Collagen production effect and duration of Dermapen 4 and PCL (collagen booster)

Dermapen 4 can enhance the effect of the active ingredient of the drug by treating it with a combination of various drugs, and different effects can be expected depending on the drug to be combined.

Among them, the treatment that combines PCL (polycaprolactone), which has the effect of promoting the production of collagen called "collagen booster", is effective for wrinkles and sagging by increasing the collagen that has the function of maintaining the firmness and elasticity of the skin. Can be expected.

Before receiving a treatment that combines Dermapen 4 and PCL, knowing the duration of the effect, the recommended number of treatments, downtime, precautions, etc. will lead to a satisfactory treatment effect.

Effect and mechanism of Dermapen 4 that regenerates skin with natural healing power

Dermapen 4 makes invisible fine needle holes on the surface of the skin and utilizes the "natural healing power" that is inherent in the human body to heal wounds and injuries by itself. It is a treatment that promotes the regeneration of.

By making a fine needle hole on the skin surface with a needle as fine as a hair, the natural healing power to repair the needle hole works, and a growth factor that activates cell activity such as cell division and cell repair is secreted. Will be done.

By activating the action of fibroblasts that produce collagen, elastin, and hyaluronic acid, which give the skin firmness and elasticity due to growth factors, it leads to improvement of wrinkles, sagging, and pore opening .

Furthermore, the activation of skin cells activates the skin turnover cycle, which can be expected to be effective in improving the texture of the skin .

Turnover is the metabolism of the skin, in which old skin cells are pushed by new skin cells born in the lower layers and rise to the surface of the skin, eventually becoming keratin and naturally peeling off, and the skin is reborn. That is.

If the turnover cycle is disturbed due to fatigue, stress, disordered eating habits, constipation, etc., the texture of the skin may be disturbed or the barrier function that protects the skin may deteriorate, causing skin problems such as rough skin, acne, and pimples. It is said that it will be.

Treatment effect enhanced by drug delivery action

Human skin has a three-layer structure consisting of the epidermis layer, dermis layer, and subcutaneous tissue from the outside, and the barrier function works on the surface of the epidermis layer. While the barrier function blocks the invasion of foreign substances such as bacteria, the active ingredients such as lotion and serum applied to the skin usually stay on the surface of the epidermis layer and cannot penetrate deeply.

Therefore, by making a high-density needle hole from the epidermis layer to the dermis layer of the skin with Dermapen 4 and applying the drug, the active ingredient of the drug that originally stays on the surface of the epidermis layer by just applying it is from the needle hole to the epidermis layer. -Since it penetrates firmly into the dermis layer, it can be expected to be more effective than applying the drug as it is. This action is called "drug delivery" .

PCL (polycaprolactone) that promotes its own collagen production

PCL is a component of meltable suture that does not require thread removal and is used in surgical operations such as cardiac surgery and plastic surgery, and is naturally decomposed and absorbed in the body. In the field of cosmetology, it is the same as the component of the meltable thread used in the thread lift for sagging treatment.

PCL that has penetrated under the skin has the effect of promoting the production of new collagen, and can be expected to improve the firmness, elasticity, and wrinkles of the skin that have been lost with age .

Synergistic effect of using Dermapen 4 and PCL together

When performing a combination of Dermapen 4 and PCL, use the PCL-based drug SOSUM PCL Solution. SOSUM PCL Solution has very small PCL particles, so when combined with Dermapen 4, it easily penetrates under the skin, and it is said that side effects such as swelling and inflammatory reaction (redness) can be minimized.

By applying SOSUM PCL Solution at the same time as making a needle hole with Dermapen 4, it is possible to deliver PCL, which is the active ingredient, to the dermis layer, which normally does not penetrate by just applying it.

In human skin, the dermis layer is dominated by the fibrous protein "collagen", which is filled with water, and the jelly-like substance "hyaluronic acid" fills the space between them. In addition, a fibrous protein called "elastin" bundles collagen that is layered in a mesh pattern, giving the skin firmness and elasticity.

Collagen plays an important role in maintaining the firmness and elasticity of the skin, but the amount of collagen produced peaks in the 20s and decreases with age, so if nothing is done, the skin will become firm and elastic. The elasticity is gradually lost, causing wrinkles and sagging.

PCL has a function called "collagen booster" that promotes the production of new collagen around the permeated subcutaneous skin, so by permeating PCL to the dermis layer with Dermapen 4, the decreasing collagen is increased and the skin becomes firm. It is said that the elasticity will return .

