Rejuran injection is a cosmetological treatment that injects a preparation containing a polynucleotide (PN) of DNA extracted from salmon as the main component, and the polynucleotide has the effect of promoting the increase of proteins that play a role in skin firmness and elasticity. , Helps regenerate damaged skin, etc.
There are four types of rejuran injection preparations, and each preparation has different characteristics, such as those that aim to improve wrinkles around the eyes and those that can be expected to have the effect of smoothing the texture of the skin. Also, depending on the skin problem you want to improve, treatments other than rejuran injection may be suitable.
Therefore, when considering rejuran injection, it is necessary to know the different actions and characteristics of each preparation and the differences from other treatments, as well as the risks of the treatment and the recommended number of treatments to obtain sufficient effects in advance. It is important to understand.
Table of contents
A preparation containing a salmon-derived DNA called polynucleotide (PN) , which has the effects of helping the regeneration of skin damaged by stimuli such as ultraviolet rays and promoting the increase of growth factors, which are proteins that activate cell activity. "Rejuran injection" is a procedure to inject subcutaneously .
Rejuran injection preparations contain polynucleotides extracted from salmon as the main component, so they are sometimes called "salmon injections" depending on the medical institution.
In addition, although the formulation for rejuran injection has not been approved in Japan, it has been approved by KFDA in South Korea, which is the Ministry of Health, Labor and Welfare of Japan, and polynucleotides have been approved as a component of pharmaceutical products in Europe for the treatment of burns and wounds. It is being used.
DNA (deoxyribonucleic acid), which also exists in humans, is located in the center (nucleus) of cells throughout the body and holds the information necessary to make all the parts that make up the body, such as the skin, organs, and organs. , Also called a blueprint for living organisms.
Nucleotides are the basis for making DNA, which has a spiral structure. Nucleotides are made by combining "deoxyribose," which is a type of sugar, with "phosphoric acid," which is a type of acid, and "base," which is an alkaline substance. Point to. A polynucleotide is a chain of multiple nucleotides arranged in a row, and two of these polynucleotides are spirally gathered in DNA.
Polynucleotides bind to a type of skin protein called "A2 purinergic receptor" that is involved in skin cell proliferation and differentiation (each cell acquires a function that matches its role) and wound healing. It has a stimulating effect, which promotes the increase of growth factors, calms inflammation, and helps the regeneration of damaged skin.
Fibroblasts (senigasaibo), which produce collagen and elastin, which are proteins that play a role in skin firmness and elasticity, are activated by increasing growth factors, leading to improvement in skin firmness and elasticity. Therefore, you can expect the effect of making wrinkles and open pores less noticeable .
In addition, the skin has a three-layer structure of epidermis, dermis, and subcutaneous tissue from the outside, and the epidermis has a barrier function to prevent the invasion of bacteria from outside the body, and the dermis has collagen and elastin. There are substances that support the firmness and elasticity of the skin and the fibroblasts that produce them, and underneath it is composed mainly of the subcutaneous tissue, which is fat.
The function of polynucleotides to regenerate skin cells makes it possible to create the thickness of not only the dermis layer but also the epidermis layer. By regaining the normal thickness of the epidermis layer, the barrier function of the skin is enhanced, and the effect of improving the texture of the skin by improving the moisturizing power and making the dullness less noticeable can be expected.
Salmon has a large amount of DNA contained in each cell and has a structure (base) similar to that of humans, and the extracted polynucleotide has a risk of causing side effects or being eliminated as a foreign substance when taken into the human body. Is low .
For this reason, preparations containing high concentrations of polynucleotides extracted from salmon have come to be used in cosmetological injections.
The rejuran injection formulation is a series of four types, and the main treatment applications are divided according to the hardness of the formulation adjusted by processing each and the active ingredients contained in addition to the polynucleotide. When actually performing the treatment, the preparation that suits the problem that you want to improve is selected by the diagnosis by the doctor.
|Type of formulation||Hardness of formulation||Main target of adaptation|
|Rejuran||Moderate hardness||Wrinkles, pores, firmness, and skin texture on the face and body (back of hands, neck, etc.)|
|Rejuran i||soft||Small wrinkles at the corners of the eyes, bears under the eyes|
|Rejuran s||hard||Skin dents (scars) and scars caused by acne scars|
|Rejuran HB||Moderate hardness||Wrinkles, pores, firmness, skin texture, moisturizing of face and body|
Each rejuran injection formulation has a different package color: normal rejuran is black, rejuran i is white, rejuran s is blue, and rejuran HB is purplish red. The characteristics and expected effects of each formulation are as follows.
