Dermapen 4 promotes skin renewal by utilizing the natural healing power inherent in the human body, and by combining various drugs, the active ingredient of the drug is delivered to the depths of the skin and absorbed. I can. The effect obtained depends on the drug to be combined.
The growth factor, which is combined as an option menu of Dermapen 4, supports the skin regeneration of Dermapen 4, proliferates and activates cells, promotes turnover, which is the metabolism of the skin, and improves the firmness and elasticity of the skin. It has the function of promoting the production of collagen, hyaluronic acid, and elastin that are retained .
One of the drugs whose main component is growth factor is the "BENEV Growth Factor" series .
Before receiving a treatment that combines Dermapen 4 and Beneb Growth Factor, you can receive the treatment with peace of mind by knowing the expected effects, the recommended number and frequency of treatments, downtime and precautions . ..
Table of contents
Dermapen 4 is a procedure in which the needle moves up and down at a high speed, which is said to be 120 times per second, to make invisible fine needle holes on the skin surface.
Treatment with Dermapen 4 utilizes the natural healing power of the human body, which is the ability to heal wounds and injuries on its own. By making a fine needle hole on the skin surface with a needle as fine as a hair, skin cells are reborn by the natural healing power that tries to repair the needle hole .
Growth factors that activate cell activity to heal needle holes are secreted , and the turnover cycle, which is the metabolism of the skin, becomes active, which makes the skin smoother and makes the skin rough, acne, and pimples. It leads to improvement of trouble .
In addition, it is said that the action of growth factors activates the action of fibroblasts that produce collagen, elastin, and hyaluronic acid that give the skin firmness and elasticity and retain water .
Dermapen 4 is equipped with a scar treatment mode (ST mode), which is a scar healing (hankonchiyu) mode that can make needle holes up to the deep layer of the skin (3.0 mm) , as a new function not found in conventional models . It has become possible to focus on the treatment of crater-like acne scars and scars .
In ST mode, it is necessary to move the needle not only vertically but also intentionally at an angle, so the procedure is usually performed by a doctor rather than a nurse.
Human skin has a three-layer structure consisting of the epidermis layer, dermis layer, and subcutaneous tissue from the outside, and on the surface of the epidermis layer, a barrier function that prevents the invasion of foreign substances from the outside and the evaporation of water in the body works inside. I am protecting.
While the barrier function of the epidermis layer blocks the invasion of foreign substances such as bacteria, the active ingredients such as lotion and serum applied to the skin usually stay on the surface of the epidermis layer and do not penetrate deeply. can not.
Therefore, by making a high-density needle hole from the epidermis layer to the dermis layer of the skin with Dermapen 4 and applying the drug, the active ingredient of the drug that originally stays on the surface of the epidermis layer by just applying it is from the needle hole to the epidermis layer. Since it penetrates firmly from the back of the skin to the dermis layer, it can be expected to be more effective than applying the drug as it is. This action is called "drug delivery" .
Growth factor is a general term for proteins that promote the proliferation and differentiation of specific cells in the human body (each cell acquires a function that matches its role), and helps the regeneration of damaged cells. It has the function of regenerating the skin .
It is also called a growth factor, cell growth factor, etc., and is called "Growth Factor" in English.
Growth factors are substances that control cell division that creates new cells. They are originally produced in the body, but they decrease with age and are said to decrease sharply after the age of 20.
The decrease in growth factors leads to the inactivation of cell division, which is thought to cause various skin aging phenomena such as wrinkles, sagging, and age spots.
The main types of growth factors are epithelial cell growth factor (EGF) , which promotes skin metabolism turnover in the epidermis layer, and fibroblasts, which promote the production of collagen, elastin, and hyaluronic acid in the dermis layer. These include fibroblast growth factor (FGF) .
When a drug containing growth factors as the main component is combined with the treatment of Dermapen 4, it is possible to supplement the growth factors that decrease with age and penetrate from the depths of the epidermis to the dermis layer, so the synergy between Dermapen 4 and growth factors It is said that the effect enhances the skin regeneration effect .