In addition, PCL particles have the effect of causing slight inflammation around the infiltrated site in the process of being absorbed into the body, and this inflammation stimulates the production of new collagen in the dermis layer. , You can expect improvement of skin firmness and elasticity over a long period of time . PCL is slowly absorbed by the body over a period of about 12 months.

The return of elasticity and elasticity creates moisture on the skin, smoothes the texture of the skin, and leads to improvement of thin and delicate under-eye and fine wrinkles on the eyes, fine wrinkles on the cheeks, and opening of pores .

Those who are suitable for Dermapen 4 + PCL

• Those who are concerned about skin firmness and lack of elasticity
• Those who are worried about wrinkles and sagging
• Those who are worried about fine wrinkles and sagging around the eyes and fine wrinkles on the lips
• Those who want to open pores and tighten slack pores
• Those who are worried about the roughness of the skin and want to smooth the texture of the skin
• Those who want to have a long-lasting natural skin-beautifying effect

Duration of effect of Dermapen 4 + PCL and recommended number of treatments

The combination of Dermapen 4 and PCL is a treatment that uses its own natural healing power to bring about firmness by increasing collagen, so the effect is said to appear little by little over a period of 1 to 2 weeks after the treatment .

The combination of Dermapen 4 and PCL takes an approach to the dermis layer three times every four weeks to form three layers of collagen , leading to more firm and elastic skin .

PCL is said to have a long-lasting effect because it is gradually decomposed over a period of about 12 months and absorbed into the body .

Pain during Dermapen 4 + PCL procedure

There is no strong pain because the treatment is performed after applying the anesthetic cream to the treatment site, but when you pierce a thin part of the skin such as the forehead or nose or a needle deeply, you may feel a slight tingling pain. It is said that you can put up with it.

Dermapen 4 + PCL downtime, risks and precautions

Dermapen 4 + PCL downtime

Redness and burning may appear immediately after the procedure, but it is said that it will subside in about 2 to 3 days . The redness of the face can be hidden with makeup from the next day.

Dermapen 4 + PCL risk

Dermapen 4 pierces the skin with a very fine needle, so internal bleeding may occur in rare cases, but it is said that it will subside in about a week .

Dermapen 4 is a procedure to make fine needle holes in the skin, so if the medical equipment used is not hygienic, there is a risk of causing infectious diseases such as hepatitis B and C and AIDS due to blood infection .

As a measure against the risk of infectious diseases, it is safe to choose a medical institution that you can trust in hygiene management, such as using disposable needles and firmly attaching a special body cover.

Precautions after Dermapen 4 + PCL treatment

• Do not get the treatment area wet for 6 hours (refrain from washing your face)
• Refrain from regular makeup for 6 hours after the procedure (a foundation exclusively for Dermapen is acceptable)
• Refrain from using basic cosmetics containing preservatives and alcohol on the day of treatment
• Shower is possible from the day, bathing is possible from the next day
• Avoid strenuous exercise on the day
• Avoid irritation to the treatment site on the day and avoid rubbing
• Be careful not to expose it to ultraviolet rays after the treatment
• Avoid the sauna and pool for about a week
• Refrain from stimulants such as alcohol and cigarettes for a few days
• Moisturize with preservatives, alcohol-free moisturizers and petrolatum, as the skin becomes temporarily delicate and easier to dry.

Those who cannot receive Dermapen 4 + PCL / Parts that cannot be treated

• Pregnant / lactating
• Those with diabetes and serious illness
• Those with keloid constitution and dermatitis
• People with collagen disease
• Those with metal allergies
• Those with infectious diseases
• Those with herpes or bleeding disorders
• Areas where severe acne is ongoing (possible if inflammation subsides)

In addition, if you have anesthesia allergy, please consult your doctor at the time of medical examination and counseling.

Dermapen 4 + PCL treatment flow

Dermapen 4 + PCL cost market

The market price for Dermapen 4 and PCL treatment is about 50,000 to 100,000 yen for one face . Some medical institutions offer initial discounts, and some have set fees such as 3-time and 5-time courses.

Dermapen 4 option menu other than PCL

Uber Peel, a peeling agent for Dermapen

Uber Peel is a peeling agent exclusively for Dermapen developed by Dermapen World, the developer of Dermapen 4.

Uber Peel has a peeling effect that restores the disorder of turnover, which is the metabolism of the skin, and is said to lead to improvement of rough skin such as pore clogging, pore opening / darkening, skin spots and dullness, and acne .