Ordinary rejuran is a formulation with moderate hardness, and tends to be suitable for those who are concerned about wrinkles, pore openings, firmness, and skin texture that occur mainly on the face and back of the hands . By activating fibroblasts and regenerating skin cells by promoting the increase of growth factors of polynucleotides, it leads to improvement of wrinkles and pore opening that become noticeable with aging.
It corresponds to various parts, and basically anywhere there is a problem such as wrinkles and pore opening caused by the loss of skin thickness due to the accumulation of stimuli such as aging and ultraviolet rays. It is possible to inject.
The softest formulation in the Rejuran series is Rejuran i, which is suitable for people who are concerned about fine wrinkles and bears that occur mainly around the eyes . Fibroblasts in the dermis layer are stimulated by polynucleotides to promote the production of collagen and elastin, which maintain the firmness and elasticity of the skin, which is expected to have the effect of making fine wrinkles less noticeable.
In addition, by injecting into the area under the eyes, it is possible to improve the bear caused by the decrease in skin thickness by increasing collagen and elastin and creating the thickness of the dermis layer and epidermis layer.
Rejuran s is the hardest formulation in the four types of Rejuran series, and has the property of being highly viscous and difficult to spread around the injection site. It has the effect of supplementing the volume of the skin at the injection site, but it is basically not used as a contouring treatment for the purpose of raising the height of the nose and adjusting the face line.
In addition to helping the regeneration of damaged skin by polynucleotides, it is a hard preparation that has a high effect of compensating for dents on the skin, so it occurs after the trauma and inflamed acne have healed. You can expect the effect of making dents and scars inconspicuous .
In addition to polynucleotides that promote the increase of growth factors and regenerate skin cells, a preparation containing hyaluronic acid, which is a viscoelastic substance originally present in the human body, and lidocaine, which is a component of anesthesia, is Rejuran HB ( Lidocaine Hydro Booster).
Hyaluronic acid is a substance that is said to have a water retention capacity of about 2 liters to 6 liters per gram, and by incorporating it, it can be expected to have the effect of keeping the skin moisturized . In addition, lidocaine, which temporarily paralyzes nerve transmission, is characterized by reducing irritation when injecting the drug .
In the rejuran injection, the preparation is injected little by little from the epidermis to the dermis layer where wrinkles and pores are worrisome, but there are two treatment methods: manual work by the practitioner and a method using an injection machine. The feature of manual injection is that the depth and density of injection of the preparation can be finely adjusted, and the time required for injection by machine is shorter than that of manual injection .
In the case of manual treatment, a fine injection needle with a diameter of 0.26 mm (33 G) attached to the package of the preparation, a finer injection needle with a diameter of 0.18 mm (34 G), and a needle with a rounded tip from the side There is a tendency to use a cannula that has a structure that allows the drug to come out and can adjust the direction of injection of the drug by rotating the needle under the skin.
Machine injections are generally made with an automatic syringe that has 3 to 5 needles at the tip and a structure that allows the formulation to be injected in a planar and uniform manner. By injecting the preparation by applying the tip with multiple needles to the treatment site, it is possible to inject multiple points per shot, so it is possible to perform a wide range of treatment in a shorter time than manual work. ..
In addition, if you wish to perform a treatment on a wide area such as the entire face, you may perform the treatment by hand on small areas such as the outer corners of the eyes, and by injection on a wide area such as around the cheeks, in combination.
The thinner the needle, the less pain you will feel when inserting it subcutaneously, but it will interfere with the injection of highly viscous preparations, so a certain thickness is required. Depending on the medical institution, anesthesia may be used when performing the procedure, so if you are concerned about pain or are not good at it, please check the homepage of each medical institution or the contact information.
Rejuran injection is a formulation that can be injected regardless of the site. Each package contains 2cc (2ml), and when performing the procedure, only the amount actually injected is sucked up with a syringe.
The amount of injection varies depending on the range of treatment, but when injecting into the entire face, about 2cc is a guide , and it is common to inject about 0.2cc in small amounts per single part such as the forehead and mouth. It is said that. Also, instead of injecting 0.2cc into a single site as it is, inject 0.2cc into a single site in smaller amounts and inject a small amount into multiple sites.
