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Effects and mechanisms of Exosome & Dermapen 4 to improve acne and sensitive skin

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Effects and mechanisms of Exosome & Dermapen 4 to improve acne and sensitive skin

Dermapen 4 is said to be able to penetrate the active ingredients of the drug deep into the skin by combining various drugs, and different effects can be obtained depending on the drug to be combined.

ASCE +, an exosome preparation derived from human adipose stem cells, can be combined with the treatment of Dermapen 4 to improve dullness, uneven color, open pores, dry skin, firmness and loose skin that has lost elasticity, as well as acne and atopic dermatitis. It is said that it can be expected to be effective in improving skin problems such as dermatitis .

In addition to the effects of the exosome preparation ASCE + and its mechanism, knowing who is suitable for ASCE + and the recommended number and frequency of treatments will lead to a satisfactory treatment effect.

Effect and mechanism of Dermapen 4 that promotes skin regeneration by natural healing power

Treatment with Dermapen 4 promotes the regeneration of skin cells by utilizing the "natural healing power" that is inherent in the human body to heal wounds and injuries .

By making a fine needle hole on the skin surface with a needle as fine as a hair, the natural healing power that tries to repair the needle hole works, and a growth factor that activates cell activity is secreted.

Growth factors are secreted by the natural healing power, and the turnover cycle, which is the metabolism of the skin, becomes active, which can be expected to improve the texture of the skin surface, open pores, and improve the roughness of the skin .

In addition, growth factors activate the functions of fibroblasts that produce collagen, elastin, and hyaluronic acid, which are involved in skin firmness, elasticity, and moisturization , leading to firmness, elasticity, and improvement of wrinkles and sagging . It is said to be effective.

Increased treatment effect by using the drug delivery effect of Dermapen 4

Human skin has a three-layer structure consisting of the epidermis layer, the dermis layer, and the subcutaneous tissue from the outside.

A barrier function works in the epidermis layer to prevent the invasion of bacteria from outside the body. While the barrier function blocks the invasion of foreign substances, active ingredients such as lotions and serums that are normally applied to the skin also stay on the surface of the epidermis layer and cannot penetrate deep into the skin.

However, by making a high-density needle hole from the epidermis layer to the dermis layer of the skin with Dermapen 4, the active ingredient of the drug that originally stays on the surface of the epidermis layer by just applying it firmly from the back of the epidermis layer to the dermis layer. since entering, you can expect more effective than as it is coated with a drug. The action of delivering the active ingredient to the necessary parts such as the inner part of the epidermis layer and the dermis layer is called "drug delivery" .

When various drugs are combined with Dermapen 4, the beauty ingredients of the drug penetrate evenly from the depth of the epidermis layer to the dermis layer through the fine needle holes made by Dermapen 4, so the effect of the drug can be further enhanced. ..

Exosome preparation ASCE + for improving rough skin, atopic dermatitis, acne, etc.

Exosomes are substances that play a role in transmitting information between cells in the human body.

The exosome moves between cells such as epidermal cells involved in turnover, which is the metabolism of the skin, and fibroblasts that produce collagen and elastin, and has an antioxidant effect that prevents skin cell regeneration and cell aging. It has the effect of helping to deliver the components of the drugs involved in the cells to the cells .

Exosomes are known to be secreted by every cell, and their properties depend on the type of cell that secretes the exosome.

Among them, exosomes secreted from "stem cells", which have the ability to divide to make the same cells as themselves and to differentiate into other types of cells, repair tissue functions such as promoting cell proliferation and wound healing. is that there is action to be, the use of exosomes derived from stem cells in the field of regenerative medicine has been focused.

In addition to exosomes, ASCE +, an exosome preparation derived from human adipose stem cells, contains various growth factors and peptides, coenzymes, amino acids, minerals, vitamins, and hyaluronic acid.

ASCE + is a mixture of two drugs before treatment

ASCE + uses up all 5cc per person in a fresh state immediately after mixing and dissolving two drugs , LYOPHILIZED EXOSOME and DILUENT .

Exosome powder that nourishes the skin and supports skin regeneration

The first drug, exosome powder, contains about 5 billion exosome particles . In addition to exosomes, it contains various active ingredients such as 5 types of growth factors, 6 types of peptides, 19 types of amino acids, 4 types of coenzymes, vitamins, and minerals.