It activates the turnover, which is the rebirth of the skin, and smoothes the texture , leading to improvement of skin problems such as acne and pimples, and can be expected to improve crater-like acne scars and scars .
It is also said to promote the production of collagen, elastin, and hyaluronic acid, leading to firm and elastic skin, and improving wrinkles, sagging, and pore opening .
When performing treatment with a combination of Dermapen 4 and growth factors, there is the "BENEV Growth Factor" series as one of the drugs whose main component is growth factors, and the following two types of drug combinations can be selected. ..
Growth factor preparations from American pharmaceutical company BENEV are produced by Dr. Greg Magwire, a former professor who was conducting research related to regenerative medicine at the University of California and is still a leader in regenerative medicine and tissue regeneration. It is a highly safe drug that is involved in development and has been approved for manufacturing by the US FDA, which is the Ministry of Health, Labor and Welfare of Japan.
The MPF Rejuvenating Kit is a set containing 10 vials of a drug called "Rejuvenating Complex" designed to repair wrinkles and lack of elasticity due to aging and UV rays (4 ml per vial).
It supports the regeneration of skin cells, restores firmness to the skin, and aims to improve wrinkles and open pores .
The MPF Complex Kit is a drug called "Brightening Complex" designed to improve skin pigmentation and whitening effect, in addition to the 5 vials of "Rejuvenating Complex" mentioned above. Vials are included in the set (1 vial 4 ml).
It leads to firm and elastic skin, and aims to improve uneven color, dullness, and age spots .
|Main ingredients||Rejuvenating Complex||Brightening Complex|
|Purified epithelial cell growth factor||○||○|
|Purified fibroblast growth factor||○||○|
|Vitamins B2, B3, B5, B6||○||○|
|Vitamin H (biotin)||○||○|
|Human fibroblast conditioned medium||○|
|Evening Primrose Seed Extract||○|
Epithelial cell growth factor promotes the growth of cells (epithelial cells) such as skin and mucous membranes in the epidermis layer and promotes turnover, which is the metabolism of the skin, so it improves the texture of the skin and leads to improvement of acne and rough skin. I will.
Epithelial cell growth factor has the effect of promoting wound healing that heals wounds, so acne scars and scars can also be improved .
In addition, the activation of turnover makes it easier to excrete the melanin pigment that causes age spots from the body, so it can be expected to improve age spots and dullness .
Fibroblast growth factor activates fibroblasts that stimulate the production of collagen, elastin, and hyaluronic acid in the dermis layer to repair skin tissue and lead to firm and elastic skin .
Fibroblast growth factor also has the function of activating SOD (antioxidant), which detoxifies active oxygen and prevents skin aging .
Reactive oxygen is generated by itself when cells produce energy, and it is detoxified by simultaneously producing an enzyme called SOD, which has an antioxidant effect and cancels this.
SOD production decreases with age. It is said that it decreases sharply from about 35 years old, and when the activity of cells decreases due to active oxygen, aging phenomena such as age spots and wrinkles begin to appear gradually.
Hyaluronic acid, which maintains the firmness, elasticity, and moisture of the skin, is a viscoelastic substance that originally exists in the human body. It has extremely high water retention capacity and viscosity, and it is said that 1 g of hyaluronic acid has a water retention capacity of 2 liters to 6 liters. I will.
By blending a high concentration of hyaluronic acid, it maintains the moisture in the wound area damaged by Dermapen 4 and supports the regeneration of firm and elastic skin .
Vitamin C is a nutrient needed to produce collagen, which gives the skin elasticity. Incorporating Vitamin C supports collagen production, aiming for firm and elastic skin .
Vitamin C also has an antioxidant effect that removes active oxygen, which is said to cause skin aging such as age spots and wrinkles .
Vitamin E, also called a rejuvenating vitamin, is one of the vitamins with a strong antioxidant effect that detoxifies active oxygen, which is said to cause cells to age and cause spots and wrinkles .
The treatment of Dermapen 4 causes the rebirth of skin cells and removes the active oxygen generated by the activation of cell division.