For local treatments such as wrinkles on the outer corners of the eyes using Rejuran i and skin dents treated with Rejuran s, 0.2cc to 1.0cc is a guideline for the injection amount .
The fee for the procedure is not the fee per package of opened Rejuran, but the amount of the actually injected preparation (cc) and the optional injection needle prepared separately for each anesthesia and medical institution. In most cases, that fee will be charged.
Since Lijuran injection is a procedure in which the preparation is injected into multiple subcutaneous sites, fine needle holes (Hariana) and small bulges on the surface of the skin appear in several places immediately after the procedure . It will be less noticeable in a day or two . Makeup is possible immediately after receiving the treatment, so if you are interested, you can make it inconspicuous by applying make-up.
In rare cases, redness at the injection site or damage to small blood vessels under the skin during the procedure may cause internal bleeding, but even if it does occur, it usually subsides within a few days to a week.
|Immediately after the procedure (on the day)||Fine needle holes and small bulges appear in several places on the treatment site.|
|1-2 days later||Needle holes and small bulges caused by the procedure begin to become inconspicuous|
|3 days to 1 week later||In case of rare redness or internal bleeding, these symptoms will subside.|
|2-4 weeks later||A guideline for gradually feeling the effect|
Rejuran injection has no immediate effect, which is effective immediately after receiving the treatment. Due to the increase of growth factors by polynucleotides and the action of promoting the regeneration of skin cells, there is a tendency for the skin to gradually become firmer and more elastic after 2 to 4 weeks, and to feel natural changes such as improved makeup. is.
The duration of the effect is about 3 months as a guide , and the effect obtained by one treatment is mild, but you can expect a higher effect by receiving multiple treatments on a regular basis.
In order to get the full effect of Lijuran injection, it is recommended to have a total of 4 treatments at intervals of 2 to 3 weeks . In addition, it is said that there is no upper limit to the number of times you can receive treatment, and by receiving regular treatment such as once every six months, you can aim for youthful skin with firmness and elasticity and wrinkles and pores are less noticeable. I can do it.
If you want an injection that can help make deep wrinkles less noticeable with a single treatment, other treatments such as Lady Esse injection or hyaluronic acid injection, which have the effect of supplementing the volume of the skin, may be suitable.
Immediately after receiving the treatment, fine needle holes may be created by inserting the injection needle, and the skin surface may swell slightly depending on the preparation, but it will become less noticeable over a period of 1 to 2 days . In addition, there is a risk of internal bleeding due to damage to small blood vessels under the skin and bleeding, but it tends to subside within a few days after the bleeding is naturally blocked by a blood clot .
Polynucleotides extracted from salmon have a low risk of causing a foreign body reaction, but in rare cases allergic reactions can occur . Other possible risks and side effects include temporary redness and mild swelling and pain at the site of treatment.
In addition, if a drug is accidentally injected into a blood vessel, there is a risk of impaired blood flow, so it is important to select a doctor who has a large number of injections and is experienced.
There are various types of injections other than rejuran injection that improve wrinkles and pore openings that become more noticeable with age. Injections tend to be less burdensome to the body and have shorter downtime than surgical treatments that involve incisions in the skin, but the characteristics such as active ingredients and actions differ depending on each formulation as follows.
|Hyaluronic acid injection||Hyaluronic acid, a viscoelastic substance, is infused with a preparation in which a cross-linking agent is added to adjust the hardness to supplement the volume of the skin.|
|Lady Esse injection||Supplements skin volume by injecting a formulation of solid calcium hydroxyapatite, which is the main component of bones and teeth, in the form of particles and wrapped in a sticky gel.|
|Elance||Promote collagen production by injecting a preparation containing a thickener into fine particles of bioabsorbable soluble suture components|
|Snekos||Injecting a preparation consisting of hyaluronic acid that does not contain chemical substances such as cross-linking agents and 6 kinds of amino acids leads to firm and elastic skin|
|Baby collagen injection||Aiming to improve skin quality by injecting a preparation containing type III collagen that promotes skin tissue regeneration and activating skin cells|
Hyaluronic acid is a jelly-like substance that originally exists in the human body and has the role of storing water in the dermis layer in the skin. Many hyaluronic acid injections used in aesthetic medicine contain a cross-linking agent that connects the hyaluronic acid molecules, which makes it possible to adjust the hardness of the preparation.