These active ingredients are said to bring out even higher effects by binding to exosome microparticles and helping the exosomes deliver the components of the drug to cells.

Growth factors that promote skin cell regeneration

Growth factor is a general term for proteins that promote the proliferation and differentiation of specific cells in the human body (each cell acquires a function that matches its role), and helps the regeneration of damaged cells. It has the function of regenerating the skin.

The main types of growth factors are epidermal cell growth factor , which promotes skin renewal (turnover), collagen, elastin, hyaluronic acid, which are necessary to maintain skin elasticity, and detoxify active oxygen for skin aging. There are fibroblast growth factors that activate SOD (antioxidant) and so on.

Reactive oxygen is generated by itself when cells produce energy, and it is detoxified by simultaneously producing an enzyme called SOD, which has an antioxidant effect and cancels this. SOD production decreases with age. It is said that it decreases sharply from about 35 years old, and when the activity of cells decreases due to active oxygen, aging phenomena such as age spots and wrinkles begin to appear gradually.

Peptide that promotes proliferation and activity of skin cells

A protein in which 50 or more amino acids are bound is called a protein, but a protein in which 2 or more and less than 50 amino acids are bound is called a peptide. Peptides have the effect of promoting the proliferation and activity of skin cells . In addition, glutathione, a type of peptide, has an antioxidant effect that suppresses active oxygen that causes blemishes and wrinkles by aging cells.

Amino acids that support skin metabolism

Amino acids are said to be a material for the skin by themselves, and at the same time, they are a material for enzymes necessary for cell division, which promotes metabolism to create new cells and prevents skin aging .

Coenzyme that activates cell function

The human body is made up of about 60 trillion cells, and it is the mitochondria that produce energy in those cells. Coenzyme is a substance that exists in large quantities in the mitochondria and supports the production of energy, and has the function of activating cell functions . It also has an antioxidant effect that suppresses active oxygen that causes cells to age and cause spots and wrinkles .

Solution to dissolve exosome powder

The second drug acts as a solution that dissolves the exosome powder . It is a solution containing high-concentration high-molecular-weight hyaluronic acid, which is characterized by high water retention, 4 types of growth factors, 13 types of amino acids, and minerals.

It is said that it promotes the proliferation and differentiation of skin cells (acquisition of functions that suit each cell's role) , enhances the barrier function of the skin with high moisturizing power, and prepares the skin to be moist and moisturized. I will.

Synergistic effect of using Dermapen 4 and exosome preparation ASCE + together

By applying ASCE + at the same time as making a fine needle hole in the skin with Dermapen 4, the active ingredient can be delivered from the depths of the epidermis layer to the dermis layer, which normally does not penetrate by just applying it.

Activates turnover to repair and improve skin barrier function

ASCE + activates epidermal cells involved in turnover, which is the metabolism of the skin, in the epidermal layer, prevents the evaporation of water inside the skin, and has a barrier function to prevent the invasion of foreign substances (allergens, bacteria, etc.) from the outside. It is said that the action of repairing and improving leads to a smooth and healthy skin quality, and it can be expected to improve various skin problems such as sensitive skin, atopic dermatitis, dry skin, and repeated acne .

Improves dark spots and dullness caused by inflammatory pigmentation

When inflammation such as acne or insect bites occurs, or when it is strongly squeezed or rubbed, melanocytes (pigment cells) in the epidermis layer are stimulated to produce melanin, which is the cause of spots, but usually The turnover, which is the renewal of the skin, causes the melanin to come off along with the old keratin.

However, if the turnover is disturbed and melanin is not excreted normally and remains on the skin, inflammatory pigmentation will occur.

ASCE + works to normalize disturbed turnover , leading to improvement of age spots, dullness, color unevenness, etc. due to inflammatory pigmentation .

Activates fibroblasts to proliferate collagen and elastin

ASCE + activates fibroblasts that produce collagen and elastin in the dermis layer. By increasing the growth of collagen and elastin, it is said that it will lead to improvement of pore opening, firmness and lack of elasticity .

Clinical trials have shown that uptake of exosomes into fibroblasts increases collagen production by up to 6-fold, elastin levels by up to 3-fold, and cell proliferation by up to 80% .

