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Swelling after corona vaccination? Unknown complications and avoidance of hyaluronic acid injection

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Hidemasa Shinohara
Dr. Hidemasa Shinohara

Skin Refine Clinic Ginza

Regular member of the Japanese Society of Plastic Surgery Certified specialist Regular member of the Japanese Society of Clinical Dermatology Regular member of the Japanese Society of Cranial Forehead Surgery

Medical institution with Dr. Hidekatsu Shinohara

Skin refine clinic Skin Refine Clinic Ginza
Contact: 0120-661-062

Swelling after corona vaccination? Unexpectedly unknown merger and avoidance of hyaluronic acid injection

Hyaluronic acid injection is a cosmetological treatment that is in increasing demand due to the sense of security that hyaluronic acid is a component that originally exists in the human body and is an absorbent preparation, and because changes appear immediately after injection.

Risks of redness, swelling, and pain are inherent in all cosmetic treatments, not just hyaluronic acid injections, but recent coronavirus infections and vaccinations have caused swelling at the hyaluronic acid injection site that was injected weeks to months ago. Complications have been reported .

Some people may hesitate to inject hyaluronic acid when they find out that there are potential complications, but knowing it in advance can reduce anxiety and risk.

In order to receive hyaluronic acid injection with peace of mind, it is important to acquire knowledge about the effects of coronavirus infection and vaccination on hyaluronic acid injection and how to reduce the risk .

Coronavirus infection / vaccination and hyaluronic acid injection therapy

The risks of injecting hyaluronic acid include complications such as redness, internal bleeding, infection, unevenness, and allergic reactions, but recently, after coronavirus infection or vaccination, the site where hyaluronic acid was injected weeks to months ago , Cases of swelling have been reported.

In this way, the appearance of induration / nodular changes (lumps) accompanied by an inflammatory reaction or inflammatory reaction at the treatment site after several weeks to several months after injection is called "Delay Inflammatory Reaction" . increase.

Symptoms have been reported to be relieved by oral antihistamines and steroids, and they may resolve spontaneously, so basically there is nothing to worry about.

Unexpectedly unknown "allergic / rejection" of hyaluronic acid injection

Allergic / rejection reactions, including delayed inflammatory reactions, are one of the complications of hyaluronic acid injection, and differ from infectious diseases in that they occur in parts of the injection site or in areas unrelated to the injection site.

Causes of allergies / rejection

The cause of delayed inflammatory reaction, allergy, and rejection is not clearly known, but the effects of the cross-linking agent contained in the hyaluronic acid preparation, the molecular weight of hyaluronic acid, and the structure are considered.

When chemical substances or bacteria enter the body, T cells that give instructions to produce antibodies activate the function of macrophages that eat foreign substances and waste products excessively. As a result, it is thought that inflammation occurs by attacking cells and tissues.

In addition, one to two weeks before the onset, there were many cases of symptoms such as sore throat, sneezing, nasal discharge, headache, and dullness, oral treatment, and injuries. Is known to be the trigger.

It may occur after coronavirus infection or vaccination, but it is thought that it may be triggered by activation of systemic immunity due to coronavirus infection / vaccination.

Treatment method for allergies and rejection reactions

Allergic / rejection reactions, including delayed inflammatory reactions, have a low incidence, but may recur or take several months to heal .

Hyaluronic acid is absorbed and decomposed over 2 to 4 months, so spontaneous healing can be expected in the process, but depending on the symptoms, it may not be realistic to leave it as it is.

In that case, if there is a suspicion of an infectious disease, administer antibiotics systemically and then perform the following treatments.

  • Oral anti-allergic agent
  • Local injection of steroids
  • Local injection of 5-Fluorouracil (5-FU) added to steroid (triamcinolone)
  • Injection of hyaluronic acid degrading enzyme "hyaluronidase", etc.

If these treatments do not improve, consider excision surgery.

To reduce the risk of allergies / rejection due to hyaluronic acid injection

To avoid allergic / rejection problems, including delayed inflammatory reactions, it is safe to know in advance how to reduce the incidence.

Involvement of cross-linking agents in allergy / rejection

Hyaluronic acid artificially made for the purpose of beauty is a small molecule hyaluronic acid because it is a short hyaluronic acid that is not connected to each other.

The chains of small molecule hyaluronic acid that are not linked to each other are easily decomposed and absorbed by enzymes existing in the body as they are, and as a result, the duration of the effect is shortened.

Therefore, a cross-linking agent (kakyozai), which is an adhesive, is added to the hyaluronic acid preparation to bind the chains of hyaluronic acid together. In order to maintain a certain level of persistence, a cross-linking agent is added to connect the short chains of hyaluronic acid that had been separated, and by reproducing the structure of the chains, the speed of decomposition in the body is slowed down.

It has been pointed out that the cross-linking agent contained in the hyaluronic acid preparation is involved in the cause of delayed inflammatory reaction, allergy and rejection. Although the cross-linking agent is contained in almost all hyaluronic acid preparations, we believe that the risk of delayed inflammatory reaction, allergy, and rejection can be reduced by selecting a hyaluronic acid preparation with the lowest possible cross-linking agent ratio. Will be.

Effect of molecular weight of hyaluronic acid on allergic / rejection reactions

Hyaluronic acid that exists in nature is a high molecular weight hyaluronic acid that has a naturally long molecular structure with clusters, but the artificially made hyaluronic acid preparation hyaluronic acid is a low molecular weight hyaluronic acid.