It is a vitamin that is mainly useful for the regeneration, growth promotion, and health maintenance of cells in the skin and mucous membranes, and it works to assist enzymes that work when cells convert sugars, lipids, and proteins into energy.
It is a vitamin that is deeply involved in maintaining the health of the skin and mucous membranes, and has the function of preventing skin inflammation . It is said that if it is insufficient, skin symptoms such as atopic dermatitis and hair loss will appear.
Its main function is blood coagulation (hemostatic effect) . Vitamin K is essential for the production of components that clot the blood and stop bleeding when it bleeds. It also activates the proteins needed for bone formation.
The conditioned medium (Junkabaichi) is a medium in which specific cells are once cultured and then the cells are removed. When cells are cultured in the medium, they secrete trophic factors that can provide nutritional support to other cells .
Human fibroblast conditioned medium is a medium obtained by culturing human-derived fibroblasts and contains nutritional factors secreted by fibroblasts.
A tripeptide is a compound composed of three types of amino acids, and its properties and functions are determined by the type and sequence order of the amino acids.
Tripeptide-1 Copper is a combination of tripeptide-1 and copper. It has an antioxidant effect that causes skin cells to age and cause spots and wrinkles, and promotes the production of collagen and elastin in the skin. It is said to have the effect of providing elasticity and elasticity to prevent the occurrence of wrinkles and improving the unevenness of acne scars .
Palmitoyl tetrapeptide-7 is a reaction product of four amino acid peptides and palmitic acid. It has the effect of suppressing the increase in IL-6 (interleukin), a substance that causes skin inflammation . It is also said to improve wrinkles and sagging.
Evening primrose seed extract has a high antioxidant effect that removes active oxygen that causes skin aging, and is said to prevent blemishes and wrinkles .
In addition, it inhibits the activity of the enzyme (tyrosinase) that works when the melanin pigment that causes age spots is made and suppresses the production of melanin pigment, so it can be expected to have a preventive effect on age spots and dullness .
It is said that you may feel the effect even once, but there are individual differences in how you feel the effect and how long it lasts.
The required number of times varies depending on the condition before the treatment, age, skin type, and target condition, but if repeated treatment is performed 5 to 6 times every 4 to 6 weeks, the effect will last for a longer period of time. It is said that it can be done.
It is said that you will not feel strong pain because the treatment is performed after applying the anesthetic cream, but it is said that you will feel a slight tingling pain when you pierce a thin part of the skin such as the forehead or nose . ..
Redness may appear immediately after the procedure. It is often pulled the next day, but since the depth of the needle is adjusted according to the skin trouble, redness may continue for 2 to 3 days depending on the treatment content.
Even if redness appears, you can hide it with makeup from the next day . The needle holes made by Dermapen 4 are fine and less burdensome to the skin, and the skin recovers quickly after the treatment, so it is said that you can receive regular treatment without disturbing your daily life.
Since Dermapen 4 is a needle-sticking procedure, it may cause internal bleeding in rare cases, but it is said that it will subside in about a week .
In order to avoid the risk of infectious diseases, Dermapen 4 has developed a special cover to be attached to the main body of the device, and the tip with the needle is disposable .
Those who meet the following items may not be able to receive the treatment, so please consult your doctor in advance.
1) Doctor's consultation and counseling
We will check the condition of the skin by medical examination and counseling by a doctor, and examine the skin troubles you want to improve and whether the part is suitable for treatment. If you have any concerns or doubts about the procedure, please check with your doctor at the time of consultation and counseling.
2) Face wash
To clean the treatment area, remove makeup and wash your face.
3) Apply anesthetic cream
Apply anesthetic cream and wait 20 to 30 minutes for the anesthesia to work.
Wipe off the anesthetic cream and apply Dermapen 4 while applying the Beneb Growth Factor series of drugs.
After the treatment, redness and burning may occur, so cool down with a cooling mask to soothe the skin.
6) Moisturizer / sunscreen
Apply sunscreen for moisturizing cream and dermapen and finish. If you wish, there is also a foundation exclusively for Dermapen, so please contact a medical institution.