Those who are suitable for Dermapen 4 + exosome preparation ASCE +

  • Those who want to improve acne skin
  • Those who want to relieve atopic dermatitis
  • Those who are worried about red face
  • Those who want to improve spots, dullness, and uneven color caused by inflammatory pigmentation
  • Those who are worried about roughness
  • Those who want to improve skin problems such as sensitive skin, dry skin, and rough skin
  • Those who are concerned about skin firmness and lack of elasticity
  • Those who are worried about wrinkles, sagging, and pore opening

Recommended frequency of Dermapen 4 + exosome preparation ASCE +

The combination of Dermapen 4 and ASCE + can be expected to be more effective because it activates the regeneration of skin cells and promotes the growth of collagen and elastin by repeating the procedure.

As for the number of treatments, it is said that the effect will be enhanced if the approach to the epidermis layer to the dermis layer is performed at least 3 times or 5 times .

As for the frequency, in order to enhance the short-term and medium-term effects of ASCE +, treatment is continued 3 times every 2 weeks at first, and after improvement, 4th and 5th treatments are received every other month to maintain the condition of the skin. After that, it is recommended to receive treatment every 6 months for maintenance .

Pain during treatment with Dermapen 4 + exosome preparation ASCE +

It is said that there is almost no pain because the anesthetic cream is applied before the procedure, but there are individual differences in how the pain is felt. It is said that you may feel a tingling sensation when you pierce the thin forehead or nose of the skin or when you pierce the needle deeply.

Downtime, risk, and precautions for Dermapen 4 + exosome preparation ASCE +

Downtime for Dermapen 4 + exosome formulation ASCE +

Redness may appear immediately after the procedure. Redness often subsides the next day and may last up to 3 days, but it can be covered with makeup .

Risk of Dermapen 4 + Exosome Preparation ASCE +

Dermapen 4 is a procedure to make a fine needle hole in the skin, so internal bleeding may occur in rare cases, but it is said that it will subside in about one week .

Precautions after treatment of Dermapen 4 + exosome preparation ASCE +

  • Do not get the treatment area wet for 6 hours (refrain from washing your face)
  • Refrain from regular makeup for 6 hours after the procedure (a foundation exclusively for Dermapen is acceptable)
  • Refrain from using basic cosmetics containing preservatives and alcohol on the day of treatment
  • Shower is possible from the day, bathing is possible from the next day
  • Avoid strenuous exercise on the day
  • Avoid irritation to the treatment site on the day and be careful not to rub
  • Be careful not to expose it to ultraviolet rays after the treatment
  • Avoid the sauna and pool for about a week
  • Refrain from stimulants such as alcohol and cigarettes for a few days
  • While the treatment area is reddish, moisturize it with preservatives, alcohol-free moisturizing cream, petrolatum, etc.

Those who cannot receive Dermapen 4 + exosome preparation ASCE + / Areas that cannot be treated

  • Pregnant / lactating
  • Those with diabetes and serious illness
  • Those with keloid constitution and dermatitis
  • People with collagen disease
  • Those with metal allergies
  • Those with infectious diseases
  • Those with herpes or bleeding disorders
  • Areas where severe acne is ongoing (possible if inflammation subsides)

In addition, if you are allergic to anesthetics, please consult with your doctor at the time of counseling / examination.

Dermapen 4 + exosome preparation ASCE + treatment flow

1) Doctor's consultation and counseling

The condition of the skin is checked by a medical examination, and the problem of the skin to be improved and whether the part is suitable for treatment are examined. If you have any concerns or doubts about the procedure, please check at the timing of counseling.

2) Face wash

To clean the treatment area, remove makeup and wash your face.

3) Apply anesthetic cream

Apply anesthetic cream and wait 20 to 30 minutes for the anesthesia to work.

4) Treatment

Wipe off the anesthetic cream and apply ASCE + while performing Dermapen 4.

5) Cooling

After the treatment, redness and burning may occur, so cool down with a cooling mask to soothe the skin.

6) Moisturizer / sunscreen

Apply moisturizing cream and sunscreen for Dermapen and you're done. If you wish, there is also a foundation exclusively for Dermapen, so please contact a medical institution.

Dermapen 4 + Exosome Preparation ASCE + Cost Market

The market price of Dermapen 4 and exosome preparation ASCE + is about 58,000 to 90,000 yen for one face . Some medical institutions offer initial discounts, and some have set fees such as 3-time and 5-time courses.