Hyaluronic acid injection has viscoelasticity and has the effect of supplementing the volume of the skin at the injection site, so it has the effect of making dents (wrinkles) on the skin such as nasolabial folds and gorgolines less noticeable, and of tear bags. You can expect the formation. Injectants, whose hardness has been increased by a cross-linking agent, are used in contouring procedures to raise the height of the nose and adjust the face line.
Like the rejuran injection, it has the effect of making wrinkles less noticeable, but it does not promote the increase of growth factors or help the regeneration of skin cells . In addition, rejuran injection is basically not used in contouring procedures. Treatment for shallow wrinkles such as fine wrinkles may be effective with one treatment, and the duration is 6 to 24 months as a guide.
Lady Esse injection is a procedure to inject a preparation called calcium hydroxyapatite (CaHA), which consists of calcium and phosphate ions, which is mainly composed of solids, which are the main components of bones and teeth . When actually performing the treatment, a formulation in which calcium hydroxyapatite is made into fine particles and wrapped in a sticky gel is used.
It is harder than hyaluronic acid injectables and has the property of retaining its shape when injected, so it tends to be used in treatments that sharpen the nose and chin and raise the height . The duration is about 10 to 18 months, and Lady Esse has the effect of stimulating fibroblasts, and the increase in collagen can be expected to bring about the firmness and elasticity of the skin.
Rejuran injection can be expected to improve shallow wrinkles such as fine wrinkles around the eyes, but Lady Esse is a hard preparation and there is a risk of unevenness when injected into the shallow layer of the skin, so to the shallow layer of the skin Treatment is not suitable . Therefore, unlike Lijuran injection, it is suitable for deep wrinkles such as Golgo line, nasolabial fold, and marionette line.
The effect lasts for a long time of up to 3 years, and the main component is polycaprolactone, which is also a component of meltable sutures used in surgery, processed into fine particles, and protects polycaprolactone to maintain its viscosity. It is a preparation containing carboxymethyl cellulose that has a function.
Polycaprolactone, the main component of Elance, has a function called "collagen booster" that promotes the production of collagen around the injected site, so it is possible to regain the firmness and elasticity of the skin that decreases with age. By improving the elasticity and elasticity, you can expect the effect of making fine wrinkles on the cheeks and outer corners of the eyes less noticeable.
In addition, by injecting the preparation pinpointly, the action of supplementing the volume of the skin works, leading to improvement of deep wrinkles such as nasolabial folds and aiming for contour shaping.
Snecos is a preparation containing hyaluronic acid, which does not contain chemical substances such as cross-linking agents, and 6 types of amino acids. Hyaluronic acid, which moisturizes the skin and stores water, and amino acids, which promote the production of collagen and elastin in the skin, can be expected to have the effect of restoring the firmness and elasticity of the skin and improving the quality of the skin .
In addition, Snecos is a patented formulation of a specific amino acid and hyaluronic acid that stimulates the production of collagen and elastin. By regaining the firmness and elasticity of the skin that has been lost due to aging and stimuli such as ultraviolet rays, it can be expected to have the effect of making fine wrinkles around the eyes and mouth, pore openings, and uneven skin less noticeable.
It can be said that the expected effect is a preparation with characteristics similar to those of rejuran injection, but since rejuran injection is a preparation containing salmon-derived DNA as the main component, those with fish / roe allergies cannot receive treatment. ..
Baby collagen injection is a procedure that allows you to take in type III collagen, which has the role of giving flexibility to the skin, from the outside . Type III collagen is a collagen that decreases at a high rate with age, and it is said that it almost disappears from the body by the end of the growth period.
Type III collagen has the function of promoting the regeneration of damaged skin tissue, and it is said that the more abundant the skin is, the more fluffy and elastic it becomes. By supplementing type III collagen with baby collagen injection and increasing the elasticity of the skin, effects such as improvement of fine wrinkles and contraction of pores can be expected.
Rejuran injections are considered to have a low risk of being recognized as foreign substances and causing an elimination reaction when taken into the body, but in rare cases allergic reactions may occur. On the other hand, baby collagen injections are made from fibroblasts extracted and cultured from human placenta, so the risk of allergies is extremely low .