According to a report investigating whether macrophage activity differs depending on the molecular weight of hyaluronic acid, it is known that low molecular weight hyaluronic acid has an inflammation-inducing effect and high molecular weight hyaluronic acid has an anti-inflammatory effect. ..

By using a hyaluronic acid preparation containing high molecular weight hyaluronic acid as the main component, it is thought that the risk of delayed inflammatory reaction and allergic / rejection reaction can be reduced .

Be careful not to add too much hyaluronic acid

The higher the injection amount of the hyaluronic acid preparation, the higher the rate of cross-linking agent entering the body. A small injection volume can reduce the risk of allergies and rejection.

In recent years, "hyaluronic acid overfill syndrome" has been pointed out, but it is important to avoid overfilling the face and make the face look unnatural, and to inject the minimum amount of hyaluronic acid to produce results.

Hyaluronic acid injection is known to have serious complications such as skin necrosis, cerebral infarction, and blindness, in addition to allergies and rejection reactions.

A common premise to prevent these complications is that hyaluronic acid preparations should be infused in small doses .

Injecting large amounts into one site increases the risk of vascular embolism and pressure on blood vessels, which can lead to serious complications.

To prevent complications including delayed inflammatory reaction, allergy and rejection, it is important to inject a small amount.

As for the appearance, it is wise to use a small amount so that you do not know where it is, and aim for a natural and youthful impression, rather than adding too much hyaluronic acid to cause an unnatural uplift.

Choose a hyaluronic acid preparation with a low incidence of allergies and rejection

It is known that the incidence of allergic / rejection reactions, including delayed inflammatory reactions, varies depending on the hyaluronic acid preparation.

Therefore, choosing a hyaluronic acid preparation with a low incidence increases the possibility of avoiding trouble.

The difference in the incidence is pointed out by the influence of the molecular weight of hyaluronic acid and the involvement of the cross-linking agent.

In conclusion, hyaluronic acid preparations, which are high molecular weight hyaluronic acid and have as few cross-linking agents as possible, tend to have a low incidence of allergic / rejection reactions .

Hyaluronic acid preparation Kaisense with low risk of allergies and rejection

KYSENSE® is a hyaluronic acid preparation that has the molecular structure of high molecular weight hyaluronic acid, which is said to be less likely to cause an inflammatory reaction, and has a small amount of cross-linking agent that can cause unevenness, allergies, and rejection reactions .

Artificially made hyaluronic acid preparations used in aesthetic medicine are basically hyaluronic acid with a low molecular structure, but Kaisense uses the patented OXIFREE manufacturing method to create the molecular structure of hyaluronic acid. Succeeded in retaining with a polymer.

During the manufacturing process of hyaluronic acid preparations, active oxygen that destroys the molecular structure of high molecular weight hyaluronic acid is generated, but the oxy-free manufacturing method thoroughly eliminates the generated active oxygen. As a result, Kaisense can maintain the molecular structure of the polymer.

Kaisense has high viscoelasticity due to its large molecular weight, and high forming power and lifting power can be expected over a long period of time even if the proportion of cross-linking agent is small .

In other words, redness and unevenness are likely to occur, and the amount of cross-linking agent, which is considered to be at risk of delayed inflammatory reaction and allergic / rejection reaction, enters the body relatively small.

Easy to shape with a small amount and hard to collapse

Kaisense is not only characterized by a low risk of allergies and rejection.

The ability to lift the skin tissue with high ridge force is also an important characteristic .

In general, hyaluronic acid preparations are less likely to collapse due to the high proportion of cross-linking agent, but Kaisense is said to have high forming power and be maintained for a long period of time despite the low proportion of cross-linking agent.

In the past, hyaluronic acid preparations, which have forming and maintaining power, were hard and sometimes felt uncomfortable to the touch, but Kaisense has forming power and lifting power while being soft.

After injection, it will be familiar with the surrounding tissues and you can expect a natural lift-up .

To receive hyaluronic acid injection with confidence

We talked about the delayed inflammatory reaction triggered by coronavirus infection and vaccination, and the allergic / rejection reaction of hyaluronic acid injection.

Hyaluronic acid preparations with as few cross-linking agents as possible and hyaluronic acid preparations using high molecular weight hyaluronic acid are said to be good methods for reducing the risk of allergies and rejection reactions.

Also, be careful not to overfill the hyaluronic acid preparation, and effectively inject a small amount to increase the possibility of avoiding trouble .

Since there are many types of hyaluronic acid preparations, it is important to know the characteristics of each and to be able to make the best choice.

At medical institutions that inject hyaluronic acid, it is important to inform patients not only of the benefits but also of the risk of complications including allergies and rejection.

It is necessary for the patient to choose a reliable medical institution that fully communicates the risks.

Introduction of supervising doctor

Dr. Hidekatsu Shinohara, the founder of Skin Refine Clinic and the director of Skin Refine Clinic Ginza. In injection of hyaluronic acid and botox, he gives guidance to doctors as an injection instructor. As a certified specialist of the Japan Society of Plastic and Reconstructive Surgery, we provide careful counseling and perform a wide range of treatments from injection treatment to laser treatment and phototherapy.

Medical institution with Dr. Hidekatsu Shinohara

Skin refine clinic Skin Refine Clinic Ginza
Contact: 0120-661-062

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