Uber peel contains not only a peeling effect, but also a whitening component that is said to be effective for acne scars (pigmentation) after inflammation, and a component that supports the regeneration of skin cells, promoting natural healing power and promoting skin skin. It is said to enhance the effect of Dermapen 4, which aims for reproduction .

Velvet skin that can be expected to have firm, glossy, and elastic skin effects

Velvet skin is a treatment menu that combines Dermapen 4 and collagen peel . It is called velvet skin because it leads to smooth and firm skin like velvet, which is a high-class woven fabric.

Collagen peel promotes collagen growth by applying a drug called "PRX-T33" that contains three components: high-concentration trichloroacetic acid, low-concentration hydrogen peroxide, and kojic acid, and makes the skin firm and glossy. It is said to bring a feeling .

Since kojic acid has the effect of suppressing the action of the enzyme that makes melanin, which is the cause of age spots, it can also be expected to have a whitening effect that leads to improvement of age spots and dullness .

Dry human amnion / chorion allogeneic implant that improves acne scars AmnioGenix

The human chorioamnionitis, a thin collagenous membrane derived from the placenta, is a highly elastic tissue that encloses the fetal growth and development in the maternal endometrium. Since it contains abundant growth factors, it has an excellent wound healing effect and promotes the regeneration of skin cells .

Growth factors are a general term for proteins that promote the proliferation and differentiation of specific cells in the human body (each cell acquires a function that matches its role).

Growth factors also help the regeneration of damaged cells and regenerate the skin, so it is said that applying it to the skin with needle holes made with Dermapen 4 will further enhance the skin regeneration effect of Dermapen 4. ..

AmnioGenix, a dry human amniotic membrane / chorion preparation, can be expected to be effective in treating acne scars, crater skin, and scars with conspicuous irregularities when used in combination with Dermapen 4 .

PRP (platelet rich plasma) that can be expected to have a skin rejuvenation effect using its own blood components

PRP (Platelet Rich Plasma) is made by collecting your own blood and extracting only the plasma containing a large amount of platelets from the blood with a medical centrifuge.

By applying PRP while making fine needle holes in the skin with Dermapen 4, abundant growth factors contained in platelets permeate and activate fibroblasts that produce collagen and elastin that bring elasticity and elasticity to the skin. Let me do it.

It regenerates the skin cells themselves and promotes the improvement of skin quality from the inside to firm and glossy skin, so not only facial problems such as fine wrinkles, sagging pores, rough skin and acne scars, and uneven crater skin, but also facial problems. It can be expected to improve body problems such as stretch marks and cracks .

Human adipose stem cell-derived exosome preparation ASCE + that improves atopic dermatitis and sensitive skin

Human adipose stem cell-derived exosome preparation ASCE + contains various growth factors, peptides, coenzymes, amino acids, minerals, vitamins, and hyaluronic acid, as well as exosomes that play a role in cell-to-cell communication.

The exosome moves between cells such as epidermal cells involved in skin renewal turnover and fibroblasts that produce collagen and elastin related to skin firmness and elasticity, and regenerates skin cells contained in ASCE +. It is said to deliver the components of drugs involved in such things to various cells.

The exosome preparation ASCE + also has the function of supporting the barrier function to prevent the invasion of foreign substances (allergens, bacteria, etc.) from the outside, and various foreign substances and irritation from the outside such as sensitive skin, atopic dermatitis, dry skin, and repeated acne. You can expect improvement of skin troubles caused by .

In addition, the exosome preparation ASCE + works to normalize disturbed turnover, resulting in pigmentation stains that remain after inflammation such as redness, rough skin, acne and insect bites, and after strong rubbing or squeezing. It leads to improvement of dullness and uneven color .

How to choose a medical institution to receive Dermapen 4 + PCL

A collagen booster that combines Dermapen 4 and PCL is a treatment that promotes its own collagen production, tightens open pores, and leads to firm and elastic skin.

In addition, Dermapen 4 has different effects by combining various drugs, so you can choose the option according to your own worries and wishes.

It is safe to consult with counseling first to see if your skin problems will improve with the collagen booster that combines Dermapen 4 and PCL, and then select a medical institution that will give you a convincing explanation and better suggestions .

In addition, in order to obtain the full effect of Dermapen 4, it is necessary to undergo the treatment under a doctor who is familiar with the different skin thickness and effective needle depth for each part of the face . ..

One option is to choose a medical institution that has a doctor who has received a direct lecture on the correct procedure from the training doctor of Dermapen World , the developer of Dermapen 4.