If you touch the treatment site more than necessary immediately after receiving the rejuran injection, there is a risk that bacteria will invade through the needle hole created by the injection needle and cause an infection, so be careful not to touch it as much as possible for several days after the treatment. Please spend time. Actions that promote blood circulation, such as drinking alcohol or strenuous exercise, can cause internal bleeding and swelling, so it is recommended to refrain from doing so for about two days.
Makeup, face washing and bathing can be done from the day of the treatment unless strong stimulation is given to the treatment site, but massage should be refrained from for about a week. In addition, it is necessary to have a doctor diagnose at a medical institution as to whether or not other treatments can be performed on the treatment site .
Since Lijuran's preparation is a drug that has not been approved in Japan, please understand that there are the following points to be noted, and carefully explain the risks of treatment at a medical institution before considering it.
|Rejuran is an unapproved drug in Japan.|
| Drug acquisition route: The acquisition route is individual import from the manufacturer by the doctor of each medical institution.|
Drugs to be aware of when importing personally (Ministry of Health, Labor and Welfare page)
|Whether or not it is approved in Japan: There is no other drug that has the same ingredients and actions as Rejuran and has been approved in Japan.|
|Information on safety in other countries: Approved by KFDA in South Korea. Risks and side effects that can occur with Rejuran injection include transient small bulges, internal bleeding, redness, swelling, pain, allergies, and infections that occur at the treatment site.|
(1) Medical examination and counseling
After completing the questionnaire, the doctor will give you a medical examination and counseling to tell you what you want to improve, such as wrinkles and pores, and receive a diagnosis as to whether or not Rejuran injection is suitable. You will also receive explanations on the risks and precautions of the procedure, so if you have any concerns or doubts, please consult at this time.
(2) Face washing / anesthesia
After washing your face to clean the area, wait for a while with surface anesthesia such as anesthesia cream or tape to relieve the pain of using a needle.
(3) Injection of rejuran preparation
A small amount of Lijuran's preparation is manually or machine-injected into the desired treatment area. The approximate time required for the procedure, excluding anesthesia, is about 20 to 40 minutes. In addition, the injection method differs depending on the medical institution, so if you are interested, please check the homepage of each medical institution or the contact information in advance.
(4) Cooling / end
If redness occurs after the injection of the application product is completed, cooling may be performed for several minutes immediately afterwards. If you wish, you can make up in the make-up room, and those who receive multiple treatments will finish by booking the next treatment day.
Rejuran injections for beauty purposes such as wrinkles, open pores, bears, and firmness are not covered by insurance, so you will be responsible for the cost of the procedure. There are differences in the free medical treatment menu because each medical institution can set the price, but the guideline for the price is as follows.
|Type of formulation||Injection volume||Estimated price|
|Rejuran||2cc||35,000 to 75,000 yen|
|Rejuran i||1cc||40,000 yen to 65,000 yen|
|Rejuran s||1cc||40,000 yen to 70,000 yen|
|Rejuran HB||1cc||40,000 yen to 70,000 yen|
If you are concerned about deep wrinkles such as nasolabial folds and gorgo lines in addition to fine wrinkles around the eyes, combine hyaluronic acid injection, which has the effect of supplementing skin volume, in addition to rejuran injection. You have the option of receiving it. Rejuran injection can improve fine wrinkles, and hyaluronic acid injection can be expected to make deep wrinkles less noticeable .
It is also possible to combine it with Dermapen 4, which aims to improve pore opening and acne scars by making a number of fine needle holes in the skin with a machine and drawing out the natural healing power of the skin. By applying Rejuran's preparation to the skin instead of injecting it after making a needle hole with Dermapen 4, the drug can penetrate evenly and a synergistic effect of skin regeneration can be expected.
Those who are allergic to fish or roe cannot receive the rejuran injection, but basically it can be injected regardless of the site, and by receiving the treatment with a formulation that suits you, wrinkles, pores, bears, etc. It can be expected to be effective for various symptoms that occur with aging, such as skin firmness and texture .
There is no immediate effect or dramatic change that you can feel the effect immediately after receiving the treatment, but you can feel the change in skin quality little by little with each treatment. In addition, depending on the worries that you want to improve, you may need to use Rejuran injection in combination with other treatments.
Therefore, when considering treatment, we propose a medical institution that handles a wide variety of rejuran preparations and a menu that offers various injection treatments and can be expected to have better effects when combined with rejuran injection. It is safe to receive the treatment under the doctor who will give you.