Option menu of Dermapen 4 other than exosome preparation ASCE +

Velvet skin that can be expected to have firm, glossy, and elastic skin effects

Velvet skin is a treatment menu that combines Dermapen 4 and collagen peel (massage peel), and was named because it leads to smooth and firm skin like velvet, which is a high-class woven fabric .

Collagen peel promotes collagen growth by applying a drug called "PRX-T33" that contains three components: high-concentration trichloroacetic acid, low-concentration hydrogen peroxide, and kojic acid, and makes the skin firm and elastic. It is a treatment that brings about .

In addition, kojic acid has the effect of suppressing the action of enzymes that make melanin, which is the cause of age spots, so it can be expected to have a whitening effect that leads to improvement of age spots and dullness .

Uber Peel, a peeling agent for Dermapen

Uber Peel is a peeling agent exclusively for Dermapen developed by Dermapen World, the developer of Dermapen 4.

Uber Peel has a peeling effect that restores the disorder of turnover, which is the metabolism of the skin, and is said to lead to improvement of rough skin such as clogged pores, open pores, darkening, dark spots and dullness, and acne .

Uber Peel contains not only a peeling effect, but also a whitening ingredient that is said to be effective for acne scars (pigmentation) after inflammation, and an ingredient that supports the regeneration of skin cells .

PRP (platelet rich plasma) that can be expected to have a skin rejuvenation effect using its own blood components

PRP (platelet-rich plasma) is obtained by extracting only platelet-rich plasma (plasma) from one's own blood using a medical machine .

By applying PRP while making fine needle holes in the skin with Dermapen 4, abundant growth factors contained in platelets permeate and activate fibroblasts that produce collagen and elastin that bring elasticity and elasticity to the skin. Let me do it.

It regenerates skin cells and promotes improvement of skin quality to make the skin firm and glossy, so it can be expected to be effective in improving fine wrinkles, sagging pores, roughness and acne scars, and uneven crater skin .

In addition, PRP (platelet rich plasma) is said to improve not only facial problems but also body problems such as stretch marks and flesh cracks.

Human-derived growth factors that improve fine wrinkles, pore openings, and dullness

Growth factors are a general term for proteins that promote the proliferation and differentiation of specific cells in the human body (each cell acquires a function that matches its role).

Growth factors also help the regeneration of damaged cells, so it is said that applying it to the skin with needle holes made with Dermapen 4 will further enhance the skin regeneration effect of Dermapen 4 .

One of the drugs whose main component is growth factor is the "BENEV Growth Factor" series.

MPF Rejuvenating Kit

It is a drug that contains abundant hyaluronic acid, peptides, and vitamins as growth factors. It improves fine wrinkles, maintains water with high-concentration hyaluronic acid, promotes cell regeneration and skin firmness .

MPF Complex Kit

It is a drug containing hyaluronic acid, vitamins, and evening primrose seed extract, which has antioxidant, anti-inflammatory, and whitening effects, as a growth factor. It improves skin color unevenness, pigmentation such as age spots and spots caused by ultraviolet rays , and leads to bright and soft skin.

Collagen booster (PCL) that promotes collagen production

Collagen booster is a treatment that promotes collagen production by combining Dermapen 4 and PCL (polycaprolactone).

PCL (polycaprolactone) is a component of meltable thread used in surgery. Since PCL (polycaprolactone) has the effect of promoting collagen production in the dermis layer, by infiltrating PCL (polycaprolactone) into the dermis layer with Dermapen 4, it promotes its own collagen production and makes the skin firm and elastic. It is supposed to lead .

PCL (polycaprolactone) is slowly absorbed into the body over a year, so it is said to have a long duration of effect .

How to choose a medical institution to receive Dermapen 4 + exosome preparation ASCE +

The combination of Dermapen 4 and exosome preparation ASCE + is also available for people with sensitive skin and atopic dermatitis, and can be expected to improve various skin problems such as dry skin, inflammatory pigmentation and acne.

Medical treatment that first consults with counseling and gives a convincing explanation as to whether your skin problems are likely to be improved with ASCE + and whether it is better to combine other option menus to achieve the desired effect. Choosing an institution will lead to a satisfactory treatment effect.

In addition, in the treatment using Dermapen 4, there is a risk of causing infectious diseases such as hepatitis B and C and AIDS due to blood infection if the medical equipment used is not hygienic. As a risk measure for infectious diseases, it is safe to choose a medical institution that you can trust in hygiene management, such as using disposable needles and attaching a special body cover .

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