition, since the practitioner can make the drug work evenly by injecting the drug little by little into the site where ROOF is present, the treatment method with BNLS is selected when the eyelids look swollen due to ROOF. May be done.

BNLS injection into orbital fat is not recommended

Unlike ROOF, the orbital fat that lies deeper than the orbital septum and surrounds the eyeball is a flexible, massive adipose tissue. In order for the drug to act on the orbital fat, it must be injected accurately into the layer with the orbital fat through the orbicularis oculi muscle, ROOF, and orbital septum in the foreground.

In order to prevent the drug from acting on areas other than orbital fat, knowledge and skills that can accurately determine the thickness and depth of each tissue existing under the skin of the eyelid, such as the practitioner's familiarity with anatomy, are required. I will. In addition to the fact that orbital fat is a tissue near the eyeball, the drug is very rarely at risk of causing severe swelling due to severe inflammation as a side effect .

Therefore, it is said that lipolytic injections into orbital fat should not be taken not only by BNLS but also by medical institutions other than medical institutions where an ophthalmic emergency examination can be performed just in case. Some medical institutions allow injections into orbital fat, but in addition to making sure that an ophthalmic emergency consultation is available, you should fully understand the risks. ..

Estimated amount of BNLS injection into eyelids and number of treatments / progress

BNLS injection amount per treatment

BNLS neo and BNLS injection amount per treatment once against the eyelid of the Ultimate, you are both about 1cc is a guide. Not limited to the eyelids, BNLS drugs may cause swelling or inflammation at the treatment site as a side effect if injected in an amount that greatly exceeds the upper limit per injection.

If you wish to inject into areas other than the eyelids, the upper limit for each treatment is 20 cc for the face and 50 cc for the body. If you wish to perform treatments on multiple sites and the amount of subcutaneous fat you want to reduce is too large to exceed the upper limit of the amount that can be injected in each treatment, the treatment will be divided into multiple treatments.

In addition, genuine BNLS contains 10cc of undiluted solution in a glass bottle (vial bottle), and when actually performing the treatment, it is hoped that the undiluted solution will be sucked up from the bottle with a syringe in the amount used for each treatment. Inject into the area to be treated. To prevent the risk of infection, needles used in one procedure will not be reused in other procedures .

A small amount of anesthetic may be added to relieve pain

Many of the drugs for lipolytic injection such as BNLS are irritating to feel pain when injected subcutaneously, and when actually performing the procedure, a medical institution that injects a small amount of local anesthetic to the undiluted solution. There is also .

The ratio of the anesthetic to be added to the stock solution of BNLS to be used varies slightly depending on the medical institution, but approximately "stock solution 1cc: anesthetic 0.1cc" is standard, and it causes more pain than injecting the stock solution as it is. It becomes hard to feel .

Therefore, the BNLS treatment fee is generally determined based on the amount of undiluted solution used in the treatment, not the total amount of the drug actually injected. It is said that the effect of the treatment does not change depending on the presence or absence of an anesthetic, and some medical institutions indicate that the undiluted solution is injected as it is.

Number and course of BNLS injections on the eyelids

BNLS is mainly composed of plant-extracted ingredients, and compared to other drugs containing high concentrations of deoxycholic acid and phosphatidylcholine, it is less likely to cause inflammation and swelling, but has a mild effect of decomposing fat. It can be called a drug.

Therefore, when injecting into parts of the body that have a large amount of subcutaneous fat, such as the abdomen, back, and cellulite on the thighs, it tends to be more effective if the treatment is performed multiple times. However, the eyelids rarely get as much fat as the parts of the body, so a single treatment may be effective .

Swelling due to inflammation may occur for 2 to 3 days after receiving the treatment. In addition, fat dissolving injections such as BNLS do not cause a decrease in fat immediately after the procedure, and the effect gradually begins to appear over 3 to 7 days.

If one treatment does not work well, consult with your doctor about the amount of injection and consider whether to take a second treatment.

Risk downtime for BNLS injections on the eyelids

Risks and side effects of BNLS injection

When BNLS is injected using a needle, small blood vessels under the skin may be damaged by the needle, causing internal bleeding and redness on the surface of the skin . However, since countless platelets flowing in the blood stop bleeding immediately by the action of forming a blood clot, even if redness due to internal bleeding occurs, it tends to subside in about 1 week to 10 days.