The market price of Dermapen 4 and Beneb Growth Factor is about 30,000 to 50,000 yen for one face . Some medical institutions offer initial discounts, and some have set fees such as 3-time and 5-time courses.
"AmnioGenix" , a drug mainly composed of dried human amniotic membrane and chorion, can be expected to be effective in treating acne scars, crater skin, and scars with conspicuous irregularities when used in combination with Dermapen 4 .
The human chorioamnionitis, a thin collagenous membrane derived from the placenta, is a highly elastic tissue that encloses the fetal growth and development in the maternal endometrium. Since it contains abundant growth factors, it has an excellent wound healing effect and promotes the regeneration of skin cells.
The procedure that promotes collagen production by combining Dermapen 4 and PCL (polycaprolactone) is also called a collagen booster.
PCL (polycaprolactone) is a component of meltable thread used in surgery, etc., and is also used in thread lift, which is a lift-up procedure using thread in cosmetology.
Since PCL polycaprolactone has the effect of promoting collagen production in the dermis layer, by infiltrating PCL (polycaprolactone) into the dermis layer with Dermapen 4, it promotes its own collagen production, and wrinkles are less noticeable and elastic. It is said to lead to the skin .
Polynucleotide, the active ingredient of rejuran, is a molecule extracted from salmon DNA, which is not approved in Japan, but has been approved by the Korean Ministry of Health, Labor and Welfare, KFDA, and has been proven to be safe. ..
Rejuran stimulates fibroblasts in the dermis layer and promotes the production of collagen and elastin, which helps restore elasticity, elasticity, and flexibility, so it can improve wrinkles, sagging, and open pores .
Rejuran is said to create the thickness of the epidermis as well as the dermis by regenerating skin cells. When the epidermis layer regains its normal thickness, the barrier function of the skin is strengthened and the moisturizing power is improved. Rejuran is said to reduce the secretion of excess sebum, restore the balance of fat and water, and improve the texture of the skin .
Stem cell culture supernatant (stem sap) is a supernatant produced when human stem cells are cultivated and proliferated. It is obtained by extracting and purifying a culture solution containing abundant growth factors secreted by stem cells .
Growth factors have the function of activating cell division in the skin, normalizing the turnover, which is the metabolism of the skin, and leading to smooth skin .
In addition, since the production of collagen, elastin, and hyaluronic acid, which are related to elasticity and elasticity, is promoted, it can be expected to improve the elasticity, tighten open pores, and improve wrinkles .
Placenta means "placenta", and there are multiple types such as horse-derived and pig-derived. Human placenta used in aesthetic medicine is placenta extracted from human placenta.
Contains abundant active ingredients such as vitamin C, which suppresses the production of melanin pigment that causes age spots, removes active oxygen that causes skin aging such as wrinkles, and amino acids that keep skin moisturized. It can be expected to have effects such as promoting collagen production .
In addition, placenta contains many growth factors. The action of growth factors activates turnover, which is the metabolism of the skin, making it easier to excrete the melanin pigment that causes age spots from the body .
Dermapen 4 can damage the skin, prolong downtime and reduce the effectiveness of the procedure if not performed properly.
Having a doctor who is familiar with the different skin thickness and effective needle depth in each part of the face will help you get the full benefits of Dermapen 4.
It is safe to choose a medical institution that has a doctor who has experience in technical training by actively participating in study sessions and lectures to deepen your knowledge about how to handle Dermapen 4 correctly .
In addition, Dermapen 4 is a treatment that can be expected to have various effects depending on the combination of drugs.
Beneb Growth Factor is a drug that contains growth factors as the main component, but there are other drugs that contain growth factors as the main component, and because the components other than growth factors are different and the amount is different, it is possible to use your own skin. You need to choose the drug that suits your worries and wishes.
Before receiving the procedure, it is recommended that you receive sufficient counseling and receive treatment at a reliable medical institution to see if the Dermapen 4 and Beneb Growth Factor treatments are likely to improve your skin problems. I will.