Also, if you remove too much fat from your eyelids, there is a risk that your entire face will be out of balance and that there will be a difference between the left and right eyes . Therefore, please consult with your doctor at the counseling at a medical institution and carefully decide the injection amount while receiving advice. The main side effects include swelling, redness, pain, heat and tension due to inflammation.

Downtime due to BNLS injection

After injection of BNLS, inflammation may cause swelling or redness at the treatment site for 2 to 3 days . In addition, in rare cases, symptoms of numbness, itchiness, and urticaria at the treatment site may occur, but since BNLS is mainly composed of plant-extracted components, downtime compared to general lipolytic injection drugs. Because is short, these symptoms are said to subside in a few days.

In the unlikely event that the symptoms of numbness, itchiness, or urticaria continue for a long period of time, avoid self-care to prevent deterioration due to incorrect treatment, and consult the medical institution that received the treatment.

Major treatments other than BNLS that can be expected to reduce eyelid fat

Cell phase

Celluphase is one of the drugs for lipolytic injection. It is a drug that does not contain deoxycholic acid or phosphatidylcholine. It is mainly composed of plant extracts, so inflammation and swelling are unlikely to occur, and it is possible to inject it into the eyelids .

Artichoke, which promotes the secretion of bile that decomposes fat and the excretion of decomposed fat, the extract extracted from the hamamelis leaf of the deciduous tree, which mainly has anti-inflammatory effect, decomposes triglyceride and cholesterol in blood. It contains ingredients such as methylsilanol mannuronate, which has the function of promoting metabolism to the outside of the body by emulsifying.

The recommended amount of injection for the eyelids per treatment is about 1cc, and after receiving the treatment, you may feel slight swelling, redness, heat, pain, etc., but in most cases within 2 to 3 days. It is said that it will settle down.

It is the same as BNLS in that it contains plant extracts as its main component, but Cell Phase is a drug that does not contain deoxycholic acid, which has the effect of dissolving and destroying the cell membrane that covers fat cells. While it is less prone to inflammation and swelling, it promotes blood flow and lymphatic circulation to increase metabolism, aiming to eliminate decomposed fat, so its fat-reducing effect is mild .

Alfocholine

Alfocolin, which is one of the fat dissolving injections, is a drug whose main component is GPC (glycerophosphocholine ), which is an ingredient extracted from soybeans , and has been approved as a drug by the Ministry of Food and Drug Safety of Korea. GPC is a component produced from lecithin, which is one of the lipids of soybeans, and is also contained in human breast milk, etc., and is said to act on fat cells to dissolve them.

Since it is not a drug based on deoxycholic acid or phosphatidylcholine, it is said that inflammation, swelling and swelling are unlikely to occur, but those with soybean allergy symptoms cannot receive treatment . In addition, the injection amount for each eyelid is about 1cc as a guide, and after receiving the treatment, mild swelling, redness, heat, pain, etc. may appear as side effects for about 3 days.

On the other hand, BNLS does not contain soybean-derived ingredients and can be treated by people with soybean allergies, but the treatment fee per cc tends to be more reasonable for Alfocholine .

Upper eyelid defatting

Surgery to surgically remove excess fat from the eyelids is upper eyelid defatting surgery . Depending on whether the target to be removed is ROOF or orbital fat, some medical institutions call the surgical procedure to remove each independently as "ROOF removal" or "orbital fat removal". In addition, upper eyelid defatting may be performed at the same time as other surgery, such as double plastic surgery.

The basic content of performing upper eyelid defatting alone is to make an incision in the skin from the double line or the hairline under the eyebrows along the lower eyebrows, and in the case of ROOF, stretch it to the orbicularis oculi muscle and the orbital septum. Since it is attached, remove it by carefully peeling it off, or in the case of orbital fat, remove it by pulling out the orbital fat from the hole after making an incision in the orbital septum at the back.

If you have a lot of both ROOF and orbital fat, some medical institutions will show you to remove them at the same time. Also, when the eyelids look puffy due to excess skin in addition to fat, it is not uncommon for the skin to be removed at the same time as the fat is removed. After removing the fat (or fat and excess skin), the incision is sewn together to complete the surgery, and the patient will return to the hospital 5 to 7 days later to remove the thread.

For surgical scars, it is said that making an incision along a double line is less noticeable than making an incision along the line below the eyebrows from the hairline under the eyebrows. Downtime is about 1 to 2 weeks, during which time symptoms such as swelling and pain due to inflammation, internal bleeding, and redness tend to appear.

Since the downtime due to BNLS injection is about 2 to 3 days, upper eyelid defatting surgery involves a long downtime, but lipolytic injection such as BNLS is recommended for orbital fat. not. On the other hand, upper eyelid defatting is not limited to ROOF, but it can also remove orbital fat, and if there is excess skin, it can also be removed, so it is a treatment method that allows you to feel the change more reliably .

What you need to know when receiving an eyelid BNLS injection

Pain when injecting BNLS into the eyelids

BNLS injections can be used to relieve pain and receive treatment regardless of the site by using anesthesia cream or laughing anesthesia . In addition, most medical institutions use ultra-fine needles that are less likely to cause pain.

However, depending on the medical institution, the use of anesthesia is an option menu, and a separate fee may be charged. There are individual differences in the degree of pain, but since the eye area is a very delicate area where many capillaries and nerves are present and it is easy to feel irritation, those who are not good at pain should use anesthesia. please.

Precautions after receiving the treatment

Avoid touching the eyelids as much as possible on the day of the procedure

Bacteria that invade through the needle marks created by the procedure can cause pus and swelling. To prevent bacterial invasion from the needle marks, spend as little eyelid as possible on the day of the procedure. It is also recommended to refrain from swimming in the pool or swimming until the treatment area is calm and the needle marks are completely closed.

Refrain from promoting blood circulation on the day of treatment

Alcohol intake, bathing, and strenuous exercise have the function of dilating blood vessels and increasing blood flow, which may worsen internal bleeding and swelling, so please refrain from performing the procedure on the day of the procedure. In addition, showers are possible from the day of treatment, but it is recommended to refrain from using the sauna for 3 days after the treatment.

Makeup is possible from the day after receiving the treatment

When injecting BNLS into the eyelids, cleanse and wash the face before the procedure to remove makeup. Makeup is possible from the day after the treatment, so if you are interested, please bring sunglasses or a hat that can hide your eyes on the day of the treatment .

Those who cannot receive treatment

BNLS injections can be taken regardless of whether the eyelids are single or double, but those who fall under the following items cannot be treated.

• Those who have a history of allergies to the ingredients contained in BNLS
• Those with thyroid disease or immunodeficiency disease
• Those with microangiopathy or vascular insufficiency
• Pregnant and lactating
• Those who are undergoing anti-cancer drug treatment
• Those with unhealed trauma or illness on or around the eyelids
• Those who have taken alcohol on the day of the procedure
• Those who are judged to be maladaptive by other medical institutions undergoing treatment

In addition, some medical institutions do not perform treatments for people under the age of 18 or injections for the eyelids. Therefore, when considering a treatment, please check the homepage of each medical institution or the contact information for the corresponding age and site in advance.

Market price of treatment fee

Both BNLS neo and BNLS Ultimate, which are currently in production, are unapproved medicines by the Ministry of Health, Labor and Welfare, and they are free medical treatment for beauty purposes that are not covered by insurance, so you will be responsible for all costs. The market price per 1cc of injection is as follows.

Get a doctor's diagnosis and know your best treatment

For problems that make your eyelids look puffy or heavy, the appropriate treatment depends on the cause. To know exactly if the cause is excess fat, sagging skin, or ptosis, you need to be diagnosed by a doctor at a medical institution .

BNLS is a procedure that aims for partial thinning by acting on the subcutaneous fat present at the injection site, destroying fat cells and promoting metabolism. Therefore, if the cause of the eyelids appearing puffy or heavy is not due to excess fat, but due to sagging skin or ptosis, BNLS will not be effective.

Further, even fat was caused and thus excessively reduced because of the risks such as visible out of balance of the whole face, when considering BNLS injection eyelids, and how attached each and every different fats It is safe to receive the treatment under a doctor who knows the appropriate injection amount according to the amount .